DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18596 and TRM3

DIOPT Version :9

Sequence 1:	NP_651031.1	Gene:	CG18596 / 42622	FlyBaseID:	FBgn0038953	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	NP_010171.1	Gene:	TRM3 / 851446	SGDID:	S000002270	Length:	1436	Species:	Saccharomyces cerevisiae

Alignment Length:	1466	Identity:	294/1466 - (20%)
Similarity:	512/1466 - (34%)	Gaps:	511/1466 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LYDLVS---MHKDNELALKRVLQCIHNLLQTNSKYNVRFGP------KVFHKLVSVVIADSREDS 96
            |.|::|   .|..|:...|:::|...:........|::...      .:.|.|..|.:.|..::.
Yeast   111 LNDIISENYKHLFNDNFGKKIVQPFFDSFAEEQNANIKHENLHLDILSLLHYLEVVYLFDECKNG 175

  Fly    97 ASRRQL---VANLLVC------------VQLHIR----------KFPRIEAKFVLQQLWSLSQSN 136
            .|.:.|   :..||.|            ::.||:          .|.::...|:.|.....||..
Yeast   176 ISSKCLDFIIVPLLGCNSEEIADSCSKLMRWHIKYLSKCCNTDSNFDKLIWTFIKQLYAEGSQQA 240

  Fly   137 ERQPHAAQILVHLFDDFVNNLGTECAQELLVLTR---------NLLQSDVRDDRRSAYFLMH-KL 191
            .:|.::...|:...      |..|.:.||:...:         ..|.:||.:.|:.|..::. .:
Yeast   241 WKQKNSLSFLLRFL------LAAELSPELITYIKTDAYWRHIQTELDNDVHEHRKLALSILKLTI 299

  Fly   192 QEIDEVLAALQ-----CSEV-------QWSAY--------------------------------- 211
            |::......||     |:::       .|..:
Yeast   300 QKLSSHGITLQTTFYKCNDLANIEMLGSWKKFTTLYEMIALDTSLNQIQAAKQDIIKIFDNEHLH 364

  Fly   212 ---------VGIMENLEEQQSHLV---------------LPTLS-TLLP---------------- 235
                     .|:..::|..:.:::               ||.|: ||||
Yeast   365 HSWGLILLSTGLKSSMESVRKYMMTLMFSITNMSAFSSNLPLLTKTLLPAAMSAHYFDVKGVSCP 429

  Fly   236 ---RMGLMSNNLSEDWLDWLRILCIRLLGDNNILVLRWT----LKYFLSHFSLEQISRFNLLTQF 293
               ::.|..|||.....:.:..:...:|   .:||.:.|    .:.:||         :.:|..|
Yeast   430 HGEKLSLFVNNLLSQTTEGISDILFEIL---KLLVEKGTSFDPSRIYLS---------YGILVFF 482

  Fly   294 LAATNRTQLYNPEVPDCLTKQQITDFSAQFPAEILLEALVCVPWHAVPLIHWLQAWELKQL---- 354
              ..|:.:..|.:....:.|  :.||:|:   |.:||..:             |...||.|
Yeast   483 --QNNKQKTINSDHLSLIRK--LYDFAAE---EEVLETTI-------------QTIYLKFLLYID 527

  Fly   355 PVVS-KELLFKLGARVRSLQNPVLRGEAINYVIFSLSATIDSLSLGDYLLFMESLYNTI-DRYQS 417
            |.|| .||||.|.:.::      |:|....||                    |.|:... |...|
Yeast   528 PSVSASELLFTLVSHIK------LKGGTYKYV--------------------EPLFEDYRDLAVS 566

  Fly   418 H-SQLAQKIRNCSNLEKHIASFNIRCCELVSQM--DYKH-DVFVAFLEKLRTVPKSKHGWWRLLP 478
            | ..|..|    .||..:|....|  .:|::.:  |:|. |:...||.:   |.|||..    :|
Yeast   567 HFDDLQAK----ENLTTNIGKDTI--FDLLASIIFDFKDIDITPDFLIE---VAKSKQD----IP 618

  Fly   479 IFLHRELDHPEQYLDFYRS---VYDLDTSFLE-SGVSLEQMQQHLLNRLDCQTREEKSFVLEHSV 539
            ::..:.:....|.|....|   .|:..|:.|. ...::...:...:|.|      .||.:.:.|:
Yeast   619 VYTSKAVTFLTQLLSGEPSNGYTYENATALLSYPNFTISTWKSINVNNL------FKSVMEKFSL 677

  Fly   540 D---LFVQINLPTWS-KLEVLNLNPLELL---------------------DRGTEETFATLSNIL 579
            |   .|.:|...|:. :.:.:.||..:||                     |......|..|:..|
Yeast   678 DKFKFFAEIYQKTYECRFDTIELNFNDLLSLYEMVKKSANQCSRESFKVKDSAYSSYFELLNTFL 742

  Fly   580 STH-----------DE-----QLADQNVLPAFISRLGKLKVRETQAILKYAVQNLSSEEYEKCVV 628
            .|:           ||     :|.|:|:.....:.||.|.|.:   :|.:.:     :.|..|..
Yeast   743 KTYALNRDSSEGNDDELHILLRLVDENINKDNGNYLGNLAVCK---LLYFII-----DSYIHCST 799

  Fly   629 DVLEKNTFLLGTMDCEEYIKAPTSFV-----IKRMLQGETTTGDARIERAF---------EQISD 679
            .|.:.:.|::      ::|....||:     .:|::..|.......|:..|         .|..|
Yeast   800 SVSDDDIFIV------KFIFEKFSFIWECINSERLVLKERDLHLMLIKGLFHPVILYFGSNQYID 858

  Fly   680 TGAMDRVQFIQYAKNSTGLDISFICDDLL-----------RMNNELSRKKPRYF-------ANCK 726
            |......:..|     |.:.:|:....||           :...:|.|:...|:       ...|
Yeast   859 TLTSKLEEHAQ-----TIISLSYSRRSLLPLLGSQLRVFMKFYGKLLREDVNYWWLINIIVGVFK 918

  Fly   727 EHRMKMRIGK------ALLD--LSDRWKWSDNLWEAVLCPSDQPNISFMYEYLVSKMLPSIDLLL 783
            :.:|.:.:.|      :|.|  |::.:...|.|:|.|..|.:           :...:..||.:|
Yeast   919 QPQMDVNLYKLKPVISSLFDHKLNNYYIKGDELYEKVYGPDE-----------ILARVSIIDSIL 972

  Fly   784 ---EQLKLLATLKPSQQISLVSVVHIYCLTRWESIQHEQLVEVFAVLLPLTMGANFQTRLLAQLV 845
               :|||:....|.:::.:.     :|.:.|.:..:..|.:..:.:||...:..|  .:.|::..
Yeast   973 YANDQLKIRLIEKVTEKTNA-----LYAIKRTDGAEALQRLLQWQLLLLSLLTTN--EKKLSETS 1030

  Fly   846 LHRICSECEDRSIQMPIADALKKSIKVTLSEKLTEFQ-------CEARL--LLPELGKQCPTSVS 901
            :.||....||.|  .|:....|:..   :|.|:.::.       .|..|  ||.:..|  |..|.
Yeast  1031 MIRILKSIEDES--SPLVRVYKEWF---ISSKVVDYYKTGNPKFAEDYLFSLLEDHSK--PVFVV 1088

  Fly   902 D----CILMMTNAPFDENISFISCSYDFRMKLKRALETFKRKQSVLIPELATS------------ 950
            .    |.:::.:...||.      .|.|...|.|.:.|       |:|..|::
Yeast  1089 SAEKICFMVLKDLRNDEK------KYGFTQLLDRFICT-------LVPNAASNKPLVRHFSNSLI 1140

  Fly   951 ---------------------------------------------------LAALNGNVQRKMN- 963
                                                               |..:.|.|.:|:.
Yeast  1141 ISLWPTFKAYLSDHTLRNIIENLYSNAKKTQIFGQYRAGDANIWDLKGDRKLTNMFGGVLKKVTD 1205

  Fly   964 ---------------------PVG-------------------------DIYP--------ESDF 974
                                 |:|                         |..|        |:..
Yeast  1206 HDCPYISESVFEKYLQEKDIVPIGTDERSLWLDKRDTNTESVNNANISCDTSPLQTKSGAWETVL 1270

  Fly   975 VVSNKARDD----HELIVVASLIDKLPNLGGLARTCEVLGVNTLILGLKSQAEKSDFTNLSMTAE 1035
            .:.||..:|    .|||||:||:||.|||||:.|.|:||||..|.:..........|.|:::||:
Yeast  1271 DLDNKKSNDVVTRSELIVVSSLVDKPPNLGGICRLCDVLGVGLLTVQDIKVKNHPQFKNVAVTAD 1335

  Fly  1036 KTLNILEVNPESLAGFLLEKQMEGYKIVGAEQTAHSTNF-VDFKFPKKSILLLGHEKHGIPANLI 1099
            :.:.:.||..:.:|.|:.||:.|||.::|.|||..|... .:|:|||||::|||.|..|||..|:
Yeast  1336 RWMPMEEVALDEIASFMKEKKKEGYTLIGLEQTDKSVKLDNNFQFPKKSLILLGTEAFGIPGTLL 1400

  Fly  1100 GFLDYAVEIPQYGLVRSLNVHVAGSLFIWEYCKQHL 1135
            ..||..:||.|:|::||:|:..|.::.:..|..||:
Yeast  1401 SELDLCLEIQQFGVIRSMNIQTATAVIVHSYTVQHM 1436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18596	NP_651031.1	SpoU_methylase	986..1128	CDD:278985	62/142 (44%)
TRM3	NP_010171.1	SpoU-like_TRM3-like	1286..1431	CDD:349964	62/144 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I1239
eggNOG	1	0.900	-	-		E1_COG0566
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6550
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002756
OrthoInspector	1	1.000	-	-		oto100014
orthoMCL	1	0.900	-	-		OOG6_102883
Panther	1	1.100	-	-	LDO	PTHR12029
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2317
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790