DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG18596 and AgaP_AGAP005789

DIOPT Version :9

Sequence 1:	NP_651031.1	Gene:	CG18596 / 42622	FlyBaseID:	FBgn0038953	Length:	1136	Species:	Drosophila melanogaster
Sequence 2:	XP_001237715.2	Gene:	AgaP_AGAP005789 / 4576628	VectorBaseID:	AGAP005789	Length:	1402	Species:	Anopheles gambiae

Alignment Length:	1399	Identity:	343/1399 - (24%)
Similarity:	551/1399 - (39%)	Gaps:	382/1399 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TATTTHAVVQAVETYIQN-QNLLGEIAELDDMLYDLVSMHKDN------------ELALKRV--- 58
            ||..|.||...::|:::. .:.|.||....|:|...:.:.|::            |..::|:
Mosquito   105 TANDTGAVHSELDTFVKRFDHELHEIPLYYDVLQTFLILAKEDTELMPHCCQLSGEQMVRRLTSE 169

  Fly    59 --------LQCIHNLLQTNSKYNVRFGPKVFHKLVSVVIADSREDSASRRQLVANLLVCVQLHIR 115
                    |.|:..||:.||        .::.:.:.|:.:             .||:
Mosquito   170 SKTIRMKALACLQTLLEFNS--------NLYGQWLCVLQS-------------PNLM-------- 205

  Fly   116 KFPRIEAKFVL--QQLWSLSQSNERQPHAAQILV--HLFDDFVNNLGTE---CAQELLVLTRNLL 173
                ||:|..|  |.|.:|.::..|:......|.  |::...:..:.|:   |.:|.|...::.:
Mosquito   206 ----IESKVFLLFQLLETLLRTGGREADIQHTLQQDHVWRLVIEGITTKDAVCRKETLATVQHAI 266

  Fly   174 ----QSDVRDDRRSAYF--LMHKLQEIDEVLAALQCSEVQWSAYVGIMENLEEQQSHLVLPTLST 232
                |.::  |....||  ...|..::...          |.::|.|:|.|.|.|:||:||.|.
Mosquito   267 GYAQQCEL--DFAGQYFNWSQDKSAQLTNA----------WQSFVTIVEALNESQTHLILPALE- 318

  Fly   233 LLPRMGLMSNNLSEDWLDWLRILCIRLLGDNNILVLRWTLKYFLSHFSLEQISRFNLLTQFLAAT 297
                   |...:....:.|..:|...:|...|..|:...|.|||.|.|.:. :...|..|||.|.
Mosquito   319 -------MIEKVQPLHVAWSNVLLRLILLHENGRVVNHGLNYFLQHRSFDP-TETELEKQFLEAF 375

  Fly   298 NRTQLYNPEVPDCLTKQQITDFSAQFPAE----ILLEALVCVPWHAVP------LIH---WLQAW 349
            ||..|...      .::.||..||.:...    .|::.|..:.|.:|.      :||   ...|.
Mosquito   376 NRAALLEN------VQEMITKLSAYYGKREAFAYLVQTLPEIEWKSVQYYCLVRVIHNGAGELAG 434

  Fly   350 ELKQLPVVSKEL--LFKLGARVRSLQNPVLRGEAINYVIFSL---------SATID--------- 394
            |.|:|...:..|  |........:::|..||     ||.|.|         ..|.|
Mosquito   435 ECKRLDEAATMLRSLTSCAKLCHTIKNVPLR-----YVTFVLLVKSVNHFSEPTTDPGLLLAVVA 494

  Fly   395 ---------SLSLGDY-----LLFMESLYNT-----------IDRYQSHSQLAQKI--RNC---S 429
                     |:|||.:     ..|.:.:.:|           .|.:.....||.:|  ..|   .
Mosquito   495 EMEKLTPIFSISLGQFQSEAGWTFCDHIADTALMPLLEQVTVADTFFVEQVLAGRIVEHGCIKNE 559

  Fly   430 NLEKHIASFNIRCC----ELVSQMDY---------KHDVFVAFLEKLRTVPKSKHGWWRLLPIFL 481
            .|.:.:...|...|    :|..::|:         .|....:..|..:|.....|..:.||....
Mosquito   560 QLFEVLIDANFPVCLKVFQLFPKLDHLLRQTISGIVHSTISSLKEGKKTNDPIPHKTFTLLAEMF 624

  Fly   482 H--------RELD--------HPEQYL----------------------------DFYRSVY--- 499
            |        .|||        |.|:.:                            |..|:||
Mosquito   625 HLNSAQALSTELDSELNLLRLHLEEIVSERLQCFDYAQASAKETIQLTHLIAAQGDLDRTVYPFF 689

  Fly   500 ------DLDTSF----LESGVSLEQMQQHLLN-RLDCQTRE---EKSFVLEHSVDLFVQINLPTW 550
                  :|:|||    .|...|::|:...:.. .|.|:.|.   .|.|..|           ..|
Mosquito   690 ASVSLKELETSFGRYQSEQPPSIDQLYVMIAEIYLHCRQRSPKCSKMFTSE-----------ACW 743

  Fly   551 SKLEVLNLNPLELLDRGTEETFATLSNILSTHDEQLA-----DQNVLPA---------------- 594
            |||       :.|||.|.......:.:||.|..||:.     ||.:||.
Mosquito   744 SKL-------INLLDVGNIHVLTVVIDILQTDGEQIGSDWYDDQALLPVVDRCYSEILNYRKSDH 801

  Fly   595 FISRLGKLKVRETQAILKYAVQNLSSEEYE-KCVV-----DVLEKNTFL--LGTMDCEEYIKAPT 651
            |:..:.|......|..:....:.:.|||.. .|.|     .:||:.:.:  |..:..|...:.|.
Mosquito   802 FMRLMEKFVRMLFQPYVSCRPETIESEEITIACFVTGYVGKLLEQASTIGGLANVVYESMYRLPV 866

  Fly   652 SFVI------KRMLQ----GETTTGDARIER----------AFEQ-----ISDTGAMDRV--QFI 689
            ..::      |.:||    ||....:.::|.          .|:|     ::...|..||  ..:
Mosquito   867 ELLLDWLGFDKLLLQGIIFGEVPKREQKLESDVIDACGVPLPFKQHSRHHLAQADARVRVLCVLV 931

  Fly   690 QYAKNSTGLDISFICDDLLRMNN-------ELSRKKPRYFANCKEHRMKMRIGKAL---LDLSDR 744
            .|...||...::.:.  ||::..       :|::.|.||:|:...||.|:||.:||   |.|:..
Mosquito   932 LYRIASTNHPVAVLF--LLKVERMLIERFAQLTKTKERYYADSITHRQKLRIVQALCVVLKLTGT 994

  Fly   745 WKWSDNLWEAVLCPSDQPNISFMYEYLVSKMLPSIDLLLEQLKLLATLKPSQQISLVSVVHIYCL 809
            ..:.  :..|:|..::||||::::|.:|:      |..::.|.:.:||: ::|:.:..:..::.:
Mosquito   995 QPYP--VLNAMLYETNQPNINYLFELIVA------DSTIDTLTIWSTLR-NEQVKVSGIQSVFVI 1050

  Fly   810 TRWESIQHEQLV--EVFAVLLPLTMGANFQTRLLAQLVLHRICSEC--EDRSIQMPIADALKKSI 870
            . |.....||.:  :...:|||.||..||.|||.||:.:.::....  .:|.....|.||:...:
Mosquito  1051 L-WLRCCREQALDEQYINLLLPWTMAQNFSTRLYAQITIKKLLERFAQHNRGPLRQIYDAVNSYL 1114

  Fly   871 KVTLSEKLTEFQC------------EARLLLPELGKQCPTSVSDCILMMTNAPFDENIS---FIS 920
            :....|:..| :|            ...|.|..:....| .|||       ||.::.:.   .:.
Mosquito  1115 RQGNVERNIE-RCMKDFRFGGVLDGHNLLTLANVFHNIP-KVSD-------APAEDVVGMDVLLE 1170

  Fly   921 CSYDF----RMKLKRALETFK----RKQSVLIPELATSLAALNGNVQRKMNPVGDIYPESDFVV- 976
            |....    ...|.:.|| ||    .|:..|.  ||.|... :..||||:.|:..:.|..:.::
Mosquito  1171 CVQAHGGCGEKNLGQVLE-FKTLPAEKRETLF--LAQSFGG-SDFVQRKIVPLKSLEPNPELLLG 1231

  Fly   977 ------SNKARDDHELIVVASLIDKLPNLGGLARTCEVLGVNTLILGLKSQAEKSDFTNLSMTAE 1035
                  :.|......|||||||:::.|||||||||.|:..:..|::.........:|..||||||
Mosquito  1232 LPQHLCAKKMDCTDGLIVVASLVNRAPNLGGLARTGEIFAIKQLVINSLQDIGNKEFQALSMTAE 1296

  Fly  1036 KTLNILEVNPESLAGFLLEKQMEGYKIVGAEQTAHSTNFVDFKFPKKSILLLGHEKHGIPANLIG 1100
            |.|.|.|:....:..:|.|.:.:||.:||||||..|......:|||||:|:|||||:|:||.:|.
Mosquito  1297 KWLKIGELKTHRVVEYLREMKEKGYSVVGAEQTTGSKAIHQLQFPKKSVLVLGHEKNGLPAEIIR 1361

  Fly  1101 FLDYAVEIPQYGLVRSLNVHVAGSLFIWEYCKQH 1134
            .||...||||:|:||||||||.|::|:|||.|||
Mosquito  1362 HLDLIGEIPQFGVVRSLNVHVTGAIFMWEYAKQH 1395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18596	NP_651031.1	SpoU_methylase	986..1128	CDD:278985	72/141 (51%)
AgaP_AGAP005789	XP_001237715.2	SpoU_methylase	1246..1389	CDD:278985	72/142 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	143	1.000	Domainoid score	I9514
eggNOG	1	0.900	-	-		E1_COG0566
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	247	1.000	Inparanoid score	I5621
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002756
OrthoInspector	1	1.000	-	-		otm50907
Panther	1	1.100	-	-	LDO	PTHR12029
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4127
TreeFam	1	0.960	-	-
	10	9.920