DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SKIP and Inppl1

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_075233.1	Gene:	Inppl1 / 65038	RGDID:	68396	Length:	1257	Species:	Rattus norvegicus

Alignment Length:	979	Identity:	186/979 - (18%)
Similarity:	302/979 - (30%)	Gaps:	351/979 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VCEWLRALGLAQ-------------YAESFLDNGYDDLEI-------CKQVGDPDLDAIGVEN-- 49
            |..|..:.||.:             |.....:|...|.|.       .|::.|.|...|.:::
  Rat   443 VTSWFTSKGLGKALDEVTVTIPHDIYVFGTQENSVGDREWLDLLRGGLKELTDLDYRPIAMQSLW 507

  Fly    50 ---------PAHRHKL----LKSIR-----SLREKGAASVYFMLNDPNSLSGSMEILCETPPNNE 96
                     |.|.:::    ..|::     :|..|||..|.||.|  .:..|.:.  |.....||
  Rat   508 NIKVAVLVKPEHENRISHVSTSSVKTGIANTLGNKGAVGVSFMFN--GTSFGFVN--CHLTSGNE 568

  Fly    97 LELVLREQLETDGVRLTAHPYSTPPSSCLSDKEEDEIYGFGYGV-FAPRVARGGLTQQQQLLQQQ 160
             :...|.|...|.:||.:          |.|:   ::..|...: |......|.|..:..:..|:
  Rat   569 -KTTRRNQNYLDILRLLS----------LGDR---QLSAFDISLRFTHLFWFGDLNYRLDMDIQE 619

  Fly   161 TLQ-------------TQQSIQQQQQQ--MQQQQQQLPIVPG-QQQQGPHQ----HQTLPPNV-- 203
            .|.             .|.::::::.:  ::..::::...|. :.::|...    |:..|..|
  Rat   620 ILNYISRREFEPLLRVDQLNLEREKHKVFLRFSEEEISFPPTYRYERGSRDTYAWHKQKPTGVRT 684

  Fly   204 ----------------AHL-----------------------------NFVQQNCLSPRSAYFY- 222
                            .|:                             .|:.:..||..|...|
  Rat   685 NVPSWCDRILWKSYPETHIICNSYGCTDDIVTSDHSPVFGTFEVGVTSQFISKKGLSKTSDQAYI 749

  Fly   223 EFPPTAEGRETKKRTTLARLLKGLKTVNRRDRNNQQNGAQARAANDRLRHFQMINGGAGGQQHSF 287
            ||.......:|..||..  .::...|.....:.:.:|.||:
  Rat   750 EFESIEAIVKTASRTKF--FIEFYSTCLEEYKKSFENDAQS------------------------ 788

  Fly   288 EETIHRLKVQEAMRKKEKFQREHEEILRDIR----QGLLQMSRGEGRMDDTYMYDEALRTGGGMG 348
            .:.|:.||||.:.|:....    :.||.||.    |.||...:.   ||....|.|.
  Rat   789 SDNINFLKVQWSSRQLPTL----KPILADIEYLQDQHLLLTVKS---MDGYESYGEC-------- 838

  Fly   349 IAGLGMPLGVGGNGGGGGAAHYAVSALHHQGH------------------WYDEPPYE---SDPD 392
            :..|...:        |..|...::.|.|:|.                  ...|..||   .|.|
  Rat   839 VVALKSMI--------GSTAQQFLTFLSHRGEETGNIRGSMKVRVPTERLGTRERLYEWISIDKD 895

  Fly   393 DFLMAGLNCGPAATIQGGRVRFSNNRESTGVISLRSAGDISL----PQRGPPRRGLIVPQQPPNP 453
            |   .|......:.::|.:...|.:|:.|   |..::..:|.    |::.||      ..:||.|
  Rat   896 D---TGAKSKAPSVLRGSQEHRSGSRKPT---STEASCPLSKLFEEPEKPPP------TGRPPAP 948

  Fly   454 PTIIPLTHARSHDRESGDYAGSISDLQSVTSRFSTVSIGTNNCTARYRTLSGGIGESPSL-SPSP 517
            |..:|        ||           :|:..|..                |.|..|...: :|.|
  Rat   949 PRAVP--------RE-----------ESLNPRLK----------------SEGTPEQEGVAAPPP 978

  Fly   518 SSDYEDIG--VTRG--HGCLP--PSLLAAKAKKNGLPHGKANTICQKATVHHSGEMRSSAKEIGA 576
            .:.:.:..  |..|  |..||  |:..|    :..:|....|.:.........|..|
  Rat   979 KNSFNNPAYYVLEGVPHQLLPLEPTSFA----RAPIPPTTKNKVAITVPAPQLGRHR-------- 1031

  Fly   577 FNENGRNFVATKDTSRDFSNSQDNTDRGS-----------MSDQA-FACSASSVESLPSASGSST 629
                         |.|....|..:.|.|.           :.|.| |........|:|...|.|.
  Rat  1032 -------------TPRVGEGSSSDEDSGGTLPPPDFPPPPLPDSAIFLPPNLDPLSMPVVRGRSV 1083

  Fly   630 ---------QALVRP-----GSPHSSI-----SAEDRTSMASCICKAKALVD---------SLPN 666
                     :|..||     .||.|:.     ||:||:.....:.|..:.||         .|||
  Rat  1084 GEARGPPPPKAHPRPPLPPGTSPASTFLEEVASADDRSCSVLQMAKTLSEVDYSPGPGRSALLPN 1148

  Fly   667 PYDKEALKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLA 731
            |.:   |:..:|.               ..:||...|        |..|::.|..:.||..:...
  Rat  1149 PLE---LQLPRGP---------------SDYGRPLSF--------PPPRIRESIQEDLAEEAPCP 1187

  Fly   732 NSGNGSHNGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLT 796
            ..|..| ..|...:...|..|||:.|....|.||::|||...::...||:..|:.:..|:..||.
  Rat  1188 QGGRAS-GLGEAGMGAWLRAIGLERYEEGLVHNGWDDLEFLSDITEEDLEEAGVQDPAHKRLLLD 1251

  Fly   797 AVQL 800
            .:||
  Rat  1252 TLQL 1255

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926	16/97 (16%)
		SAM	7..65	CDD:197735	16/97 (16%)
		SH3	657..710	CDD:302595	11/61 (18%)
		SAM	738..801	CDD:197735	20/63 (32%)
		SAM_superfamily	742..800	CDD:301707	17/57 (30%)
Inppl1	NP_075233.1	SH2_SHIP	17..119	CDD:198206
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..181
		INPP5c_SHIP2-INPPL1	425..728	CDD:197335	47/302 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..986		24/132 (18%)
		SH3-binding	945..950		3/4 (75%)
		NPXY motif	984..987		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1004..1115		23/135 (17%)
		SAM_Ship2	1193..1255	CDD:188890	19/62 (31%)
		SAM	1201..1257	CDD:197735	19/55 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810