Protein Alignment SKIP and SAMSN1

DIOPT Version :10

• Sequence 1: NP_001262827.1
• Gene: SKIP / 42601
• FlyBaseID: FBgn0051163
• Length: 1080
• Species: Drosophila melanogaster
• Sequence 2: NP_001382787.1
• Gene: SAMSN1 / 64092
• HGNCID: 10528
• Length: 701
• Species: Homo sapiens
• Alignment Length: 736
• Identity: 155/736 - (21%)
• Similarity: 278/736 - (37%)
• Gaps: 192/736 - (26%)

  Fly   294 LKVQEAMRKKEKFQREHEEILRDIRQGLLQMSRGEGRMDDTY-------MYDEALRTGGGMGIAG 351
            :|.:|:.:::..|.::..:.::.::..|..:|. ||.||..|       ...|.:.:.....|..
Human     8 VKARESYKRQSYFSKQGNKRVKLVKMNLFCISL-EGSMDSLYEPIPEQQANQENMSSRTDSPIPP 71

  Fly   352 LGMPLGVGGNGGGGGAAHYAVSALHH-------------------QGH------WYDEPPYESD- 390
            .|.......|      ....||.|.:                   :|.      |.:...:::|
Human    72 FGESEQTPNN------LFVGVSNLENAKPKKRKLFRRFMSENKIFEGKTVNDKIWQEHSKHKNDS 130

  Fly   391 ------------PDDFLMAGLNCGPAATIQG----------GRVRFSNNREST--------GVIS 425
                        .||||...::.....|:||          ....:..:.|:|        |...
Human   131 HIRRPCQLKDLNEDDFLSNNIHTYQGKTLQGTSYQVTSECWSPFHYQRHVETTVDELAIKSGSDP 195

  Fly   426 LRSAGDISLPQRGPPRRGLIVPQQPPNPPTIIPLTHARSHDRESGDYAGSISDLQSVTSRFSTV- 489
            :.|.|.:...|:....:...|.......||:|.|       ::..|..  ||.|:...||...|
Human   196 VESMGTLKRLQKLVWTKKARVQNLDEVKPTLINL-------QDEDDTL--ISCLKLTKSREKKVN 251

  Fly   490 SIGT---NNCTARYRTLSGGIGESPSLSPSPSSD----YEDIGVTRGH----------------- 530
            |:.|   .....|..|||..:|.|.:|:.....|    ||.......|
Human   252 SVSTRRKEEMEIRLDTLSASLGRSSTLNNCNLEDKLAWYEGEAYMWHHWKPFPENPLWTCLDFQI 316

  Fly   531 ----------GCLPPSLLAAKAKKNGLPHG------------KANTICQ--KATVHHSGEMRSSA 571
                      .|:..:.|.:......|.|.            :.|::.:  .:|..|.|:..:.:
Human   317 AQVGPWDHCSSCIRHTRLKSSCSDMDLLHSWRSSSFGNFDRFRNNSLSKPDDSTEAHEGDPTNGS 381

  Fly   572 KEIGAFNEN-------------------GRNFVATKDTSRDFSNSQD-----NTDR--GSMSDQA 610
            .|....:.|                   |:.::......:|..:.::     |:|.  |:.:::.
Human   382 GEQSKTSNNGGGLGKKMRAISWTMKKKVGKKYIKALSEEKDEEDGENAHPYRNSDPVIGTHTEKV 446

  Fly   611 FACSASSVESLPSASGSST--QALVRPGSPHSSISAEDRTSMASCIC-KAKALVDSLPNPYDKEA 672
            ...::.|::||.|...||:  .:.....|...|...:|....:...| :|:...|..|:|||.::
Human   447 SLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDS 511

  Fly   673 LKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGNGS 737
            ||.||||:||::.....|:|.|..:.:||:||||.|:|:.|:   .::.|.:.| :|.:||....
Human   512 LKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVISEE---EAAPKKIKA-NRRSNSKKSK 572

  Fly   738 HNGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQ--L 800
                  ::::.|.||.|:||||..:|||||.||..|:::.:.|..|.|.|.:.|.:||:|.:  |
Human   573 ------TLQEFLERIHLQEYTSTLLLNGYETLEDLKDIKESHLIELNIENPDDRRRLLSAAENFL 631

  Fly   801 LHDIECSDVDIPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSPLPSSQTPTQAVNST 865
            ..:|.....:.|...|.:.:..||...:.         ..|||||||              ::|.
Human   632 EEEIIQEQENEPEPLSLSSDISLNKSQLD---------DCPRDSGCY--------------ISSG 673

  Fly   866 DESNSLDDVVTKCSSEIMKRV 886
            :..|..:|:.::..|:::.::
Human   674 NSDNGKEDLESENLSDMVHKI 694

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SH3	657..710	CDD:473055	24/52 (46%)
		SAM_superfamily	742..800	CDD:472832	24/59 (41%)
SAMSN1	NP_001382787.1	SLY	348..492	CDD:463602	20/143 (14%)
		SH3	495..546	CDD:473055	22/50 (44%)
		SAM_SAMSN1	567..631	CDD:188960	26/69 (38%)