DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SKIP and SAMSN1

DIOPT Version :9

Sequence 1:	NP_001262827.1	Gene:	SKIP / 42601	FlyBaseID:	FBgn0051163	Length:	1080	Species:	Drosophila melanogaster
Sequence 2:	NP_001382787.1	Gene:	SAMSN1 / 64092	HGNCID:	10528	Length:	701	Species:	Homo sapiens

Alignment Length:	736	Identity:	155/736 - (21%)
Similarity:	278/736 - (37%)	Gaps:	192/736 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   294 LKVQEAMRKKEKFQREHEEILRDIRQGLLQMSRGEGRMDDTY-------MYDEALRTGGGMGIAG 351
            :|.:|:.:::..|.::..:.::.::..|..:|. ||.||..|       ...|.:.:.....|..
Human     8 VKARESYKRQSYFSKQGNKRVKLVKMNLFCISL-EGSMDSLYEPIPEQQANQENMSSRTDSPIPP 71

  Fly   352 LGMPLGVGGNGGGGGAAHYAVSALHH-------------------QGH------WYDEPPYESD- 390
            .|.......|      ....||.|.:                   :|.      |.:...:::|
Human    72 FGESEQTPNN------LFVGVSNLENAKPKKRKLFRRFMSENKIFEGKTVNDKIWQEHSKHKNDS 130

  Fly   391 ------------PDDFLMAGLNCGPAATIQG----------GRVRFSNNREST--------GVIS 425
                        .||||...::.....|:||          ....:..:.|:|        |...
Human   131 HIRRPCQLKDLNEDDFLSNNIHTYQGKTLQGTSYQVTSECWSPFHYQRHVETTVDELAIKSGSDP 195

  Fly   426 LRSAGDISLPQRGPPRRGLIVPQQPPNPPTIIPLTHARSHDRESGDYAGSISDLQSVTSRFSTV- 489
            :.|.|.:...|:....:...|.......||:|.|       ::..|..  ||.|:...||...|
Human   196 VESMGTLKRLQKLVWTKKARVQNLDEVKPTLINL-------QDEDDTL--ISCLKLTKSREKKVN 251

  Fly   490 SIGT---NNCTARYRTLSGGIGESPSLSPSPSSD----YEDIGVTRGH----------------- 530
            |:.|   .....|..|||..:|.|.:|:.....|    ||.......|
Human   252 SVSTRRKEEMEIRLDTLSASLGRSSTLNNCNLEDKLAWYEGEAYMWHHWKPFPENPLWTCLDFQI 316

  Fly   531 ----------GCLPPSLLAAKAKKNGLPHG------------KANTICQ--KATVHHSGEMRSSA 571
                      .|:..:.|.:......|.|.            :.|::.:  .:|..|.|:..:.:
Human   317 AQVGPWDHCSSCIRHTRLKSSCSDMDLLHSWRSSSFGNFDRFRNNSLSKPDDSTEAHEGDPTNGS 381

  Fly   572 KEIGAFNEN-------------------GRNFVATKDTSRDFSNSQD-----NTDR--GSMSDQA 610
            .|....:.|                   |:.::......:|..:.::     |:|.  |:.:::.
Human   382 GEQSKTSNNGGGLGKKMRAISWTMKKKVGKKYIKALSEEKDEEDGENAHPYRNSDPVIGTHTEKV 446

  Fly   611 FACSASSVESLPSASGSST--QALVRPGSPHSSISAEDRTSMASCIC-KAKALVDSLPNPYDKEA 672
            ...::.|::||.|...||:  .:.....|...|...:|....:...| :|:...|..|:|||.::
Human   447 SLKASDSMDSLYSGQSSSSGITSCSDGTSNRDSFRLDDDGPYSGPFCGRARVHTDFTPSPYDTDS 511

  Fly   673 LKFKKGDLIDVLSMNASGIWKGRCHGRVGHFKFINVEVLPEQRMKNSSSKTLAAGSRLANSGNGS 737
            ||.||||:||::.....|:|.|..:.:||:||||.|:|:.|:   .::.|.:.| :|.:||....
Human   512 LKIKKGDIIDIICKTPMGMWTGMLNNKVGNFKFIYVDVISEE---EAAPKKIKA-NRRSNSKKSK 572

  Fly   738 HNGGPCSVEDLLIRIGLKEYTSVFVLNGYEDLELFKELEPADLDYLGILNQEHRAKLLTAVQ--L 800
                  ::::.|.||.|:||||..:|||||.||..|:::.:.|..|.|.|.:.|.:||:|.:  |
Human   573 ------TLQEFLERIHLQEYTSTLLLNGYETLEDLKDIKESHLIELNIENPDDRRRLLSAAENFL 631

  Fly   801 LHDIECSDVDIPGSSSENDEARLNNINMKHGASPFGRRHFPRDSGCYEGSPLPSSQTPTQAVNST 865
            ..:|.....:.|...|.:.:..||...:.         ..|||||||              ::|.
Human   632 EEEIIQEQENEPEPLSLSSDISLNKSQLD---------DCPRDSGCY--------------ISSG 673

  Fly   866 DESNSLDDVVTKCSSEIMKRV 886
            :..|..:|:.::..|:::.::
Human   674 NSDNGKEDLESENLSDMVHKI 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SKIP	NP_001262827.1	SAM_Samd5	4..65	CDD:188926
		SAM	7..65	CDD:197735
		SH3	657..710	CDD:302595	24/52 (46%)
		SAM	738..801	CDD:197735	24/64 (38%)
		SAM_superfamily	742..800	CDD:301707	24/59 (41%)
SAMSN1	NP_001382787.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11453
eggNOG	1	0.900	-	-		E1_KOG4384
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40721
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12301
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5033
SonicParanoid	1	1.000	-	-		X5009
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.900