Protein Alignment CG6015 and WDR25

DIOPT Version :10

• Sequence 1: NP_651005.1
• Gene: CG6015 / 42593
• FlyBaseID: FBgn0038927
• Length: 576
• Species: Drosophila melanogaster
• Sequence 2: NP_078791.3
• Gene: WDR25 / 79446
• HGNCID: 21064
• Length: 544
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 129/556 - (23%)
• Similarity: 217/556 - (39%)
• Gaps: 129/556 - (23%)

  Fly   114 EKAHINAFEFENQRRTFHTYGYALDPSVDDQADGQSFVGDLQSAYDDNGKTVFEPPKAKKLRKQE 178
            |..|..:|....|::  .|.|.|..|       ||.|...           ..:.|||.  .:..
Human    23 ETEHAGSFNATGQQK--DTSGVARPP-------GQDFASG-----------TLDVPKAG--AQPT 65

  Fly   179 KNDNPEDIEGFLGP--------WGKFEN--------EVSVAKPNEQER----------AELDELL 217
            |:.:.||..|:..|        ||...:        |..|..|.::..          |....|.
Human    66 KHGSCEDPGGYRLPLAQLGRSDWGSCPSQRLQWPGKEPQVTFPIKEPSCSSLWTSHVPASHMPLA 130

  Fly   218 SKRHKRGRIPEDKPLEEKSTLHIKDAYDYQGRS-------------YLHAPHDL----------- 258
            :.|.|:.::..:.|   ||:.|.:...:..|::             ..:.|..|
Human   131 AARFKQVKLSRNFP---KSSFHAQSESETVGKNGSSFQKKKCEDCVVPYTPRRLRQRQALSTETG 192

  Fly   259 -GVNLRSNAPPT--------------------------KCFLPKAHIHTWSGHNKGISSIRWFP- 295
             |.::....||.                          :..:|:..:....||...:::|:|.|
Human   193 KGKDVEPQGPPAGRAPAPLYVGPGVSEFIQPYLNSHYKETTVPRKVLFHLRGHRGPVNTIQWCPV 257

  Fly   296 -KTAHLLLSGSMDCRVKLWEVYGERRCIRTFSGHRQAIKDIAWNNRGTNFLSASYDRYIKLWDAE 359
             ..:|:|||.|||...|:|.......|::|:|.|.:|::...|...|...||..:|..:.|.|.|
Human   258 LSKSHMLLSTSMDKTFKVWNAVDSGHCLQTYSLHTEAVRAARWAPCGRRILSGGFDFALHLTDLE 322

  Fly   360 TGDVV------SRFTTRKMPFCVKFHPDNSKQH-LFVAGTSDKKIICWDTRSGDIVQEYDRHLGS 417
            ||..:      .|.||      :||||   |.| :|:.|....::..||.|:|.:::.|...:..
Human   323 TGTQLFSGRSDFRITT------LKFHP---KDHNIFLCGGFSSEMKAWDIRTGKVMRSYKATIQQ 378

  Fly   418 VSTITFVDDNRRFVTTSD----DKSMR-IWEWDIPVDMKYIADPTMH---SMPAVTLAPNGKWMA 474
            ...|.|:.:...|::::|    |.:.| |..||.....| |::...|   :.|::.|.|......
Human   379 TLDILFLREGSEFLSSTDASTRDSADRTIIAWDFRTSAK-ISNQIFHERFTCPSLALHPREPVFL 442

  Fly   475 CQSLDNKIVIFSALNRFKMNRKKTFTGHMVSGYACQLDFSPDMSYLVSGDGDGKCYIWDWKTTKM 539
            .|:..|.:.:||.:..::|:|::.:.||.|.||:...:.||....||:|..||:..::.::|...
Human   443 AQTNGNYLALFSTVWPYRMSRRRRYEGHKVEGYSVGCECSPGGDLLVTGSADGRVLMYSFRTASR 507

  Fly   540 YKKWQAHDGVCISALWHPHEASKVVTAGWDGQIKYW 575
            ....|.|...|:...:||...|.:.|..|.|.:|.|
Human   508 ACTLQGHTQACVGTTYHPVLPSVLATCSWGGDMKIW 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6015	NP_651005.1	WD40	277..576	CDD:238121	90/316 (28%)
		WD40 repeat	289..327	CDD:293791	14/39 (36%)
		WD40 repeat	332..368	CDD:293791	11/41 (27%)
		WD40 repeat	374..412	CDD:293791	12/38 (32%)
		WD40 repeat	418..453	CDD:293791	10/39 (26%)
		WD40 repeat	461..500	CDD:293791	9/38 (24%)
		WD40 repeat	509..532	CDD:293791	7/22 (32%)
WDR25	NP_078791.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	17..74		17/72 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..208		3/24 (13%)
		WD40	239..543	CDD:475233	89/313 (28%)
		WD 1	244..286		15/41 (37%)
		WD40 repeat	251..290	CDD:293791	14/38 (37%)
		WD 2	290..329		12/38 (32%)
		WD40 repeat	296..330	CDD:293791	10/33 (30%)
		WD 3	330..373		15/51 (29%)
		WD40 repeat	336..373	CDD:293791	14/45 (31%)
		WD 4	375..420		11/45 (24%)
		WD40 repeat	380..422	CDD:293791	11/42 (26%)
		WD 5	424..463		9/38 (24%)
		WD40 repeat	429..468	CDD:293791	9/38 (24%)
		WD 6	469..510		13/40 (33%)
		WD40 repeat	476..512	CDD:293791	8/35 (23%)
		WD 7	513..544		10/31 (32%)
		WD40 repeat	518..543	CDD:293791	8/24 (33%)