Protein Alignment Mitofilin and immt-2

DIOPT Version :10

• Sequence 1: NP_001262819.1
• Gene: Mitofilin / 42587
• FlyBaseID: FBgn0019960
• Length: 746
• Species: Drosophila melanogaster
• Sequence 2: NP_507241.2
• Gene: immt-2 / 180122
• WormBaseID: WBGene00012315
• Length: 654
• Species: Caenorhabditis elegans
• Alignment Length: 727
• Identity: 157/727 - (21%)
• Similarity: 292/727 - (40%)
• Gaps: 177/727 - (24%)

  Fly    82 AAVGGVITYAKYDDDFRKLVEKNVPGAGSVIKVAL-QEEPPFKGI-------------------- 125
            |...||..||.||::|||.:|..:||:.:::...: :||||...:
 Worm    36 AGAAGVAGYASYDNEFRKKLEGVIPGSRTILNYTIGEEEPPAPRLKDLRPLQYSADPKVPPKPFE 100

  Fly   126 TKNVNDQIDKVKSGIETVTSTVDSVTSKVTGLFGGGSGDDKSKKSKVEPVKATPAEEKRPSKPSE 190
            .|.|..::..||..::..|                            ||.|.    ||:|..|..
 Worm   101 PKPVKKELIGVKENLKETT----------------------------EPKKI----EKKPENPYI 133

  Fly   191 VSKTEAKPVSKPAAAAAPAPAAKPKDNPLPRDVVELEKAIELSAQLAVK-----EYNVAIGVLKG 250
            .:||...|..:          .:.....|...:.:.|||.:::....::     |::|
 Worm   134 GAKTPLNPQER----------NEKLTESLKNHLTQAEKATKVATSAKLETIRAIEHHV------- 181

  Fly   251 FNDDVRKVVDKAVENGENSLWTTL------KNRASARDTAVATAERAAREAQEKIVACEIALSAA 309
                  :.:.:|:|.|::..|.::      ..|.:.:|   ..||:.||.|...:|. |..|...
 Worm   182 ------QTIREAIEAGKDGDWDSVTVAHLKAKRLAEKD---EKAEKLARNAVADLVT-EANLGGQ 236

  Fly   310 ATAQNAKKV----EAVRDKIKKLVDH-IGNVKDELYRHKDTASV-----SDKYWRNVEKARNYFI 364
            ........:    :|..:|:...:|. |.|||     |.|:..:     ||:    |.::|..|.
 Worm   237 GETTQLNPLVPISKATAEKLSNELDEMISNVK-----HVDSERIFVHDYSDR----VAESRRKFQ 292

  Fly   365 DEIESIFPGLSLADKKLNLSKEDLDLFILHAYTHVLAYQKELQRLQTDGELRLKRAIDSVRGDND 429
            .|::::.|.|:..| .:.:.|.||...:.||:..:    .:|.:...|.:|..::.|.|:.....
 Worm   293 MELKAVHPNLNYED-GMKIKKADLHTILAHAHLRI----DQLSQKLIDSKLNEEKRIQSIIAKKK 352

  Fly   430 SEAL-RAQLEYHL-------EAERRKLAVENQKKIFHIHAESDKLLRLQLKKQAEAH-ADHIKDI 485
            .:.| :.:||.:.       |.:::||..|..:....|..:.|:.|:..::.|.:.: .:|.||:
 Worm   353 EDLLEKLRLETNAKQAAVIPEFDKKKLDAELARATAEIQKKYDEKLKEVVRTQKQLYDIEHAKDV 417

  Fly   486 VAQRETDLTRSFKRELEDKLATEKANYKLQLAG-MLGKLRGMDAALA-EIEDEFQERADAERTAN 548
                             |:...::.|......| .|.:|.|::.||: .::.:.:.|
 Worm   418 -----------------DEAVLKERNLHSSAVGKALAQLAGIEKALSGHLQMDIENR-------- 457

  Fly   549 QAQALWAACQALWASV----RAATPGVHYKDRLRPLKNEINAIAKVAKG---DDLVAAVLESVPK 606
            :::.:|.|.|.|..:|    ||:   ...:.|..||.:::..:.....|   |:.|..:..::.|
 Worm   458 KSKQMWLATQNLKGTVIFGNRAS---CCMEGRRAPLGDQMKTLLSCCGGGNSDEFVKTINTAMSK 519

  Fly   607 EAQERGVYPEDALRERFLNVERVARRLALVPEEGAGLPIYFLSYLQSLFIL-----RPDNPISKD 666
            .::.||.|.|..|..||..|.|:.||:|.|.|.||...:|  |:|:|...:     :..|.....
 Worm   520 TSKVRGEYTEQDLNTRFNKVCRIGRRVAYVNEGGALAHLY--SWLKSSLTIELVPKKGANESLTP 582

  Fly   667 ELENKPFDYSKLDTYDILNRARYHVDRSDFLQALKYMNLLQGASRKIAGEWMKEARLMLETQQAA 731
            .:||         .:.:|.||...........|::.:.|..||:|::|.:::.:||...|....:
 Worm   583 AVEN---------NFTLLTRAEQLWKSGKKSDAIRVLQLTDGATRRVAADFIADARRQHEALLLS 638

  Fly   732 NTLMAHAAASGL 743
            ..|:||||.:.:
 Worm   639 RLLLAHAALTSI 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mitofilin	NP_001262819.1	Mitofilin	68..739	CDD:430783	155/721 (21%)
immt-2	NP_507241.2	Mitofilin	44..633	CDD:430783	148/700 (21%)