DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox2 and Qsox4

DIOPT Version :9

Sequence 1:	NP_650998.1	Gene:	Qsox2 / 42583	FlyBaseID:	FBgn0038919	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_732891.1	Gene:	Qsox4 / 318720	FlyBaseID:	FBgn0051413	Length:	561	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	217/573 - (37%)
Similarity:	324/573 - (56%)	Gaps:	64/573 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TLLYCLLLISPADVLGRLNARKSANEASLYSDTDNVIMLDIESLRPALNLKNS-KLVQFLNSFCG 70
            :||.|:|::|..  .|.|          |::..|||:.||..|....|:...| |||||.|.||.
  Fly    11 SLLLCVLILSAG--RGEL----------LFNADDNVVQLDFASFESGLSEPTSGKLVQFFNGFCE 63

  Fly    71 DCHRFAPVFKTLSRDLYKWRRILRIYAVDCAQERNAQLCREFNIRQTPSLRFFGPDMRKNDDVLG 135
            :...|.|.||.|||.||||.|:|:::.:||.::.|..:|..::||:||:||:|.|..:...|.||
  Fly    64 ESQNFIPAFKNLSRKLYKWHRLLKVHVLDCGKDENDMICSIYSIRKTPTLRYFPPSYKLAPDNLG 128

  Fly   136 AVIPGQDPEFISSTLAELVSQNDYGPGQPNFRPLKATD--YEIFQDQDGETPIQFVALVLQ---- 194
            ..|..::|:.|.|.||..:.:.||      |:..|..|  ..|||.   ...|::||.|.|
  Fly   129 TEITHRNPKEIQSKLALNLQKLDY------FKMFKRQDNVAHIFQT---HKDIEYVAFVFQMCLD 184

  Fly   195 --------------------------PKNSKIGRDTLLELLPFKELSVRIIEDSQIFNEFGLGPD 233
                                      |..|.|||:|||||||::::.|||.::..::|:||:.|.
  Fly   185 HFLPHLETGNSMEEKYASQGDCNEDNPIVSLIGRNTLLELLPYRKVVVRIFDNHDVYNKFGISPV 249

  Fly   234 DQKLAIVDRNGTAQYLTPSSDSSEAYASTIGDFLKNRNIQPDPPLPIAVAPNFTEFLDHQNQAIL 298
            ...:.:|::.|...:|||..|||:||.:.|..||...:::|..|||.....|.:|.|.::   |.
  Fly   250 PNLVVLVNKAGKLLFLTPEMDSSKAYVAAIKQFLIFVDLKPQKPLPKTPPANISEALRYE---IF 311

  Fly   299 TKVLTPPLQVYRADLEQAIDKLLHIELRKWVLLEGNSLNALKNIIKIFRYLNPLNKDGKLLLTDL 363
            .:....|.::||||||:|||::|:::........|..:..|:|.:|:....:||..:.:..|.:|
  Fly   312 EQHKHHPSRIYRADLERAIDQILNVKFPGTTHFAGAKIVVLRNFVKLIYNSSPLKPEAREKLANL 376

  Fly   364 DNSLSSKQSIKGADFGD-LVDSLENGRRVFKARRYVGCIGSRPLLRSFTCSMWTLFHHLTVEAAK 427
            ..||..|:.:.|..|.: |:.|:::  .||..::|||||.|||.||.|.||:|.|||:|:||:.|
  Fly   377 YYSLHVKKQLSGVGFKNLLLKSVKD--YVFDGKQYVGCIASRPSLRGFNCSLWVLFHYLSVESKK 439

  Fly   428 PPNYFEAGSILKTFHGFAKYFFGCTDCSEHFQQMAIRRNLTSVKTHDEEILWLWAAHNEVNARIA 492
                .:..|:|..|.|:.::|..|.:|.....:....|.:.:|...||:|||||.|||.||.::|
  Fly   440 ----LKPKSVLLVFLGYVRFFMNCKECDMKISEFKKLRPIANVTNDDEQILWLWEAHNYVNKQLA 500

  Fly   493 GDSTEDPKFPKIQFPSAENCPTCRSNDSEWRTDEVLKYLKQLYDINNVSFYGL 545
            ||||||||||||||||..:||.||:|.:||||:|||.|||.:|.:.|:|::|:
  Fly   501 GDSTEDPKFPKIQFPSERDCPKCRNNATEWRTEEVLHYLKGIYTLKNLSWFGM 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox2	NP_650998.1	PDI_a_QSOX	40..152	CDD:239290	49/112 (44%)
Qsox2	NP_650998.1	Evr1_Alr	413..504	CDD:282612	41/90 (46%)
Qsox4	NP_732891.1	PDI_a_QSOX	32..145	CDD:239290	49/112 (44%)
Qsox4	NP_732891.1	Evr1_Alr	425..512	CDD:282612	41/90 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469392
Domainoid	1	1.000	65	1.000	Domainoid score	I3612
eggNOG	1	0.900	-	-		E1_KOG1731
Homologene	1	1.000	-	-		H65608
Inparanoid	1	1.050	163	1.000	Inparanoid score	I1610
Isobase	1	0.950	-	0	Normalized mean entropy	S4773
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm1146
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	P	PTHR22897
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1232
	13	12.750