DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox2 and Qsox1

DIOPT Version :9

Sequence 1:	NP_650998.1	Gene:	Qsox2 / 42583	FlyBaseID:	FBgn0038919	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001020116.1	Gene:	Qsox1 / 104009	MGIID:	1330818	Length:	748	Species:	Mus musculus

Alignment Length:	568	Identity:	183/568 - (32%)
Similarity:	290/568 - (51%)	Gaps:	69/568 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TLLYCLLLISPADVL----GRLNARKSANEASLYSDTDNVIMLDIESLRP-ALNLKNSKLVQFLN 66
            :||..|||:||  :|    |...||.|.    |||.:|.:.:||.:|:|| .|...::..|:|..
Mouse    12 SLLLLLLLLSP--LLFSGPGAYAARLSV----LYSSSDPLTLLDADSVRPTVLGSSSAWAVEFFA 70

  Fly    67 SFCGDCHRFAPVFKTLSRDLYKWRRILRIYAVDCAQERNAQLCREFNIRQTPSLRFFGPDMRKND 131
            |:||.|..|||.:|.|:.|:..||..|.:..:|||:|.|:.:||||||...|::||| ....||.
Mouse    71 SWCGHCIAFAPTWKELANDVKDWRPALNLAVLDCAEETNSAVCREFNIAGFPTVRFF-QAFTKNG 134

  Fly   132 DVLGAVIP--GQDPEFISSTLAE-LVSQND-YGPGQPNFRPLKATDYEIFQDQDGETPIQFVALV 192
            .  ||.:|  |.:.:.:...|.: |.|..| :.|..|...|.|..|.:.|..::   ...::|||
Mouse   135 S--GATLPGAGANVQTLRMRLIDALESHRDTWPPACPPLEPAKLNDIDGFFTRN---KADYLALV 194

  Fly   193 LQPKNSKIGRDTLLELLPFKELSVRII--EDSQIFNEFGLGPDDQKLAIVDRNGTAQYLTPSSDS 255
            .:.::|.:||:..|:|..:..::||.:  .:|.:.|:||: .|.....::.|||:...:....:|
Mouse   195 FEREDSYLGREVTLDLSQYHAVAVRRVLNTESDLVNKFGV-TDFPSCYLLLRNGSVSRVPVLVES 258

  Fly   256 SEAYASTIGDFLK-----NRNIQPDPPLPIA---VAPNFTEFLDHQNQAILTKVLTPPLQVYRAD 312
            ...|.|    :|:     .|:..|....|:.   :||...:|.|..             ::|.||
Mouse   259 RSFYTS----YLRGLPGLTRDAPPTTATPVTADKIAPTVWKFADRS-------------KIYMAD 306

  Fly   313 LEQAIDKLLHIELRKWVLLEGNSLNALKNIIKIFRYLNPLNKDGKLLLTDLDNSLS------SKQ 371
            ||.|:..:|.:|:.|:.:|||..|.|||..:.:.....|    |:.|:.:..:|::      .|:
Mouse   307 LESALHYILRVEVGKFSVLEGQRLVALKKFVAVLAKYFP----GQPLVQNFLHSINDWLQKQQKK 367

  Fly   372 SIKGADFGDLVDSLENGRRVFKARRYVGCIGSRPLLRSFTCSMWTLFHHLTVEA-----AKPPNY 431
            .|..:.|...:||.:....:.:...:|||.||.|..|.|.||:|.|||.|||:|     |.|...
Mouse   368 RIPYSFFKAALDSRKEDAVLTEKVNWVGCQGSEPHFRGFPCSLWVLFHFLTVQANRYSEAHPQEP 432

  Fly   432 FEAGSILKTFHGFAKYFFGCTDCSEHFQQMAIRRNLTSVKTHDEEILWLWAAHNEVNARIAGDST 496
            .:...:|:....:.::||||.||::||:||| ..::..|::....|||||.:||.||||::|..:
Mouse   433 ADGQEVLQAMRSYVQFFFGCRDCADHFEQMA-AASMHQVRSPSNAILWLWTSHNRVNARLSGALS 496

  Fly   497 EDPKFPKIQFPSAENCPTCRSNDSE----WRTDEVLKYLKQLYDINNV 540
            |||.|||:|:|..|.|..|.:..:.    |.....|.:||..:...|:
Mouse   497 EDPHFPKVQWPPRELCSACHNELNGQVPLWDLGATLNFLKAHFSPANI 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox2	NP_650998.1	PDI_a_QSOX	40..152	CDD:239290	44/114 (39%)
Qsox2	NP_650998.1	Evr1_Alr	413..504	CDD:282612	41/95 (43%)
Qsox1	NP_001020116.1	PDI_a_QSOX	43..155	CDD:239290	44/114 (39%)
		Evr1_Alr	409..501	CDD:282612	39/92 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..647
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835881
Domainoid	1	1.000	111	1.000	Domainoid score	I6231
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3019
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48718
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm8738
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3816
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790