DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Qsox2 and qsox1

DIOPT Version :9

Sequence 1:	NP_650998.1	Gene:	Qsox2 / 42583	FlyBaseID:	FBgn0038919	Length:	552	Species:	Drosophila melanogaster
Sequence 2:	NP_001121836.1	Gene:	qsox1 / 100004382	ZFINID:	ZDB-GENE-030131-7019	Length:	778	Species:	Danio rerio

Alignment Length:	554	Identity:	168/554 - (30%)
Similarity:	278/554 - (50%)	Gaps:	90/554 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 EASLYSDTDNVIMLDIESLRPAL-NLKNSKLVQFLNSFCGDCHRFAPVFKTLSRDLYKWRRILRI 95
            ||.||:.:|.||:|..|::...| |...:.||:|..::||.|..|:||:|:|:||:.:|:..:.:
Zfish    40 EAGLYTASDQVIVLTPENVDSTLFNNTAALLVEFYATWCGHCIAFSPVWKSLARDIKEWKPAVDL 104

  Fly    96 YAVDCAQERNAQLCREFNIRQTPSLRFF---------GPDMRK-NDDVLGAVIPGQDPEFISSTL 150
            .|:|||.|.|.::|..|.|...||::||         |.::|. :.||.|.      .::|...|
Zfish   105 AAIDCANESNRKVCTNFGITGYPSIKFFHAYSSIGSRGLEVRGFSRDVRGL------RQYIIENL 163

  Fly   151 AELVSQNDYGPGQPNFRPLK-ATDYEIFQDQDGETPIQFVALVLQPKNSKIGRDTLLELLPFKEL 214
             ||.:: .:.|..|   ||: |::.|:........ ::::|||.:.|.|.:||:..|:||.::.:
Zfish   164 -ELHTE-AWPPACP---PLETASEAEVHHFFPANN-VKYLALVFENKKSYVGREVTLDLLQYENI 222

  Fly   215 SVRIIEDSQ--IFNEFGLGPDDQKLAIVDRNGTAQYLTPSSDSSEAYA----------------S 261
            :||.:.|::  :.:.||: .:.....:.|.:|....|....::...|:                :
Zfish   223 AVRRVLDTETNLVSRFGV-TEFPSCYLYDSSGNITRLKVLKEARTFYSYALQRLPGVVRTGKHQT 286

  Fly   262 TIGDFLKNRNIQPDPPLPIAVAPNFTEFLDHQNQAILTKVLTPPLQVYRADLEQAIDKLLHIELR 326
            .|.:.:||..:|...|.               |::          :||.:|||.|:...|.:||.
Zfish   287 PITELIKNSTLQEWRPF---------------NKS----------RVYMSDLESALHYSLRVELS 326

  Fly   327 KWVLLEGNSLNALKNIIKIFRYLNPLNKDGKLLLTDLDNSLSSKQ--SIKGADFGDLVDS-LENG 388
            ....:.|:.|.|||..|.:.....|.....|..|..:|:.|.|::  .||.:||.|::|: ::..
Zfish   327 SHTSISGDDLIALKKYINVLAKYFPGRPSVKSALQAVDSWLQSQKGTEIKYSDFRDVLDNVVQTS 391

  Fly   389 RRVF-KARRYVGCIGSRPLLRSFTCSMWTLFHHLTVEAAKPPNYFEAGS-------ILKTFHGFA 445
            ..|. :..::|||.||:...|.:.|::|||||.|||:|.      |.||       :|....|:.
Zfish   392 DAVLPEGVQWVGCQGSQARYRGYPCAVWTLFHVLTVQAK------EMGSTVSEPQEVLLAMRGYV 450

  Fly   446 KYFFGCTDCSEHFQQMAIRRNLTSVKTHDEEILWLWAAHNEVNARIAGDSTEDPKFPKIQFPSAE 510
            ..||||..|:.||:.|| ..::..|.:....::|||:.||.||.|:|||.:|||.|||||:||.|
Zfish   451 SSFFGCRPCATHFEAMA-AESMDQVNSLSGAVIWLWSRHNRVNNRLAGDLSEDPHFPKIQWPSPE 514

  Fly   511 NCPTCRS----NDSEWRTDEVLKYLKQLYDINNV 540
            .||:|..    .|..|..|||.::|:..:..:.:
Zfish   515 LCPSCHGVTIIGDHNWIKDEVPQFLQNYFSSSRI 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Qsox2	NP_650998.1	PDI_a_QSOX	40..152	CDD:239290	41/122 (34%)
Qsox2	NP_650998.1	Evr1_Alr	413..504	CDD:282612	40/97 (41%)
qsox1	NP_001121836.1	PDI_a_QSOX	48..161	CDD:239290	40/118 (34%)
qsox1	NP_001121836.1	Evr1_Alr	417..508	CDD:282612	40/97 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170579251
Domainoid	1	1.000	115	1.000	Domainoid score	I5973
eggNOG	1	0.900	-	-		E1_KOG1731
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2961
OMA	1	1.010	-	-		QHG48718
OrthoDB	1	1.010	-	-		D158783at33208
OrthoFinder	1	1.000	-	-		FOG0001506
OrthoInspector	1	1.000	-	-		mtm6583
orthoMCL	1	0.900	-	-		OOG6_102428
Panther	1	1.100	-	-	O	PTHR22897
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1232
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770