DRSC/TRiP Functional Genomics Resources

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Protein Alignment E2f1 and E2F8

DIOPT Version :10

Sequence 1:NP_001262809.1 Gene:E2f1 / 42550 FlyBaseID:FBgn0011766 Length:821 Species:Drosophila melanogaster
Sequence 2:NP_078956.2 Gene:E2F8 / 79733 HGNCID:24727 Length:867 Species:Homo sapiens


Alignment Length:586 Identity:124/586 - (21%)
Similarity:197/586 - (33%) Gaps:198/586 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   249 SGDR------NRADTSLGILTKKFVDLLQESPDGVVD----LNEASNRLHVQKRRIYDITNVLEG 303
            |||.      :|.:.|||:|..||:......|:..|:    |:|.:..|:|::||||||.||||.
Human   102 SGDEFEKSQPSRKEKSLGLLCHKFLARYPNYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLES 166

  Fly   304 INILEKKSKNNIQWRCGQSMVSQERSRHIEADSLRLEQQENELNK-AIDLMRENLAEISQEVE-- 365
            ::::.:.:||...|          ..||....:|...:...|.|| |..:|.....|..||.:  
Human   167 LHMVSRLAKNRYTW----------HGRHNLNKTLGTLKSIGEENKYAEQIMMIKKKEYEQEFDFI 221

  Fly   366 ------------NSG-----GMAYV----TQNDLLNVDLFKDQ---------IVIVIKAPPE--- 397
                        |:|     .|.:|    .:....:|:..||:         :::.:.:.|:   
Human   222 KSYSIEDHIIKSNTGPNGHPDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVS 286

  Fly   398 ----AKLV----------RSATALKFQPLPFNLN-LPNTKLPREIYVKAENSGEINVFLCHDTSP 447
                ||::          :|....|.:.|....| |.:..|.::::| .|..|....|..  |.|
Human   287 LEVAAKILIGEDHVEDLDKSKFKTKIRRLYDIANVLSSLDLIKKVHV-TEERGRKPAFKW--TGP 348

  Fly   448 ENSPIAPGAGYV-----------GAPGAGCVRTATSTRLHPLTNQRLNDPLFNNIDAMSTKGLFQ 501
            |.||...|:..|           .:....|.:...|||         ..|.|             
Human   349 EISPNTSGSSPVIHFTPSDLEVRRSSKENCAKNLFSTR---------GKPNF------------- 391

  Fly   502 TPYRSARNLSKSIE-------------------EAAKQSQPEYNNICDIAMGQHHNLNQQQQQQQ 547
            |.:.|...|.||||                   |:::.|.|..:.:..:|......|.:|..:.:
Human   392 TRHPSLIKLVKSIESDRRKINSAPSSPIKTNKAESSQNSAPFPSKMAQLAAICKMQLEEQSSESR 456

  Fly   548 QQLLQQ-----------PEEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFSSL------ 595
            |::..|           |.:..|:.|:....|:|..|:        ...|.|....||.      
Human   457 QKVKVQLARSGPCKPVAPLDPPVNAEMELTAPSLIQPL--------GMVPLIPSPLSSAVPLILP 513

  Fly   596 -TESSPP-----TPTKRRREAAAAAIAAGSSTTATTTLNSHNNRNHSNHSNHSNHSSSNNSKSQP 654
             ..|.|.     .||:..:....   ..|.|.|..||        ||:.:..|..|:.       
Human   514 QAPSGPSYAIYLQPTQAHQSVTP---PQGLSPTVCTT--------HSSKATGSKDSTD------- 560

  Fly   655 PTIGYGSSQRRSDVPMYNCAMEGATTTSATADTTAATSRSAAASSLQMQFAAVAESNNGSSSGGG 719
                                   |||..|..||:.|::.:...|.|.......|:|.....:|..
Human   561 -----------------------ATTEKAANDTSKASASTRPGSLLPAPERQGAKSRTREPAGER 602

  Fly   720 G 720
            |
Human   603 G 603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E2f1NP_001262809.1 E2F_TDP 256..318 CDD:460530 24/65 (37%)
E2F_DD 327..444 CDD:473951 31/167 (19%)
coiled coil 327..362 CDD:271137 9/35 (26%)
E2F8NP_078956.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..58
E2F_TDP 114..182 CDD:460530 25/77 (32%)
E2F_TDP 262..347 CDD:460530 15/87 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 408..432 2/23 (9%)
DUF5585 <502..838 CDD:465521 28/143 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 532..616 22/113 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 771..800
Blue background indicates that the domain is not in the aligned region.

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