Protein Alignment E2f1 and e2f3

DIOPT Version :10

• Sequence 1: NP_001262809.1
• Gene: E2f1 / 42550
• FlyBaseID: FBgn0011766
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_001074097.2
• Gene: e2f3 / 791146
• ZFINID: ZDB-GENE-070112-882
• Length: 429
• Species: Danio rerio
• Alignment Length: 579
• Identity: 142/579 - (24%)
• Similarity: 216/579 - (37%)
• Gaps: 189/579 - (32%)

  Fly    38 GGSGTTGHTMVARRLNYDLHGGTTSINNNNNIVIKNESVDLDYDHVLSSSDSNSNGGVAAHLRDH 102
            |||...|..|:...:..:.||..|::::....|..|.:     ...:::..|.:||.|.....|.
Zfish     4 GGSSVPGQVMLTGVVRAEQHGVFTAVSDRRCAVYSNAT-----RIQINTPPSTNNGCVPEASADS 63

  Fly   103 VYISLDKG--HNTGAVATAAAAATAGHTQQQLQQQHHHQNQQQRKATGKSNDITNYYKVKRRPHA 165
            :|.:..:|  |.||...|..........:..:..   ||..:..|.            ::.|..|
Zfish    64 LYTTPLQGSTHGTGLRPTLGRPPAKRRLELDITD---HQYSEPAKT------------LRSRKGA 113

  Fly   166 VSDEIHPKKQAKQSAHHQTVYQKHTASSAPQQLRHSHHQLRHDADAELDEDVVERVAKPASHHPF 230
            :..:| ||                    ||:
Zfish   114 LKLKI-PK--------------------APK---------------------------------- 123

  Fly   231 SLSTPQQQLAASVASSSSSGDRNRADTSLGILTKKFVDLLQESPDGVVDLNEASNRLHVQKRRIY 295
               ||.              ::.|.|||||.|||||..||.:|.|||:|||:|:..|:|||||:|
Zfish   124 ---TPP--------------EKTRYDTSLGFLTKKFCQLLAQSSDGVLDLNKAAIVLNVQKRRLY 171

  Fly   296 DITNVLEGINILEKKSKNNIQWRCGQSMVSQ-------ERSRHIEADSLRLEQQENELNKAIDLM 353
            ||||||||:.:::||||||||| .|.|:.|.       .:|..:..:.|.|.|:|..|::.|...
Zfish   172 DITNVLEGVRLIKKKSKNNIQW-LGSSLPSDGGLPSPAMQSHSLAREMLALTQEERRLDELIQTC 235

  Fly   354 RENLAEISQEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVRSATALKFQPLPFNLNL 418
            ..|:.::::|: :|...||||..|:..:...|||.||.||||.|.|                |.:
Zfish   236 TRNVQQMTEEI-HSQKYAYVTYQDIRRIKSLKDQTVIAIKAPSETK----------------LEV 283

  Fly   419 PNTKLPREIYVKAENSGEINVFLCHDTSPENSPIAPGAGYVGAPGAGCVRTATSTRLHPLTNQRL 483
            |:.|...:::: :.:.|.|:||||.|.....||:..|....|
Zfish   284 PDPKESLQVHL-SSSKGPIDVFLCTDGGDSGSPLQNGLDVNG----------------------- 324

  Fly   484 NDPLFNNIDAMSTKGLFQTPYRSARNLSKSIEEAAKQSQPEYNNICDIAMGQHHNLN-------- 540
            |.|.|..:.                      :|||.....:     ::.|..:.|.:
Zfish   325 NHPAFLKVS----------------------QEAASDGPAD-----NVKMNGNSNASVNGFGPVS 362

  Fly   541 -----QQQQQQQQQLLQQPEEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFSS 594
                 .........:||||||   .:....|.|.|.:.   .:......:..|.:||.|
Zfish   363 GNAPMSPLSSSLSSILQQPEE---AIPFVPLSPALLSD---EYMLGLGDEQGISDLFDS 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:460530	43/61 (70%)
		E2F_DD	327..444	CDD:473951	35/116 (30%)
		coiled coil	327..362	CDD:271137	8/34 (24%)
e2f3	NP_001074097.2	E2F_TDP	131..195	CDD:460530	44/64 (69%)
		E2F_DD	213..306	CDD:271137	32/110 (29%)
		coiled coil	213..244	CDD:271137	7/30 (23%)