Protein Alignment E2f1 and E2f7

DIOPT Version :10

• Sequence 1: NP_001262809.1
• Gene: E2f1 / 42550
• FlyBaseID: FBgn0011766
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_848724.2
• Gene: E2f7 / 52679
• MGIID: 1289147
• Length: 904
• Species: Mus musculus
• Alignment Length: 739
• Identity: 136/739 - (18%)
• Similarity: 234/739 - (31%)
• Gaps: 255/739 - (34%)

  Fly   142 QQRKATGKSNDITNYYKVKRRPHAVSDEIHPKKQAKQSAHHQTVYQKHTASSAPQQLRHSHHQLR 206
            :||..|...|.||....|.|:|     ::.|        ...|...|...|:|...:|
Mouse    56 KQRIFTPDRNPITPVKPVDRQP-----QVEP--------WTPTANLKMLISAASPDIR------- 100

  Fly   207 HDADAELDEDVVERVAKPASHHPFS-LSTPQQQLAASVASSSSSGDR-NRADTSLGILTKKFVDL 269
                   |.:..:.:.:|..:...: :::.|..:|...|.......| :|...|||:|.:||:..
Mouse   101 -------DREKKKELFRPIENKEDAFVNSLQLDVAGDGAVDEYEKQRPSRKQKSLGLLCQKFLAR 158

  Fly   270 LQESP----DGVVDLNEASNRLHVQKRRIYDITNVLEGINILEKKSKNNIQW------------- 317
            ....|    ...:.|:|.:..|.|::||||||.||||.::::.:.:||...|
Mouse   159 YPSYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRTL 223

  Fly   318 -RCGQSMVSQE----------------------------RSRHI----EAD------------SL 337
             |.|:....:|                            |..|:    |||            ||
Mouse   224 QRLGEEQKYEEQMACLQQKELDLMGYRFGERRKDGSPDPRDPHLLDFSEADYPSSSANSRKDKSL 288

  Fly   338 RLEQQENEL----NK----AIDLMRENLAEISQEVENSGGM------AYVTQNDLLNVDLFK--- 385
            |:..|:..:    :|    .:|:..:.|.|.||:..:....      .|...|.|.::.|.|
Mouse   289 RIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDTPDHSKFKTKVRRLYDIANVLTSLALIKKVH 353

  Fly   386 ----------------------DQIVIVIKAP--PEAK--------------LVRSATALKFQPL 412
                                  |:.::.:.|.  ||.|              |||..:
Mouse   354 VTEERGRKPAFKWIGPVDFSSIDEELLDVSASILPELKKEAYGQIRVCAKERLVRYGS------- 411

  Fly   413 PFNLNLPNTKLPRE--------------------------IY-VKAENSGEINVFLCHDTSPENS 450
             ||....:.|:.|:                          || .|.|::.:...|:.:...|..|
Mouse   412 -FNTVHTSEKIQRKVSSEPSSPQGERQGSAYSLEIGSLAAIYRQKVEDNSQEEAFVSNTAVPPAS 475

  Fly   451 PIAPG----AGYVGAPGAGCVRTATSTRLHPLTNQRLNDPLFNNIDAMSTKGLFQTPYRSARNLS 511
            .:.|.    :.|...|.|..|.:...|.|...:.|  |.|          .|....|..||.:.:
Mouse   476 ILDPALSMDSEYCVKPLAQPVFSVAQTDLPAFSAQ--NGP----------SGQVGVPVPSAASDT 528

  Fly   512 KSIEEAAKQSQP-----------EYNNICDIAMGQHHNLNQQQQQQQQQLLQQPEED----DVDV 561
            ::::.|....||           .|.::       ...|:.:.:.         |||    ||..
Mouse   529 ENLKPALLAGQPLVYVPSTQLFMLYGSV-------QEGLSPESRS---------EEDGGGSDVPA 577

  Fly   562 ELNQLVPTLTNPVVRTHQFQQHQ-QPSIQELFSSLTES-----SPPTPTKRRREAAAAAIAAGSS 620
            :|: :.|:....:......|:.: :|:::.......:|     .|..|:.....|....:..|||
Mouse   578 DLS-VTPSAQKRLCEERDPQEEEDEPAMKRQSQEFEDSPLSLVMPKKPSSSTDLACPVTMGNGSS 641

  Fly   621 -----------------TTATTTLNSH---NNRNHSNHSNHSNHSSSNNSKSQPPTIGYGSSQRR 665
                             .|.....|.:   ...|.:.:.:....|:.|.....|..:.|...|..
Mouse   642 PPLEDACVKGQLPAAEEVTGKAAPNCYVASECGNPARNPDTEKPSNENEITKDPSLMQYLYVQSP 706

  Fly   666 SDVPMYNCAMEGATTTSATADTTA 689
            :.:..:|..:.|..|....|.:.|
Mouse   707 AGLNGFNMVLPGTQTPHTVAPSPA 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:460530	24/79 (30%)
		E2F_DD	327..444	CDD:473951	38/242 (16%)
		coiled coil	327..362	CDD:271137	14/86 (16%)
E2f7	NP_848724.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..80		7/23 (30%)
		E2F_TDP	144..212	CDD:460530	24/67 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	252..283		5/30 (17%)
		E2F_TDP	284..368	CDD:460530	15/83 (18%)
		Atrophin-1	558..>876	CDD:460830	30/183 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	560..628		13/77 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	846..904