Protein Alignment E2f1 and E2f1

DIOPT Version :10

• Sequence 1: NP_001262809.1
• Gene: E2f1 / 42550
• FlyBaseID: FBgn0011766
• Length: 821
• Species: Drosophila melanogaster
• Sequence 2: NP_001094248.1
• Gene: E2f1 / 399489
• RGDID: 728892
• Length: 432
• Species: Rattus norvegicus
• Alignment Length: 399
• Identity: 122/399 - (30%)
• Similarity: 175/399 - (43%)
• Gaps: 97/399 - (24%)

  Fly   221 VAKPASHHPFSLSTPQQQLAASVA-----------SSSSSGDRNRADTSLGILTKKFVDLLQESP 274
            :.:|.......|.|..|.||.|..           ...|.|:::|.:|||.:.||:|::||..|.
  Rat    81 LGRPPVKRRLDLETDHQYLAGSSGPFRGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSA 145

  Fly   275 DGVVDLNEASNRLHVQKRRIYDITNVLEGINILEKKSKNNIQWRCGQSMVS-QERSRHIEADSLR 338
            |||||||.|:..|.||||||||||||||||.::.|||||:|||...::||. .:|...:..|..:
  Rat   146 DGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSRTMVGIGQRLEGLTQDLQQ 210

  Fly   339 LEQQENELNKAIDLMRENLAEISQEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVRS 403
            |::.|.:|:..:.:....|..:|:: .:...:||||..||.::....:|:|||||||||.:|...
  Rat   211 LQESEQQLDHLMHICTTQLQLLSED-SDIQRLAYVTCQDLRSIADPAEQMVIVIKAPPETQLQAV 274

  Fly   404 ATALKFQPLPFNLNLPNTKLPREIYVKAENSGEINVFLCHDTSPENSPIAPG-AGYVGAPGAGCV 467
            .:|..||                |.:|:: .|.|:||||.:.|.|.  |:|| ..|....|..
  Rat   275 DSAETFQ----------------ISLKSK-QGPIDVFLCPEESAEG--ISPGRTSYQETSGED-- 318

  Fly   468 RTATSTRLHPLTNQRLNDPLFNNIDAMSTKGLFQTPYRSARNLSKSIEEAAKQSQPEYNNICDIA 532
            |.|.|....|..:.....|..:             |.:|...|.   :||.   .|...|
  Rat   319 RNADSGTAGPPPSPPSTSPTLD-------------PSQSLLGLE---QEAV---LPRIGN----- 359

  Fly   533 MGQHHNLNQQQQQQQQQLLQQPEEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFSSLTE 597
                              |:.|.|:|           ..:|:|......:|    ::|.||.|..
  Rat   360 ------------------LRAPMEED-----------RLSPLVAADSLLEH----VKEDFSGLLP 391

  Fly   598 S-----SPP 601
            .     |||
  Rat   392 GEFISLSPP 400

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E2f1	NP_001262809.1	E2F_TDP	256..318	CDD:460530	41/61 (67%)
		E2F_DD	327..444	CDD:473951	35/116 (30%)
		coiled coil	327..362	CDD:271137	6/34 (18%)
E2f1	NP_001094248.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..85		0/3 (0%)
		Cyclin A:CDK2 binding. /evidence=ECO:0000250|UniProtKB:Q01094	65..106		7/35 (20%)
		Interaction with BIRC2/c-IAP1. /evidence=ECO:0000250|UniProtKB:Q01094	87..189		53/113 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	98..126		11/38 (29%)
		E2F_TDP	126..190	CDD:460530	40/64 (63%)
		Leucine-zipper. /evidence=ECO:0000250|UniProtKB:Q01094	151..172		16/20 (80%)
		DEF box. /evidence=ECO:0000250|UniProtKB:Q01094	156..192		20/36 (56%)
		Required for interaction with TRIM28. /evidence=ECO:0000250|UniProtKB:Q01094	190..377		49/187 (26%)
		Dimerization. /evidence=ECO:0000255	193..282		26/88 (30%)
		E2F_DD	219..299	CDD:271137	25/79 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	297..342		16/45 (36%)
		Transactivation. /evidence=ECO:0000250|UniProtKB:Q01094	363..432		11/68 (16%)
		RB1 binding. /evidence=ECO:0000250|UniProtKB:Q01094	404..421		4/16 (25%)