DRSC/TRiP Functional Genomics Resources

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Protein Alignment E2f1 and E2F1

DIOPT Version :10

Sequence 1:NP_001262809.1 Gene:E2f1 / 42550 FlyBaseID:FBgn0011766 Length:821 Species:Drosophila melanogaster
Sequence 2:NP_005216.1 Gene:E2F1 / 1869 HGNCID:3113 Length:437 Species:Homo sapiens


Alignment Length:403 Identity:113/403 - (28%)
Similarity:177/403 - (43%) Gaps:102/403 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   221 VAKPASHHPFSLSTPQQQLAASVASS-----------SSSGDRNRADTSLGILTKKFVDLLQESP 274
            :.:|.......|.|..|.||.|...:           .|.|:::|.:|||.:.||:|::||..|.
Human    83 LGRPPVKRRLDLETDHQYLAESSGPARGRGRHPGKGVKSPGEKSRYETSLNLTTKRFLELLSHSA 147

  Fly   275 DGVVDLNEASNRLHVQKRRIYDITNVLEGINILEKKSKNNIQWRCGQSMVS-QERSRHIEADSLR 338
            |||||||.|:..|.||||||||||||||||.::.|||||:|||....:.|. ..|...:..|..:
Human   148 DGVVDLNWAAEVLKVQKRRIYDITNVLEGIQLIAKKSKNHIQWLGSHTTVGVGGRLEGLTQDLRQ 212

  Fly   339 LEQQENELNKAIDLMRENLAEISQEVENSGGMAYVTQNDLLNVDLFKDQIVIVIKAPPEAKLVRS 403
            |::.|.:|:..:::....|..:|::.: |..:||||..||.::....:|:|:|||||||.:|...
Human   213 LQESEQQLDHLMNICTTQLRLLSEDTD-SQRLAYVTCQDLRSIADPAEQMVMVIKAPPETQLQAV 276

  Fly   404 ATALKFQPLPFNLNLPNTKLPREIYVKAENSGEINVFLCHDTSPENS--PIAPGAGYVGAPGAGC 466
            .::..||                |.:|:: .|.|:||||    ||.:  .|:||           
Human   277 DSSENFQ----------------ISLKSK-QGPIDVFLC----PEETVGGISPG----------- 309

  Fly   467 VRTATSTRLHPLTNQRLNDPLFNNIDAMSTKGLFQTPYRSARNLSKSIEEAAKQSQPEYNNICDI 531
                 .|....:|::..|                           ::.:.|...|.|..:....:
Human   310 -----KTPSQEVTSEEEN---------------------------RATDSATIVSPPPSSPPSSL 342

  Fly   532 AMGQHHNLNQQQQQ---QQQQLLQQPEEDDVDVELNQLVPTLTNPVVRTHQFQQHQQPSIQELFS 593
            ......:|...:|:   .:...|:.|.::|           ..:|:|......:|    ::|.||
Human   343 TTDPSQSLLSLEQEPLLSRMGSLRAPVDED-----------RLSPLVAADSLLEH----VREDFS 392

  Fly   594 SLTES-----SPP 601
            .|...     |||
Human   393 GLLPEEFISLSPP 405

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E2f1NP_001262809.1 E2F_TDP 256..318 CDD:460530 41/61 (67%)
E2F_DD 327..444 CDD:473951 34/116 (29%)
coiled coil 327..362 CDD:271137 6/34 (18%)
E2F1NP_005216.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 42..87 0/3 (0%)
Cyclin A:CDK2 binding. /evidence=ECO:0000269|PubMed:8033208 67..108 7/24 (29%)
Interaction with BIRC2/c-IAP1. /evidence=ECO:0000269|PubMed:21653699 89..191 50/101 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 101..128 5/26 (19%)
E2F_TDP 128..192 CDD:460530 42/63 (67%)
Leucine-zipper 153..174 15/20 (75%)
DEF box 158..194 25/35 (71%)
Required for interaction with TRIM28. /evidence=ECO:0000269|PubMed:17704056 192..382 53/265 (20%)
Dimerization. /evidence=ECO:0000255 195..284 27/105 (26%)
E2F_DD 202..301 CDD:271137 35/120 (29%)
coiled coil 202..236 CDD:271137 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 300..349 10/91 (11%)
Transactivation 368..437 12/53 (23%)
RB1 binding. /evidence=ECO:0000269|PubMed:12598654 409..426
Blue background indicates that the domain is not in the aligned region.

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