Protein Alignment InR and MET

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: XP_011514525.1
• Gene: MET / 4233
• HGNCID: 7029
• Length: 1409
• Species: Homo sapiens
• Alignment Length: 1689
• Identity: 354/1689 - (20%)
• Similarity: 575/1689 - (34%)
• Gaps: 626/1689 - (37%)

  Fly   250 KQQEKDRHKCFHY------KHNYSYSPGISLLLFILLANTLAIQAVVLPAHQQHLLHNDIADGLD 308
            |.:.|...:||.|      |.....:|||.:|||.|:..                     ::|..
Human     2 KSKSKSLAECFPYDKPLIMKAPAVLAPGILVLLFTLVQR---------------------SNGEC 45

  Fly   309 KTALSVSGTQSRWTRSESNPTMRLSQNVKPCKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDAS 373
            |.||:         :||.|..|:. |.........|:|::.|          |..:.:...|...
Human    46 KEALA---------KSEMNVNMKY-QLPNFTAETPIQNVILH----------EHHIFLGATNYIY 90

  Fly   374 PLNRSFPKLTEVTDYIIIYRVTG-LHSLSKIFP--------NLS--VIRGNKLFDGYALVVYSNF 427
            .||..  .|.:|.:|     .|| :......||        |||  |.:.|   ...||||.:.:
Human    91 VLNEE--DLQKVAEY-----KTGPVLEHPDCFPCQDCSSKANLSGGVWKDN---INMALVVDTYY 145

  Fly   428 D--LMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEILAENETQLVV---LTENGKEKECRLS 487
            |  |:..|     |:.||..   :.|...::.|.|     .::|...:.   :.|..:..:|.:|
Human   146 DDQLISCG-----SVNRGTC---QRHVFPHNHTAD-----IQSEVHCIFSPQIEEPSQCPDCVVS 197

  Fly   488 KCPGEI--RIEEGHDTTAIEGELNASC----QLH--NNRRLCWNSKLCQTKCPEKCRNNCIDEHT 544
            ....::  .:::......:...:|:|.    .||  :.|||
Human   198 ALGAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRL------------------------ 238

  Fly   545 CCSQDCLGGCVIDKNGNESCISCRNVSFNNIC---MDSCPKGY-YQFDSR-----CVTANECITL 600
                         |...:..:...:.|:.::.   .||.|..| :.|:|.     .....|.:..
Human   239 -------------KETKDGFMFLTDQSYIDVLPEFRDSYPIKYVHAFESNNFIYFLTVQRETLDA 290

  Fly   601 TKFETNSVYSGIPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKECSSGLIDSLERAREFHGCT 665
            ..|.|..:                        |.|          ..:|||...:|...|   |.
Human   291 QTFHTRII------------------------RFC----------SINSGLHSYMEMPLE---CI 318

  Fly   666 IITGTEPLTISIKRESGAHVMDEL------KYGLAAVHKIQSSLMVHLTYGLKSLKFFQSLTEIS 724
            :   ||...   ||.:...|.:.|      |.|.....:|.:||...:.:|:    |.||..: |
Human   319 L---TEKRK---KRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGV----FAQSKPD-S 372

  Fly   725 GDPPMDADKYAL------YVLD------NRD----LDELWGPNQ--------------------- 752
            .:|   .|:.|:      ||.|      |::    |...:|||.
Human   373 AEP---MDRSAMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDE 434

  Fly   753 -----TVFIRKGGVFFHFNPKLCVSTINQLLPMLASKPKFFEKSDVGADSNGNRGSCGTAVLNVT 812
                 |..:::..:|           :.|...:|.:....|.|.|:   :..|.|:.....:.|.
Human   435 YRTEFTTALQRVDLF-----------MGQFSEVLLTSISTFIKGDL---TIANLGTSEGRFMQVV 485

  Fly   813 LQSVGANSAMLN-------VTTKVEIGEPQKPSNATIVF------KDPRAFIGFVFYHMIDPYGN 864
            :...|.::..:|       |:.:|.:......:..|:|.      |.|...:|...:...
Human   486 VSRSGPSTPHVNFLLDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSC----- 545

  Fly   865 STKSSDDP------CDDRWKVSSPEKSGVMVLSNLIPYTNYSYYVRTMAI--SSELT-------- 913
            |...|..|      |.|:...|....||.......:| ..|..:..:..:  .:.||
Human   546 SQCLSAPPFVQCGWCHDKCVRSEECLSGTWTQQICLP-AIYKVFPNSAPLEGGTRLTICGWDFGF 609

  Fly   914 --NAESDVKNFRTNPGRPSKVTEVVATAISDSKINV----------------------------- 947
              |.:.|:|..|...|     .|.....:|:|.:|.
Human   610 RRNNKFDLKKTRVLLG-----NESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYS 669

  Fly   948 TWSYLD-------KPYGVLTRYFIKAKLINRPTRNNNRDY------CTEPLVKAMEND-LPATTP 998
            |:||:|       ..||.:....:.....|.....|:|..      ||   :|::.|. |...||
Human   670 TFSYVDPVITSISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCT---LKSVSNSILECYTP 731

  Fly   999 TKKISDPLAGDCKCVEGSKKTSSQEYDDRKVQAGMEFENALQNFIFVPNIRKSKNGSSDKSDGAE 1063
            .:.||...|...|....:::||...|.:..:               |..|..:|:..|
Human   732 AQTISTEFAVKLKIDLANRETSIFSYREDPI---------------VYEIHPTKSFIS------- 774

  Fly  1064 GAALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEE 1128
                       ||:|                 :.|  :.:::.|::
Human   775 -----------GGST-----------------ITG--VGKNLNSVS------------------- 790

  Fly  1129 DLSSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDT 1193
                            .|.....|.|..|:||      |||:....||         .:|....:
Human   791 ----------------VPRMVINVHEAGRNFT------VACQHRSNSE---------IICCTTPS 824

  Fly  1194 VFQTT-----KRKKF--ADIVMDLKVDLEHANNT-----ESPVRVRW---------TPPVDPNGE 1237
            :.|..     |.|.|  .|.::....||.:.:|.     |.||.:..         ...:||  |
Human   825 LQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPVFKPFEKPVMISMGNENVLEIKGNDIDP--E 887

  Fly  1238 IVTYEVAYKLQKPDQVEEKKC-------------IPAADFNQTAGYLIKLNEGL-YSFRVRANSI 1288
            .|..||.       :|..|.|             :|        ..|:|||..| ..::...:|
Human   888 AVKGEVL-------KVGNKSCENIHLHSEAVLCTVP--------NDLLKLNSELNIEWKQAISS- 936

  Fly  1289 AGYGDFTEVEHIKVEPPPSYAKVFFWLLGIGLAFLIVSLFGYVCYLHKRK--------------- 1338
                  |.:..:.|:|..::..:...::.|..|.|:  |.|:..:|.|||
Human   937 ------TVLGKVIVQPDQNFTGLIAGVVSISTALLL--LLGFFLWLKKRKQIKDLGSELVRYDAR 993

  Fly  1339 ---------------VPSNDLHMN------------------------------TEVNPFYAS-- 1356
                           .|:.::..|                              |:::|...|
Human   994 VHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGSCRQVQYPLTDMSPILTSGD 1058

  Fly  1357 --------MQYIPDDWEVLRENIIQ------LAP----------LGQGSFGMVYEGILKSFPPNG 1397
                    ...:..|...|...::|      :.|          :|:|.||.||.|.|  ...:|
Human  1059 SDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTL--LDNDG 1121

  Fly  1398 VDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVRLLGVC--SRGQPALVVMELMKKGDLK 1460
            ....||:|::|......|.:.||:|..:||:|...:|:.|||:|  |.|.| |||:..||.|||:
Human  1122 KKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLRSEGSP-LVVLPYMKHGDLR 1185

  Fly  1461 SYLR--AHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAIEIADGMAYLAAKKFVHRDLAAR 1523
            :::|  .|.|..:|                       :....:::|.||.|||:|||||||||||
Human  1186 NFIRNETHNPTVKD-----------------------LIGFGLQVAKGMKYLASKKFVHRDLAAR 1227

  Fly  1524 NCMVADDLTVKIGDFGMTRDIYETDYY----RKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGV 1584
            |||:.:..|||:.|||:.||:|:.:||    :.|.|  |||:||..|||:...:::.|||:||||
Human  1228 NCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAK--LPVKWMALESLQTQKFTTKSDVWSFGV 1290

  Fly  1585 VLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIA 1648
            :|||:.|..|.||..::...:..|::.|..:.:||.|||.|:::|.:|||.::..||||.::::
Human  1291 LLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCWHPKAEMRPSFSELVS 1354

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032	29/121 (24%)
		Furin-like	510..645	CDD:395614	19/149 (13%)
		Recep_L_domain	663..781	CDD:460032	31/165 (19%)
		FN3	791..>964	CDD:442628	40/239 (17%)
		FN3	1224..1302	CDD:238020	18/100 (18%)
		PTKc_InsR_like	1364..1652	CDD:173625	114/309 (37%)
MET	XP_011514525.1	Sema_MET	44..535	CDD:200539	115/635 (18%)
		PSI	538..580	CDD:214655	9/46 (20%)
		IPT_plexin_repeat1	582..675	CDD:238585	16/98 (16%)
		IPT_plexin_repeat2	676..759	CDD:238584	19/85 (22%)
		IPT_plexin_repeat3	761..856	CDD:238586	28/196 (14%)
		IPT	857..953	CDD:214657	23/119 (19%)
		PTKc_Met_Ron	1101..1362	CDD:270649	111/282 (39%)