Protein Alignment InR and tyro3

DIOPT Version :10

• Sequence 1: NP_524436.2
• Gene: InR / 42549
• FlyBaseID: FBgn0283499
• Length: 2144
• Species: Drosophila melanogaster
• Sequence 2: NP_571507.2
• Gene: tyro3 / 30709
• ZFINID: ZDB-GENE-990714-13
• Length: 868
• Species: Danio rerio
• Alignment Length: 663
• Identity: 178/663 - (26%)
• Similarity: 305/663 - (46%)
• Gaps: 138/663 - (20%)

  Fly  1143 ELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDT--VFQTTKRKKFAD 1205
            |:||.|  .|||.||.::.|:: .|.|..|:.|...       |...|:.|  ...:...|.|..
Zfish   256 EVPPFQ--HVFEGLRSYSNYSV-RVRCDNEVGSSPF-------SPWVDFHTPQAAPSAAPKNFTF 310

  Fly  1206 IVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIPAADFNQTAGY 1270
            .:.:.::.|..|...:..:|.|.              :|||||.....|.:..:.   |.:...:
Zfish   311 DLSEQQLTLSWATLEQEELRGRL--------------LAYKLQWNQGGESQDPLL---FKENVAH 358

  Fly  1271 LIKLNEGLY---SFRVRANSIAGYGDFTEVEHIKVEPPPS----------YAKVFFWLL---GIG 1319
            |  ...|.:   :|:|.|.::||.|.::  :.:.|.|..:          :..:.|.||   .:|
Zfish   359 L--SGAGRFFNATFQVAACTMAGCGPWS--QPVLVMPVSAMQAQTQRGHMWVGLLFGLLVATMVG 419

  Fly  1320 LAFLIV-------SLFGYVCYLHKRKVP--------------------SNDLHMNTEVNPFYASM 1357
            |..:::       :.||........:||                    .:.|.:|:::.   |.:
Zfish   420 LLLIVLIRNRGKETQFGSAFAAQGAEVPVSFTAARSFNRQFPELPESTLDSLGINSDLK---AKL 481

  Fly  1358 QYIPDDWEVLRENIIQLA-PLGQGSFGMVYEGILKSFPPNGVDRECAIKTVN---ENATDRERTN 1418
            |.:     ::.|.::.|. .||:|.||.|.|..|||  .|...::.|:|.:.   .:::|.|:.
Zfish   482 QDV-----LISERLLTLGRMLGKGEFGSVREAFLKS--ENNSGQKVAVKVLKTDINSSSDIEQC- 538

  Fly  1419 FLSEASVMKEFDTYHVVRLLGVC--SRGQPAL----VVMELMKKGDLKSYLRAHRPEERDEAMMT 1477
             |.||:.||:|...:|::|:||.  .|.|..|    |::..||.|||.::|
Zfish   539 -LKEAAYMKDFHHPNVIQLIGVSLHRRAQQRLPVPMVILPFMKHGDLHTFL-------------- 588

  Fly  1478 YLNRIGVTGNVQPPTYGR--IYQMAIEIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGM 1540
            .::|:|    .:|.|..:  :.|..::||.||.||:.|..:||||||||||:.::::|.:.|||:
Zfish   589 LMSRLG----DEPFTVSQQILIQFMLDIARGMEYLSNKNIIHRDLAARNCMLNENMSVCVADFGL 649

  Fly  1541 TRDIYETDYYRKGTKGLLPVRWMPPESLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQV 1605
            ::.||..||||:|:...|||:|:..|||.|.||::.|||::|||.:||:.|....||.|:.|.::
Zfish   650 SKKIYSGDYYRQGSVSKLPVKWIALESLADNVYTTQSDVWAFGVTMWEIMTRGQTPYPGVENSEI 714

  Fly  1606 LRYVIDGGVMERPENCPDFLHKLMQRCWHHRSSARPSFLDIIAYLE---PQCPNSQFKEVSFYHS 1667
            ..|:|.|..:::|.:||..::::|..||......||||..:|..||   .:...:..||...|
Zfish   715 YEYLIKGERLKQPPDCPADIYEIMHSCWSPVPKCRPSFQHLIDQLELLWAKLNPAPVKEPLLY-- 777

  Fly  1668 EAGLQHREKERKE---RNQLDAFAAVP-----LDQDLQDREQQEDATTPLRMGDYQQNSSLDQPP 1724
             ..|:..:.|:..   |:..:....||     :::|.:|.............|||:.   :..|
Zfish   778 -VNLEEEDGEQANSGTRSSEEPSWGVPWQCAGIEEDEKDWLMVSSGAALAIGGDYRY---IIGP- 837

  Fly  1725 ESPIAMVDDQGSH 1737
              .::.:|::..|
Zfish   838 --SVSAIDEESRH 848

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
InR	NP_524436.2	Recep_L_domain	356..465	CDD:460032
		Furin-like	510..645	CDD:395614
		Recep_L_domain	663..781	CDD:460032
		FN3	791..>964	CDD:442628
		FN3	1224..1302	CDD:238020	17/80 (21%)
		PTKc_InsR_like	1364..1652	CDD:173625	109/302 (36%)
tyro3	NP_571507.2	Ig	31..113	CDD:472250
		Ig strand B	38..42	CDD:409353
		Ig strand C	51..55	CDD:409353
		Ig strand E	78..82	CDD:409353
		Ig strand F	92..97	CDD:409353
		Ig strand G	106..109	CDD:409353
		IgI_2_Axl_Tyro3_like	118..198	CDD:409407
		Ig strand A	118..121	CDD:409407
		Ig strand A'	124..128	CDD:409407
		Ig strand B	132..141	CDD:409407
		Ig strand C	146..153	CDD:409407
		Ig strand C'	155..158	CDD:409407
		Ig strand E	163..173	CDD:409407
		Ig strand F	176..185	CDD:409407
		Ig strand G	189..198	CDD:409407
		FN3	203..296	CDD:238020	16/49 (33%)
		FN3	304..387	CDD:238020	21/103 (20%)
		Protein Kinases, catalytic domain	481..764	CDD:473864	110/309 (36%)