DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ETHR and PK2-R2

DIOPT Version :9

Sequence 1:	NP_001287439.1	Gene:	ETHR / 42523	FlyBaseID:	FBgn0038874	Length:	471	Species:	Drosophila melanogaster
Sequence 2:	NP_731788.1	Gene:	PK2-R2 / 41638	FlyBaseID:	FBgn0038139	Length:	599	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	136/509 - (26%)
Similarity:	219/509 - (43%)	Gaps:	93/509 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PQIPSYIRTTAMFFCIVIMLLGVVGNVMVPIVIVKTKDMRNSTNIFLTNLSIADLLVLLVCTPTV 67
            |..|..:..|......:|.:.||:||::..|||.:...|..:||.:|.||:|:|:::|....|..
  Fly    59 PMTPLSLLATLSVGYALIFIAGVLGNLITCIVISRNNFMHTATNFYLFNLAISDMILLCSGMPQD 123

  Fly    68 LVEVNTRPETWVLGHEMCKAVPFVELTVAHASVLTILAISFERYYAICEPLKAGYVCTKGRAILI 132
            |..: ..|:.:.....:|.....:..|.|:|:||||.|.:.|||.|||.|.:...:....||:..
  Fly   124 LYNL-WHPDNYPFSDSICILESVLSETAANATVLTITAFTVERYIAICHPFRQHTMSKLSRAVKF 187

  Fly   133 CVLAWGIAALFTSPILWVAEYKLAEYIDGSSVAVCLTQAISDWTLAFFLMTISVFFVVPFVTLVV 197
            ....|..|.|...|  ...::.:.....|:|   |..:  :|:....|.::..:||..|...:.|
  Fly   188 IFAIWIAALLLALP--QAIQFSVVMQGMGTS---CTMK--NDFFAHVFAVSGFLFFGGPMTAICV 245

  Fly   198 LYGIIARNLVSNRAAMLRARPTK---PELSLKARKQVVLMLGAVVLSFFVCLLPFRVLTLWIILS 259
            ||.:|...|  .|:.:|:|.|.:   ....:.|:.:|:.||.||.::||:|..||....|..:..
  Fly   246 LYVLIGVKL--KRSRLLQALPRRCYDVNRGISAQTRVIRMLVAVAVAFFICWAPFHAQRLMAVYG 308

  Fly   260 TDQTLHDLGLVRYYSLL-YFCRIMLYLNSAMNPILYNLMSTKFRRGFKRLCQDAGRLLLELVTLG 323
            :...:........:|:| |...::.:|::.:||:|||:||.|||..||             |||.
  Fly   309 STSGIESQWFNDVFSILDYTSGVLYFLSTCINPLLYNIMSHKFREAFK-------------VTLA 360

  Fly   324 RR----KEDSSRG---------RRGTLSLGMGTNTNTNTNSSNATGATSSSILSRSSNRRCSEDI 375
            |.    .::..||         |..|.||.:.|..:..|..::.  ||:::.|:.|:|
  Fly   361 RHFGLGGKNQGRGLPHTYSALRRNQTGSLRLHTTDSVRTTMTSM--ATTTTGLNGSAN------- 416

  Fly   376 SRTRLKIEMQMPCGSDLEAMAMLQHSTLGKGI-ARRVS-DSRLMPLRNH-------QPRRH-KPQ 430
                         ||.       ..:|.|:.: ..||| ||..|..:|.       .|||. :.|
  Fly   417 -------------GSG-------NGTTTGQSVRLNRVSLDSVQMQGQNRSRQDLFDNPRRMLQTQ 461

  Fly   431 I----------SFDEESLEENKRSEAKIPTKCR-EKLP---GIAREIVNLTENT 470
            |          |..||.|:.......:.||.|. ::|.   .|:|..:.||..|
  Fly   462 ISQLSSVGDAHSLLEEDLQFPGEPLQRQPTMCSIDELTDDLAISRSRLKLTRIT 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ETHR	NP_001287439.1	7tm_4	18..>143	CDD:304433	40/124 (32%)
		7tm_1	27..294	CDD:278431	74/270 (27%)
		7tm_4	<102..307	CDD:304433	60/208 (29%)
PK2-R2	NP_731788.1	7tm_1	83..344	CDD:278431	74/270 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445873
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24243
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5416
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.970