Protein Alignment HHEX and HOXD12

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_067016.3
• Gene: HOXD12 / 3238
• HGNCID: 5135
• Length: 270
• Species: Homo sapiens
• Alignment Length: 282
• Identity: 64/282 - (22%)
• Similarity: 105/282 - (37%)
• Gaps: 68/282 - (24%)

  Fly    26 RSQSRRG------SSQSPVAVTAGIATPHA---LAMPKASLATGSSSAAPTPS------PSSATN 75
            ||..|.|      :.|||.:.......|:.   .|:|..|...|:...|.||:      |:.||.
Human     4 RSLYRAGYVGSLLNLQSPDSFYFSNLRPNGGQLAALPPISYPRGALPWAATPASCAPAQPAGATA 68

  Fly    76 IYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLFMPHF--QAA 138
            ....|:...|....:.       |.|.:.:..|  .:.|..:..:.....:......|.|  :::
Human    69 FGGFSQPYLAGSGPLG-------LQPPTAKDGP--EEQAKFYAPEAAAGPEERGRTRPSFAPESS 124

  Fly   139 AVAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMS--------NFGVKRK 195
            ...|.||::...|         |..|.......:..|...| |.|..:..        |..|:..
Human   125 LAPAVAALKAAKY---------DYAGVGRATPGSTTLLQGA-PCAPGFKDDTKGPLNLNMTVQAA 179

  Fly   196 G-------------------GQIR-----FTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDR 236
            |                   |:.|     :|.||...||..|..:::::.::|:.|:.:|.|:|:
Human   180 GVASCLRPSLPDGLPWGAAPGRARKKRKPYTKQQIAELENEFLVNEFINRQKRKELSNRLNLSDQ 244

  Fly   237 QVKTWFQNRRAKWRRANLSKRS 258
            |||.||||||.|.:|..|.:::
Human   245 QVKIWFQNRRMKKKRVVLREQA 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	22/55 (40%)
HOXD12	NP_067016.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	102..122		2/19 (11%)
		Homeodomain	203..259	CDD:459649	22/55 (40%)