Protein Alignment HHEX and HLX

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_068777.1
• Gene: HLX / 3142
• HGNCID: 4978
• Length: 488
• Species: Homo sapiens
• Alignment Length: 330
• Identity: 87/330 - (26%)
• Similarity: 128/330 - (38%)
• Gaps: 60/330 - (18%)

  Fly    10 AAFSIENILEQKSSSHRSQS------RRGSSQSPVAVTAGIATPHALAMPKASLATGSSSAAPTP 68
            ||:...:..:|:......|.      |.|:.|.|.:.|..:..||           .|.||   |
Human   117 AAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGTRVVPNPH-----------HSGSA---P 167

  Fly    69 SPSSATNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLFM- 132
            :|||....:.:.| ..:|::..|..:.:.:...|||...   ..||.:   .:..||.:...|.
Human   168 APSSKDLKFGIDR-ILSAEFDPKVKEGNTLRDLTSLLTG---GRPAGV---HLSGLQPSAGQFFA 225

  Fly   133 ---PHFQAAAVAAAAAVQP-TAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSNFGVK 193
               |..:|:|:.:.....| .:...|:.      :.||.|   .|.|..:..|      ..:..|
Human   226 SLDPINEASAILSPLNSNPRNSVQHQFQ------DTFPGP---YAVLTKDTMP------QTYKRK 275

  Fly   194 RKGGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWR-----RAN 253
            |...:..|::.|.|.||.||...||::..:|:.||..|.|||.|||.||||||.|||     :|.
Human   276 RSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQ 340

  Fly   254 LSKRSASAQGPIAG--AAVGSPSSASSSSVPVLNLGSGSRCGQQSDEEDRMYLSEDDEDDDEDEG 316
            ..|...:.:.|..|  ||.|.....|.|.      ..|....:.||.|.......|.|..:..|.
Human   341 KDKDKEAGEKPSGGAPAADGEQDERSPSR------SEGEAESESSDSESLDMAPSDTERTEGSER 399

  Fly   317 EADET 321
            ...:|
Human   400 SLHQT 404

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	28/55 (51%)
HLX	NP_068777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..173		17/68 (25%)
		Homeodomain	273..333	CDD:459649	29/59 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..488		19/80 (24%)