Protein Alignment HHEX and Hhex

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_032271.1
• Gene: Hhex / 15242
• MGIID: 96086
• Length: 271
• Species: Mus musculus
• Alignment Length: 305
• Identity: 97/305 - (31%)
• Similarity: 125/305 - (40%)
• Gaps: 78/305 - (25%)

  Fly    47 PHALAMPKASLATGSSSAAPTP--SPSSATNIY--DLSREAAAAQYAMKSMDSSAVLAPTSLRFN 107
            ||  ..|.|:.|.|....||||  .|:..|..|  |:.....|              |||.   .
Mouse     4 PH--PGPAAAPAVGVPLYAPTPLLQPAHPTPFYIDDILGRGPA--------------APTP---T 49

  Fly   108 PIYPDPASLFYQQVLQLQK---NPSLFMP---HFQAAAVAAAAAVQPTAYCDQYSPFTMDCEGFP 166
            |..|.|.|.|...|...:.   .|:...|   |..|||:|||           |.|     .||.
Mouse    50 PTLPSPNSSFTSLVSSYRTPVYEPTPVHPAFSHHPAAALAAA-----------YGP-----SGFG 98

  Fly   167 NPASAAAALY-----CNAYPAASFYMSNFGV-------------KRKGGQIRFTSQQTKNLEARF 213
            .|      ||     .|.|..|.......|.             ||||||:||::.||..||.:|
Mouse    99 GP------LYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTVELEKKF 157

  Fly   214 ASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQGPIAGAAVGSPSSASS 278
            .:.|||||.||:.||..|:|::||||||||||||||||.......::.:..:...   ..|....
Mouse   158 ETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKDALDSL---DTSCEQG 219

  Fly   279 SSVP-VLNLGSG---SRCGQQ--SDEEDRMYLSEDDEDDDEDEGE 317
            ..:| ..|.|:.   |:|...  |.|:....:|||.:.:.:.||:
Mouse   220 QDLPSEQNKGASLDRSQCSPSPASQEDPDSEISEDSDQEVDIEGD 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	32/50 (64%)
Hhex	NP_032271.1	Interaction with SOX13. /evidence=ECO:0000250|UniProtKB:Q03014	1..138		44/174 (25%)
		Required for WNT signaling induction. /evidence=ECO:0000250|UniProtKB:Q03014	138..271		52/130 (40%)
		Homeodomain	143..195	CDD:459649	32/51 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	195..271		14/73 (19%)