Protein Alignment HHEX and Nkx2-5

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_446103.2
• Gene: Nkx2-5 / 114109
• RGDID: 620520
• Length: 319
• Species: Rattus norvegicus
• Alignment Length: 292
• Identity: 75/292 - (25%)
• Similarity: 109/292 - (37%)
• Gaps: 88/292 - (30%)

  Fly    12 FSIENI--LEQKSSSHRS---QSRRGSSQSPVAVTAGIATPHALAMPKAS---LATGSSSAAPTP 68
            ||:::|  |||:..|..:   .:|..::.:|.:.......|.|.:.|:|:   ||...:...|.|
  Rat    12 FSVKDILNLEQQQRSLAAGDLSARLEATLAPASCMLAAFKPEAYSGPEAAAPGLAELRAELGPAP 76

  Fly    69 SPSSATNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNP-IY--PDPASLFYQQVLQLQKNPSL 130
            ||...:..:                       ||:..|.| .|  ||||           |:|
  Rat    77 SPPKCSPAF-----------------------PTAPTFYPRAYGDPDPA-----------KDP-- 105

  Fly   131 FMPHFQAAAVAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSNFGVKRK 195
                  .|......|:|.....|:     .:.:|...|.:.                     :|:
  Rat   106 ------RADKKELCALQKAVELDK-----AETDGAERPRAR---------------------RRR 138

  Fly   196 GGQIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSAS 260
            ..::.|:..|...||.||...:|||..||..||..||||..|||.||||||.|.:|.. ..::..
  Rat   139 KPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQR-QDQTLE 202

  Fly   261 AQGPIAGAAVGSPSSASSSSVPVLNLGSGSRC 292
            ..||       .|..|...:|||| :..|..|
  Rat   203 LLGP-------PPPPARRIAVPVL-VRDGKPC 226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	27/50 (54%)
Nkx2-5	NP_446103.2	Homeodomain	144..194	CDD:459649	27/49 (55%)