Protein Alignment HHEX and nkx2-5

DIOPT Version :10

• Sequence 1: NP_650938.2
• Gene: HHEX / 42495
• FlyBaseID: FBgn0038852
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_001116891.1
• Gene: nkx2-5 / 100144646
• XenbaseID: XB-GENE-487966
• Length: 300
• Species: Xenopus tropicalis
• Alignment Length: 295
• Identity: 77/295 - (26%)
• Similarity: 113/295 - (38%)
• Gaps: 82/295 - (27%)

  Fly     4 ATKSSKAAFSIENILEQKSSSHRSQSRRGSSQSPVAVTAGIATPHALAMPKASLATGSSSAAP-T 67
            |:..:...||:::||..:  .|:      |..||:.:|:.:.....:      |:|......| |
 Frog     3 ASPVTSTPFSVKDILNLE--QHQ------SGLSPMDITSRLENSSCM------LSTFKQEPYPGT 53

  Fly    68 PSPSSATNIYDLSREAAAAQYAMKSMDSSAVLAPTSLRFNPIYPDPASLFYQQVLQLQKNPSLFM 132
            |..|      :|:.|.|       ..|||.  .|:        |.|.|.|.:..|::..:..
 Frog    54 PCLS------ELTEELA-------QRDSSK--GPS--------PFPGSFFVKNYLEMDSSKD--- 92

  Fly   133 PHFQAAAVAAAAAVQPTAYCDQYSPFTMDCEGFPNPASAAAALYCNAYPAASFYMSNFGVKRKGG 197
            |......:   ..:|.|...|:     .:.|....|...                     ||:..
 Frog    93 PKDDKKDI---CPLQKTLEHDK-----REAEDPERPRQR---------------------KRRKP 128

  Fly   198 QIRFTSQQTKNLEARFASSKYLSPEERRHLALQLKLTDRQVKTWFQNRRAKWRRANLSKRSASAQ 262
            ::.|:..|...||.||...||||..||.|||..||||..|||.||||||.|.:|   .::..:.:
 Frog   129 RVLFSQAQVYELERRFKQQKYLSAPERDHLANVLKLTSTQVKIWFQNRRYKCKR---QRQDQTLE 190

  Fly   263 GPIAGAAVGSPSSASSSSVPVLNLGSGSRC-GQQS 296
                  .||.| .....:|||| :..|..| |:.|
 Frog   191 ------MVGLP-PPRRIAVPVL-VRDGKPCLGESS 217

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HHEX	NP_650938.2	Homeodomain	200..251	CDD:459649	29/50 (58%)
nkx2-5	NP_001116891.1	Homeodomain	132..182	CDD:459649	29/49 (59%)
		COG5576	<133..235	CDD:227863	40/96 (42%)