Protein Alignment Calx and slc8a2b

DIOPT Version :10

• Sequence 1: NP_001247215.1
• Gene: Calx / 42481
• FlyBaseID: FBgn0013995
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_009290185.1
• Gene: slc8a2b / 567212
• ZFINID: ZDB-GENE-050419-209
• Length: 967
• Species: Danio rerio
• Alignment Length: 933
• Identity: 444/933 - (47%)
• Similarity: 598/933 - (64%)
• Gaps: 98/933 - (10%)

  Fly    99 ECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163
            ||..|::||:|.|. |..:.:::||..:|||.|:|:|:|||||||||||:||.|||.|:.|.:..
Zfish    64 ECKPGILLPVWKPV-NPGLVEQIVRAIIYFVSLMYMFLGVSIIADRFMASIEVITSQEKEVTITM 127

  Fly   164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMI 228
            ||....|..||||||||:||||||||||||||||||||:....|:||:|||||||||||:|:|:|
Zfish   128 PNGETSVATVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHGFKSGELGPGTIVGSAAFNMFVI 192

  Fly   229 IAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVL 293
            |.:|:..||.||||:|:||||||:||.:|:|||:||:|||||.:||::.||||:|||.:||:.|:
Zfish   193 IGICVWVIPEGEVRKIKHLRVFFITAFWSIFAYIWLYLILSVISPGIVEVWEALVTLCYFPVCVI 257

  Fly   294 WAYIAERRLLVYKYMDKNYRVNKRGTVVAGEHDQVEMDAEKGPK--------------------- 337
            .|:||:||||.||||.|.||.:||..||      ||.:.|..||
Zfish   258 LAWIADRRLLFYKYMSKRYRADKRTGVV------VETEGEMTPKGMEMMMDGKFPLRAGDIGIGT 316

  Fly   338 ------------QPMVTSARGNDAEAF-------DEARREYITLLTELRQKYPDADLEQLEMMAQ 383
                        ..|.|....|....:       ||:|:|.|.:|.:|:|||||.:|:||..:|.
Zfish   317 QEHYQDGTGHTTGTMATLPNSNSTTVYMDGVKDLDESRKEVIRILKDLKQKYPDKELDQLVELAN 381

  Fly   384 EQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVKAQLHAGDD--EEADDPI--RM 444
            ...|....|||||||:||||.|:|:||:::|     |:.....:|.:..||:  ||.|..:  |:
Zfish   382 YYALLHQQKSRAFYRVQATRMMIGAGNVLKK-----HAADQSRRAVVVGGDEALEEEDLAVCSRI 441

  Fly   445 YFEPGHYTVMENCGEFEVRVVRRGDI--STYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQ 507
            .||..|...|||||...:.||.||.:  ||: .|:|.|:||||:||:|:...:|.|.|.||...:
Zfish   442 SFESPHSQCMENCGSIMIPVVCRGGLGESTF-YVDYCTEDGTANAGSDYEYCEGTLVFKPGETRK 505

  Fly   508 RFRIEVIDDDVFEEDECFYIRLFN----PSEGV------------KLAVPMIATVMILDDDHAGI 556
            ..::.:||||:|||||.|::||.|    .:||:            :|..|::|||.|||||||||
Zfish   506 DIKVGIIDDDIFEEDEHFFVRLLNLRIGDAEGMFESDDMDQGPKARLVEPLMATVTILDDDHAGI 570

  Fly   557 FAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTAT-ESKDYEGARGELVFENNESEK 620
            |.|||.:..::|.||..|:.|:|.||||||||:||.||..||. ...|||...|||.|.|:::.:
Zfish   571 FTFTDRMMRVSECVGTMEVTVVRNSGARGTVIIPYHTEPGTAQGGGVDYEDTHGELEFTNDQTTQ 635

  Fly   621 FIDLFILEESSYEKDVSFKVHIGEPRLAPDDTNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEK 685
            .:.:.|:::..|||..:|.:.:.|||          :..|.......:.|....:|:|:.:|..
Zfish   636 TLQVRIIDDEEYEKHENFFIVLEEPR----------WLKRGISALLLNQEDAEGQLSAEEEEAR- 689

  Fly   686 KPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDA 750
                      ||..:.||..||.:...|.|.||.|||:|||||:.|.|::.|:||.||:|||.:|
Zfish   690 ----------RIAEMGKPVLGEHSRLEVVIEESYEFKSTVDKLIKKTNLALVIGTHSWREQFVEA 744

  Fly   751 LTVIPADESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVIT 815
            :||...|..|.|.:..||..|||..||.||:.:||||||||||||:...|:..|||||.|||::|
Zfish   745 VTVSAGDGDEDDEEGREEHPPSCSDYVMHFLTVFWKVLFAFVPPTEYWNGWACFVVSITVIGLLT 809

  Fly   816 AIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFL 880
            |:|||.||:|||.:.::|:|||::||||||||||||||.:|||.|:.||..||||||||||||||
Zfish   810 AVIGDLASHFGCTVGLRDTVTAVVFVALGTSIPDTFASKVAAKQDQYADASIGNVTGSNAVNVFL 874

  Fly   881 GIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSK 945
            |||:||::||||.:..|..|||:||::.|:|.||...|.|.:.:::||| ...||.|||||:||:
Zfish   875 GIGVAWSVAAVYWAVQGKRFNVDPGSLAFSVTLFTIFAFICMAVLLFRR-RPSIGGELGGPRVSR 938

  Fly   946 YISAAILVFLWVFYVVICILEAY 968
            .::..:.:.||..|::...||||
Zfish   939 LLTTLLFLGLWFLYILFSSLEAY 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	444/933 (48%)
slc8a2b	XP_009290185.1	caca	47..967	CDD:273296	444/933 (48%)