Protein Alignment Calx and slc8a4b

DIOPT Version :10

• Sequence 1: NP_001247215.1
• Gene: Calx / 42481
• FlyBaseID: FBgn0013995
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001116712.1
• Gene: slc8a4b / 557499
• ZFINID: ZDB-GENE-050809-103
• Length: 925
• Species: Danio rerio
• Alignment Length: 942
• Identity: 438/942 - (46%)
• Similarity: 592/942 - (62%)
• Gaps: 121/942 - (12%)

  Fly    93 DAEELRE----------CSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMA 147
            ||::|.:          |::|::||:|.|| |.|||| :.|..||.|.|:|:|:|:||||||||.
Zfish    33 DAQDLDQSTSNCSQNDVCTDGVLLPVWNPQ-NPSVGDXVARAIVYLVALVYMFLGMSIIADRFMT 96

  Fly   148 AIEAITSIERAVVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDL 212
            |||.|||.|:.:..|.||.......||||||||:||||||||||||||||||||:...:||:|.|
Zfish    97 AIEVITSQEKEITTKRPNGETVTTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGSL 161

  Fly   213 GPGTIVGSAAYNLFMIIAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVIL 277
            ||.|||||||:|:|:||.:|:..:|.||.|:::|||||||||.:|:|||:||:|||:|.:||.:.
Zfish   162 GPSTIVGSAAFNMFVIIGLCVYVVPEGERRKVKHLRVFFVTAAWSMFAYIWLYLILAVISPGEVE 226

  Fly   278 VWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNK-RGTVVA--GEH----------DQVE 329
            ||||::|.|||||.|:.|:||:||||.|||..|.||.:| ||.:|:  ||.          |.:|
Zfish   227 VWEAVLTFLFFPLCVVQAWIADRRLLFYKYARKRYRTDKGRGIIVSEGGEELGKEAGFTKMDMLE 291

  Fly   330 MD-----------AEKGPKQPMVTSARGNDAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQ 383
            :|           .|.|        ..|.|.|  :|||||....|.||:|::|:.|:|||..||.
Zfish   292 IDGITTHLDGVLGGESG--------LGGRDQE--EEARREMARTLKELKQRHPEKDMEQLIEMAN 346

  Fly   384 EQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQERAHSDLTEVKAQLHAGDD-----------EE 437
            .|||.:..||||||||||||.|:|:||:::|                ||.|.           |:
Zfish   347 YQVLMQQQKSRAFYRIQATRMMIGAGNILKK----------------HAADQARKVVSSGEPREQ 395

  Fly   438 ADDP--IRMYFEPGHYTVMENCGEFEVRVVRR-GDISTYASVEYETQDGTASAGTDFVGRKGLLS 499
            .|||  .|:.|||..|...||||..::.|.|. ||......|:|.|:||||:||:|:...:|.|.
Zfish   396 EDDPHVTRIDFEPALYQCFENCGSLKLTVQRHGGDAGCSVKVDYRTEDGTANAGSDYEFAEGTLV 460

  Fly   500 FPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNP-----SEGVKLAVPM-------------IATV 546
            |.||.:.:...:.:||||:|||||.||:||.||     ::|..:|:..             .|||
Zfish   461 FKPGENVKDIAVGIIDDDIFEEDEYFYVRLSNPRIVGWADGHPIALETGAPAPSAALGEAHTATV 525

  Fly   547 MILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATESKDYEGARGEL 611
            .|.||||||||.|......::||:|..::||.|.|||||...|||.|...||...:|||...|:|
Zfish   526 TIYDDDHAGIFTFESESMRVSESIGIMQVKVQRTSGARGLAAVPYQTVEGTACGGEDYEEVSGKL 590

  Fly   612 VFENNESEKFIDLFILEESSYEKDVSFKVHIGEPRLAPDDTNKESFFNRFFEKHEHSGEPTHDEL 676
            .|:|:|:.|.|::.|:::..|||:.:|.:.:|||.|.           ...:||..|.| ...|:
Zfish   591 EFQNDETMKTIEVKIIDDEEYEKNKTFSIELGEPVLL-----------EIGQKHGDSNE-NKPEI 643

  Fly   677 AAKIKEVEKKPVQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTS 741
            .|:.:||.|              :..|..||.|...|.|.||.|||.|||||:.|.|::.|:|:|
Zfish   644 GAEEEEVAK--------------MGCPSLGEHTRLEVVIEESYEFKNTVDKLIKKTNLALVVGSS 694

  Fly   742 SWKEQFKDALTVIPADESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVV 806
            ||:|||..|:||...|:.|  .:..||.:||||.|:.||:.:||||||||||||:...|:..|:|
Zfish   695 SWREQFVSAVTVSAGDDDE--EESGEERLPSCFDYIMHFLTVFWKVLFAFVPPTEYWNGWACFIV 757

  Fly   807 SIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVT 871
            |||:||.:||:.||.||:|||.:.:||||||::|||||||:||||||.:||..|:.||..|||||
Zfish   758 SIFLIGALTAVTGDLASHFGCTVGLKDSVTAVVFVALGTSVPDTFASKVAAIQDQYADASIGNVT 822

  Fly   872 GSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGA 936
            ||||||||||||:||:|||:|..|.|.:|:|:||::.|:|.||...|::.:.::::||.....|.
Zfish   823 GSNAVNVFLGIGVAWSIAAIYWRSKGKSFHVDPGSLAFSVTLFTALAVVCVSVLLYRRRPSVAGG 887

  Fly   937 ELGGPKVSKYISAAILVFLWVFYVVICILEAY 968
            |||||:..|.:::.:.:.||:.|:::..||.|
Zfish   888 ELGGPRTCKILTSLLFISLWLIYILLASLETY 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	438/942 (46%)
slc8a4b	NP_001116712.1	caca	8..925	CDD:273296	438/942 (46%)