Protein Alignment Calx and Slc8a1

DIOPT Version :10

• Sequence 1: NP_001247215.1
• Gene: Calx / 42481
• FlyBaseID: FBgn0013995
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_035536.2
• Gene: Slc8a1 / 20541
• MGIID: 107956
• Length: 970
• Species: Mus musculus
• Alignment Length: 933
• Identity: 444/933 - (47%)
• Similarity: 611/933 - (65%)
• Gaps: 84/933 - (9%)

  Fly   100 CSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKGP 164
            |.:|::||:|.|| :.|.||::.|..||||.::|:|:||||||||||::||.|||.|:.:.:|.|
Mouse    52 CKKGVILPIWEPQ-DPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKP 115

  Fly   165 NNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMII 229
            |.......||||||||:||||||||||||||||||||:...:|.:|||||.|||||||:|:|:||
Mouse   116 NGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIII 180

  Fly   230 AVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLW 294
            |:|:..:|.||.|:|:|||||||||.:|:|||.||::||||.:|||:.|||.::|..|||:.|::
Mouse   181 ALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVSSPGVVEVWEGLLTFFFFPICVVF 245

  Fly   295 AYIAERRLLVYKYMDKNYRVNK-RGTVVAGEHD------QVEMDAEKGPKQPMVTS--------- 343
            |::|:||||.|||:.|.||..| ||.::..|.|      ::|||.:      :|.|
Mouse   246 AWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPASKTEIEMDGK------VVNSHVDNFLDGA 304

  Fly   344 ------ARGNDAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQAT 402
                  .|..|.|   |||||...:|.||:||:|:.::|||..:|..|||::..|||||||||||
Mouse   305 LVLEVDERDQDDE---EARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAFYRIQAT 366

  Fly   403 RKMVGSGNLMRKIQERAHSDLTEVKAQLHAGDDEEAD-DPI-RMYFEPGHYTVMENCGEFEVRVV 465
            |.|.|:||:::    |..:|.......:|..:.|.|: ||: :::||.|.|..:||||...:.::
Mouse   367 RLMTGAGNILK----RHAADQARKAVSMHEVNMEMAENDPVSKIFFEQGTYQCLENCGTVALTIM 427

  Fly   466 RR-GDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRL 529
            || ||:||...|::.|:||||:||:|:...:|.:.|.||..::..|:.:||||:|||||.|.:.|
Mouse   428 RRGGDLSTTVFVDFRTEDGTANAGSDYEFTEGTVIFKPGETQKEIRVGIIDDDIFEEDENFLVHL 492

  Fly   530 FN-------PSEGVK----------LAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKV 577
            .|       ..:|:.          |..|..||:.|.||||||||.|.:.|..::||:|..|:||
Mouse   493 SNVRVSSDVSEDGILESNHASSIACLGSPSTATITIFDDDHAGIFTFEEPVTHVSESIGIMEVKV 557

  Fly   578 MRYSGARGTVIVPYWTENDTAT-ESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVH 641
            :|.|||||.||:||.|...||. ..:|:|...|||.|:|:|..|.|.:.::::..|||:.:|.:.
Mouse   558 LRTSGARGNVIIPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFIE 622

  Fly   642 IGEPRLAPDD---------------TNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEKKPVQDL 691
            ||||||....               |.||.:....|.|......|....:....:|.:.|  |.|
Mouse   623 IGEPRLVEMSEKKALLLNELGGFTLTGKEMYGQPIFRKVHARDHPIPSTVITISEEYDDK--QPL 685

  Fly   692 T----ELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALT 752
            |    |..||..:.:|..||.|...|.|.||.|||:|||||:.|.|::.|:||:||:|||.:|:|
Mouse   686 TSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAIT 750

  Fly   753 VIPADESEFDNDDE--EEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVIT 815
            |   ...|.|:|||  ||::||||.||.||:.:||||||||||||:...|:..|:|||.:||::|
Mouse   751 V---SAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLT 812

  Fly   816 AIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFL 880
            |.|||.||:|||.:.:||||||::|||||||:||||||.:||..|:.||..||||||||||||||
Mouse   813 AFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFL 877

  Fly   881 GIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSK 945
            |||:||:|||:||:::|..|.|.|||:.|:|.||...|.|.:.::::|| ...||.|||||:.:|
Mouse   878 GIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRR-RPEIGGELGGPRTAK 941

  Fly   946 YISAAILVFLWVFYVVICILEAY 968
            .:::::.|.||:.|:....||||
Mouse   942 LLTSSLFVLLWLLYIFFSSLEAY 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	444/933 (48%)
Slc8a1	NP_035536.2	caca	1..970	CDD:273296	444/933 (48%)
		Alpha-1	138..178		29/39 (74%)
		Putative calmodulin-binding region. /evidence=ECO:0000250|UniProtKB:P23685	251..270		11/18 (61%)
		Alpha-2	839..875		26/35 (74%)