Protein Alignment Calx and FREM3

DIOPT Version :10

• Sequence 1: NP_001247215.1
• Gene: Calx / 42481
• FlyBaseID: FBgn0013995
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: NP_001161707.1
• Gene: FREM3 / 166752
• HGNCID: 25172
• Length: 2139
• Species: Homo sapiens
• Alignment Length: 790
• Identity: 164/790 - (20%)
• Similarity: 278/790 - (35%)
• Gaps: 214/790 - (27%)

  Fly    39 NVTSSSSSNLSQDDGHFLSRRLRQVSHGEEGD-EGAP----SQMDDELEQMTKVHGEAPDAEELR 98
            |:.::|..| |.|:.||...|...:.|.|..| .|.|    :|:.....:::.||  ..:.|:..
Human  1447 NLLTNSDIN-SSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH--TSNDEKKM 1508

  Fly    99 ECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163
            :..|..|:....|         :.|.|..|                       ||.::
Human  1509 DSFEFQVIGELYP---------VFRTFRIF-----------------------ITDVD------- 1534

  Fly   164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMI 228
              |.|.::       |:..|||....|.    |::::|:..:|.::    |..::      ||.|
Human  1535 --NKKPIL-------TIHRLTLQKEDSQ----LITLLELTVEDSDT----PDDLI------LFTI 1576

  Fly   229 IAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVL 293
            ..|.|            |.::.:..:.                                 |:|..
Human  1577 TQVPM------------HGKILYNGSR---------------------------------PVTTF 1596

  Fly   294 WAYIAERRLLVYKY-----MDKNYRVNKRGTVVAGEHDQ--VEMD---AEKGP------------ 336
            ......:.|:.||:     .:.::.:    ||..|.|..  |..|   |...|
Human  1597 TKQDLNKNLISYKHDGSETTEDSFSL----TVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDN 1657

  Fly   337 KQPMVTSARGNDAEAFDEARREYI-TLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQ 400
            :.|.:|:.||  |.|.......:: .|:|....|..|.|                 ......:.:
Human  1658 RLPQITTNRG--APALKRLHTGHMGFLITSKSLKAEDQD-----------------SPHRLLKYK 1703

  Fly   401 ATRK-------MVGSGNLMRKIQERAHSDLTEVKAQLHAGDDEEAD----------------DPI 442
            .||.       ..|.||...::..:|..|..::...|:.|.:...|                .|.
Human  1704 VTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPF 1768

  Fly   443 RMYF-----EPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKG-LLSFP 501
            .:.:     |..:|.|.|:....||.:.|||.:...:.:...|:|.||....||..:.. .:.|.
Human  1769 HLNWAWICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFN 1833

  Fly   502 PGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVKLAVPMIATVMILDDDHAGIFAFTDSVFEI 566
            ||.....:|:.:|.|:.:|..|.|.|.|..|...| |..|.:|||.|:|..........::.::|
Human  1834 PGQTTATWRVRIIPDNEYETSETFQIILSEPLMAV-LEFPEMATVEIVDPGDESTVYIPEAEYKI 1897

  Fly   567 TESVGRFELKVMRYSGARGTVIVPYWTENDTATES-------KDY----EGARGELVFENNESEK 620
            .|.:|...:.|.|...|...:||...|...:||.:       .||    |.....|.|:.||::|
Human  1898 EEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQK 1962

  Fly   621 FIDLFILEESSYEKDVSFKVH----IGEPRLAPDDTNKESFF-NRFFEKHEHSGEPTH--DELAA 678
            ...:.|:::|.||::.||.|.    :|....|...|.|.:.. :|:.|...|.|:..:  :|.|.
Human  1963 TCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESAR 2027

  Fly   679 KIKEVEKKPVQDLTELDRILLLSK---PRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLG- 739
            .::....:...||::...|.:.|:   ..:.|..|.||.|..:.:|...|.....:..:...||
Human  2028 YVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQ 2092

  Fly   740 -TSSWKEQFK 748
             |....|:|:
Human  2093 PTLEGPEKFE 2102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	164/790 (21%)
FREM3	NP_001161707.1	Frem_N	62..269	CDD:466034
		CSPG 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	306..409
		Cadherin_3	<323..424	CDD:465048
		Cadherin_3	416..524	CDD:465048
		CSPG 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	432..522
		Cadherin_3	526..608	CDD:465048
		CSPG 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	543..677
		Cadherin_3	686..808	CDD:465048
		CSPG 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	702..807
		Cadherin_3	812..922	CDD:465048
		CSPG 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	828..920
		CSPG 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	948..1040
		Cadherin_3	1058..1173	CDD:465048
		CSPG 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1069..1171
		Cadherin_3	1182..1287	CDD:465048
		CSPG 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1192..1285
		Cadherin_3	1289..1406	CDD:465048
		CSPG 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1306..1404
		Cadherin_3	1409..1515	CDD:465048	18/70 (26%)
		CSPG 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1425..1516		18/71 (25%)
		Cadherin_3	1524..1627	CDD:465048	29/204 (14%)
		CSPG 11. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1536..1625		22/158 (14%)
		Cadherin_3	1645..1757	CDD:465048	22/130 (17%)
		CSPG 12. /evidence=ECO:0000255|PROSITE-ProRule:PRU01201	1659..1756		21/115 (18%)
		caca	<1775..>1987	CDD:273296	61/212 (29%)
		Calx-beta	2011..2105	CDD:413355	20/92 (22%)