Protein Alignment Calx and Slc8a3

DIOPT Version :10

• Sequence 1: NP_001247215.1
• Gene: Calx / 42481
• FlyBaseID: FBgn0013995
• Length: 973
• Species: Drosophila melanogaster
• Sequence 2: XP_017449484.2
• Gene: Slc8a3 / 140448
• RGDID: 620197
• Length: 928
• Species: Rattus norvegicus
• Alignment Length: 935
• Identity: 442/935 - (47%)
• Similarity: 607/935 - (64%)
• Gaps: 82/935 - (8%)

  Fly    87 VHGEAPDAEELR----------------ECSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLF 135
            ::|...:|.:||                :|.||::||:|.|: |.|:||::.|..||||.|||:|
  Rat    25 LNGLRAEAGDLRDVPSAGQNNESCSGSSDCKEGVILPIWYPE-NPSLGDKIARVIVYFVALIYMF 88

  Fly   136 VGVSIIADRFMAAIEAITSIERAVVVKGPNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVI 200
            :|||||||||||:||.|||.||.|.:|.||.......:|:|||||:|||||||||||||||||:|
  Rat    89 LGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLI 153

  Fly   201 EIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLW 265
            |:....|.:|||||.|||||||:|:|:||.:|:..||.||.|:|:|||||||||.:|||||:||:
  Rat   154 EVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFVTAAWSVFAYIWLY 218

  Fly   266 LILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNK-RGTVV--AGEHDQ 327
            :||:||:|||:.|||.::||.|||:.||.|::|::|||.||||.|.||.:| ||.::  .|||.:
  Rat   219 MILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKRYRTDKHRGIIIETEGEHPK 283

  Fly   328 -VEMDAEKGPKQPMVTS--ARGN----DAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQ 385
             :|||.:      |:.|  ..||    :.:..||:|||.|.:|.:|:||:|:.||:||..||...
  Rat   284 GIEMDGK------MMNSHFLDGNLIPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYY 342

  Fly   386 VLARSSKSRAFYRIQATRKMVGSGNLMRK-IQERAHSDLTEVKAQLHAGDDEEADDPIRMYFEPG 449
            .|:...||||||||||||.|.|:||:::| ..|:|..  |...:::|.  ||..|...:::|:|.
  Rat   343 ALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKK--TASMSEVHT--DEPEDFASKVFFDPC 403

  Fly   450 HYTVMENCGEFEVRVVRR-GDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEV 513
            .|..:||||...:.|||: ||||....|:|:|:||:|:||.|:...:|.:...||..::.|.:.:
  Rat   404 SYQCLENCGAVLLTVVRKGGDISKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGI 468

  Fly   514 IDDDVFEEDECFYIRLFN--------------------PSEGVKLAVPMIATVMILDDDHAGIFA 558
            ||||:|||||.|::||.|                    |.....||.|.:|||.||||||||||.
  Rat   469 IDDDIFEEDEHFFVRLSNVRVEEEQLEEGMTPAILNSLPLPRAVLASPCVATVTILDDDHAGIFT 533

  Fly   559 FTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTAT-ESKDYEGARGELVFENNESEKFI 622
            |......::||:|..|:||:|.||||||||||:.|...||. ..:|:|...|||.|:|:|:.|.|
  Rat   534 FECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTI 598

  Fly   623 DLFILEESSYEKDVSFKVHIGEPRLAPDDTNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEKKP 687
            .:.::::.:|||:.::.:.:..||:......|....         |.|.|           ::|.
  Rat   599 HIKVIDDKAYEKNKNYVIEMMGPRMVDMSVQKALLL---------SPEVT-----------DRKL 643

  Fly   688 VQDLTELDRILLLSKPRNGELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALT 752
            ..:..|..||..:.||..||.....|.|.||.|||:|||||:.|.|::.|:||.||::||.:|:|
  Rat   644 TMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWRDQFMEAIT 708

  Fly   753 VIPADESEFDNDDEEEEVPSCFSYVSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAI 817
            |..|.:.| :::..||.:||||.||.||:.:|||||||.||||:.|.|:..|||||.:||::|||
  Rat   709 VSAAGDEE-EDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFVVSILIIGMLTAI 772

  Fly   818 IGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFLGI 882
            |||.||:|||.:.:||||||::|||.|||:||||||..||..|..||..||||||||||||||||
  Rat   773 IGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGI 837

  Fly   883 GLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSKYI 947
            ||||::||:|.:..|..|:|..||:.|:|.||...|.:.:.::::|| ...:|.|||||:..|..
  Rat   838 GLAWSVAAIYWAMQGQEFHVSAGTLAFSVTLFTIFAFVCLSVLLYRR-RPHLGGELGGPRGCKLA 901

  Fly   948 SAAILVFLWVFYVVICILEAYDVIR 972
            :..:.|.||:.||:...||||..|:
  Rat   902 TTWLFVSLWLLYVLFATLEAYCYIK 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Calx	NP_001247215.1	caca	4..973	CDD:273296	442/935 (47%)
Slc8a3	XP_017449484.2	caca	1..928	CDD:273296	442/935 (47%)