DRSC/TRiP Functional Genomics Resources

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Protein Alignment Calx and Slc8a2

DIOPT Version :10

Sequence 1:NP_001247215.1 Gene:Calx / 42481 FlyBaseID:FBgn0013995 Length:973 Species:Drosophila melanogaster
Sequence 2:NP_511174.2 Gene:Slc8a2 / 140447 RGDID:620194 Length:921 Species:Rattus norvegicus


Alignment Length:911 Identity:431/911 - (47%)
Similarity:591/911 - (64%) Gaps:78/911 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 CSEGLVLPLWMPQRNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKGP 164
            |..|::||:|.|. :.|:||:..|..||||.::|:|:|||||||||||:||.|||.|:.:.:...
  Rat    49 CQPGVLLPVWEPD-DPSLGDKAARAVVYFVAMVYMFLGVSIIADRFMASIEVITSKEKEITITKA 112

  Fly   165 NNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMII 229
            |....|..||||||||:||||||||||||||||||||:...:|::|:|||||||||||:|:|::|
  Rat   113 NGETSVGTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFQAGELGPGTIVGSAAFNMFVVI 177

  Fly   230 AVCMIWIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLW 294
            |||:..|||||.|:|:|||||||||.:|:||||||:|||:||:|||:.||||::||:|||:.|::
  Rat   178 AVCVYVIPAGESRKIKHLRVFFVTASWSIFAYVWLYLILAVFSPGVVQVWEALLTLVFFPVCVVF 242

  Fly   295 AYIAERRLLVYKYMDKNYRVNKR-GTVVAGEHD---QVEMDAE-KGPKQPMVTSARGN---DAEA 351
            |::|::|||.|||:.|.||.:.| |.::..|.|   .:|:|.. .|.:.|....|.|.   :|..
  Rat   243 AWMADKRLLFYKYVYKRYRTDPRSGIIIGAEGDPPKSIELDGTFVGTEVPGELGALGTGPAEARE 307

  Fly   352 FDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQ 416
            .|.:|||.|.:|.:|:||:||.|||||..:|:...|....||||||||||||.|.|:||::|:  
  Rat   308 LDASRREVIQILKDLKQKHPDKDLEQLVGIAKYYALLHQQKSRAFYRIQATRLMTGAGNVLRR-- 370

  Fly   417 ERAHSDLTEVKAQLHAGD------------DEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRG- 468
                          ||.|            |:|.|...|::|||..|..:||||...:.|..:| 
  Rat   371 --------------HAADAARRPGANDGAPDDEDDGASRIFFEPSLYHCLENCGSVLLSVACQGG 421

  Fly   469 -DISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFN- 531
             ..||: .|:|.|:||:|.||:|:...:|.|.|.||..::..||.:||||:|||||.|::||.| 
  Rat   422 EGNSTF-YVDYRTEDGSAKAGSDYEYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNL 485

  Fly   532 ---PSEGV-----------KLAVPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSG 582
               .::|:           :|..|::|||.||||||||||:|.|.:..::|.:|..:::|:|.||
  Rat   486 RVGDAQGMFEPDGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSG 550

  Fly   583 ARGTVIVPYWTENDTAT-ESKDYEGARGELVFENNESEKFIDLFILEESSYEKDVSFKVHIGEPR 646
            |||||.:||.|.:.||. ....||.|.|||.|.::|:.|.:.:.|:::..|||..:|.:.:|:|:
  Rat   551 ARGTVRLPYRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDDEEYEKKDNFFIELGQPQ 615

  Fly   647 LAPDDTNKESFFNRFFEKHEHSGEPTHDELAAKIKEVEKKPVQDLTELDRILLLSKPRNGELTTA 711
                      :..|..           ..|.....:.::|...:..|..||..:.||..||....
  Rat   616 ----------WLKRGI-----------SALLLNQGDGDRKLTAEEEEAQRIAEMGKPVLGENCRL 659

  Fly   712 YVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPADESEFDNDDEEEEVPSCFSY 776
            .|.|.||.:||.|||||:.|.|::.|:||.||:|||.:|:||...||.|.::...||.:||||.|
  Rat   660 EVIIEESYDFKNTVDKLIKKTNLALVIGTHSWREQFLEAVTVSAGDEEEDEDGSREERLPSCFDY 724

  Fly   777 VSHFVCLFWKVLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFV 841
            |.||:.:|||||||.||||:.|.|:..|.|.|.|||::||:|||.||:|||.:.:||||.|::||
  Rat   725 VMHFLTVFWKVLFACVPPTEYCHGWACFGVCILVIGLLTALIGDLASHFGCTVGLKDSVNAVVFV 789

  Fly   842 ALGTSIPDTFASMIAAKHDEGADNCIGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGT 906
            ||||||||||||.:||..|:.||..|||||||||||||||:|:||::||||.:..|..|.|..||
  Rat   790 ALGTSIPDTFASKVAALQDQCADASIGNVTGSNAVNVFLGLGVAWSVAAVYWAVQGRPFEVRTGT 854

  Fly   907 IGFAVALFCGEALIAIMLIMFRRWHKGIGAELGGPKVSKYISAAILVFLWVFYVVICILEAYDVI 971
            :.|:|.||...|.:.|.::::|| ...||.|||||:..|..:.|:.:.||..|::...||||..|
  Rat   855 LAFSVTLFTVFAFVGIAVLLYRR-RPHIGGELGGPRGPKLATTALFLGLWFLYILFASLEAYCHI 918

  Fly   972 R 972
            |
  Rat   919 R 919

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalxNP_001247215.1 caca 4..973 CDD:273296 431/911 (47%)
Slc8a2NP_511174.2 caca 1..921 CDD:273296 431/911 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 23..42
Alpha-1 135..175 29/39 (74%)
Putative calmodulin-binding region. /evidence=ECO:0000250|UniProtKB:P23685 248..267 10/18 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 372..391 4/18 (22%)
Alpha-2 790..826 27/35 (77%)
Blue background indicates that the domain is not in the aligned region.

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