Protein Alignment Oct-TyrR and htr1ab

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_001139238.1
• Gene: htr1ab / 797538
• ZFINID: ZDB-GENE-090409-2
• Length: 403
• Species: Danio rerio
• Alignment Length: 506
• Identity: 148/506 - (29%)
• Similarity: 224/506 - (44%)
• Gaps: 142/506 - (28%)

  Fly   100 LQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLP 164
            |.:.||....:.|:|::..:|:.:|.||..|:.::...:.|:.|.|:.|.||||.||.|::||||
Zfish    26 LPVKVPLSYQISTSLLIGALILCSIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLP 90

  Fly   165 FNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLL 229
            ....|.:|.:|..|...|.::::.|:||||||||:||||||||||||||||:|.:|||:.|..||
Zfish    91 MAALYQVLDKWTLGQVTCDIFISLDILCCTSSILHLCAIALDRYWAITDPIDYMKKRTLKRAALL 155

  Fly   230 ISGVWLLSLLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFV 294
            |:..|.:...||.||::.....|      ..|.::....|.|||:..:|:|||.:|.::|..||.
Zfish   156 ITVTWFVGFSISIPPMLIMKSQP------KTCMISHDPWYTIYSTFCAFYIPLILMLVLYGRIFK 214

  Fly   295 ATRRRLRERARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQ 359
            |.|.|:|:..|
Zfish   215 AARFRIRKTVR------------------------------------------------------ 225

  Fly   360 NDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTC 424
                       :|:                      ||..:..|.......:..|.......|..
Zfish   226 -----------KPE----------------------KKRVKCLTVSPALFKRANGELSKNWKSAV 257

  Fly   425 EPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQ 489
            ||                                      .|..|:...:..|::..||::....
Zfish   258 EP--------------------------------------KPAACVNGAIKHAEDGESLEIIEVH 284

  Fly   490 SSTGVAAVSVTPLQKKTSGVNQF-------IEEKQKISLSKERRAARTLGIIMGVFVICWLPFFL 547
            |:    :.:..||....:.|..|       .|.|:|::|::||:..:|||||||.|::||||||:
Zfish   285 SN----SKNNLPLPNTPNSVPLFENKHEKNTEAKRKLALARERKTVKTLGIIMGTFILCWLPFFI 345

  Fly   548 MYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            ..:::|||.||......::.|.||||.||.|||:||..||.|::.|||:::
Zfish   346 KALVMPFCPTCVMPLWLQDVINWLGYSNSLLNPIIYAYFNKDFQSAFKKII 396

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	78/183 (43%)
		TM helix 1	111..137	CDD:320188	7/25 (28%)
		TM helix 2	144..170	CDD:320188	13/25 (52%)
		TM helix 3	182..212	CDD:320188	21/29 (72%)
		TM helix 4	224..247	CDD:320188	9/22 (41%)
		TM helix 5	266..294	CDD:320188	11/27 (41%)
		7tm_GPCRs	<519..594	CDD:475119	37/74 (50%)
		TM helix 6	528..550	CDD:410628	14/21 (67%)
		TM helix 7	562..587	CDD:410628	12/24 (50%)
htr1ab	NP_001139238.1	7tm_GPCRs	36..392	CDD:475119	142/490 (29%)
		TM helix 1	38..62	CDD:320453	7/23 (30%)
		TM helix 2	71..93	CDD:320453	13/21 (62%)
		TM helix 3	109..131	CDD:320453	13/21 (62%)
		TM helix 4	154..170	CDD:320453	6/15 (40%)
		TM helix 5	187..210	CDD:320453	9/22 (41%)
		TM helix 6	326..348	CDD:320453	14/21 (67%)
		TM helix 7	360..385	CDD:320453	12/24 (50%)