DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oct-TyrR and adra2db

DIOPT Version :9

Sequence 1:	NP_001163494.1	Gene:	Oct-TyrR / 42452	FlyBaseID:	FBgn0004514	Length:	601	Species:	Drosophila melanogaster
Sequence 2:	NP_919346.1	Gene:	adra2db / 266755	ZFINID:	ZDB-GENE-021010-5	Length:	415	Species:	Danio rerio

Alignment Length:	536	Identity:	159/536 - (29%)
Similarity:	247/536 - (46%)	Gaps:	133/536 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 LTTVTAALSTAQADKDSAGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILV 130
            |:|:|..|..:..|.:.............||:             |..||::|||::||:||:||
Zfish     3 LSTITFLLPNSSEDTNGTSAPRLPPHSQCASV-------------LIVLVVTVIILVTIVGNVLV 54

  Fly   131 ILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTS 195
            :::|||.:.||..||.|:||||.||:.||.||:||::|..::|.|..|...|..:|..|||.|||
Zfish    55 VVAVFTSRALRAPQNLFLVSLAAADILVATLVIPFSLANEVMGYWYLGSTWCAFYLALDVLFCTS 119

  Fly   196 SILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPDEFTSATP 260
            ||::||||:|||||::|..::|..|||..|:.::|:.||::|.:||.|||:....  ||.    .
Zfish   120 SIVHLCAISLDRYWSVTKAVSYNLKRTPRRIKIMITVVWVISAVISFPPLLMTKH--DEL----E 178

  Fly   261 CELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANS 325
            |.|.::..|::.|.:.|||.|..||.:||..|:...::|                         :
Zfish   179 CLLNNETWYILSSCIVSFFAPGLIMILVYCRIYRVAKQR-------------------------A 218

  Fly   326 SPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISS-ETHQPQDSSKAGPHGNSDPQQQ 389
            |.|..:.:|.:           |..:|..|..::..:..:.| .:|......:.|...:.|.::.
Zfish   219 STVFVAKNGME-----------RQPSQSETCFVRKGKSEVESPSSHSSGSRERKGELDDIDLEES 272

  Fly   390 HVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKS 454
            .|....:.||.||:            ||.:.:.:|.                 :|.|..|.....
Zfish   273 SVSNRHRNSRFAKS------------RKVEGAQSCP-----------------KPNGRLSWACSR 308

  Fly   455 DAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKI 519
            .:|:..|    |:.          .|.||                               .|.|:
Zfish   309 ASELEQE----PRA----------RQLSL-------------------------------SKSKL 328

  Fly   520 SLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCC--PTNKFKNFITWLGYINSGLNPVI 582
            :..:|:|....|.::|||||:||.|||..|.:...|:..|  |.:.| |...|:||.||.:||:|
Zfish   329 AQMREKRFTFVLAVVMGVFVLCWFPFFFTYSLHAICRKSCTIPDSLF-NLFFWIGYCNSSVNPII 392

  Fly   583 YTIFNLDYRRAFKRLL 598
            |||||.|:|:|||:::
Zfish   393 YTIFNRDFRKAFKKIM 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	66/130 (51%)
Oct-TyrR	NP_001163494.1	7tm_1	126..>293	CDD:278431	76/166 (46%)
adra2db	NP_919346.1	7tm_1	59..393	CDD:278431	128/450 (28%)
		7tm_4	69..>226	CDD:304433	70/187 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..299		14/93 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D323202at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24314
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.020