Protein Alignment Oct-TyrR and adra2da

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_919345.2
• Gene: adra2da / 266754
• ZFINID: ZDB-GENE-021010-4
• Length: 408
• Species: Danio rerio
• Alignment Length: 494
• Identity: 158/494 - (31%)
• Similarity: 228/494 - (46%)
• Gaps: 136/494 - (27%)

  Fly   114 LVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEFG 178
            ||:|:||:|||:||:|||::|.|.:.||..||.|:||||.||:.||.||:||::|..|:|.|.||
Zfish    35 LVVSLIILLTIVGNVLVIVAVLTSRALRAPQNLFLVSLACADILVATLVIPFSLANEIMGYWYFG 99

  Fly   179 IHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWLLSLLISSP 243
            ...|..:|..|||.|||||::||||:|||||::|..:.|..|||..|:..:|:.|||:|.:||.|
Zfish   100 STWCAFYLALDVLFCTSSIVHLCAISLDRYWSVTKAVRYNLKRTPRRIKCMIAVVWLISAVISFP 164

  Fly   244 PLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRERARANK 308
            |||....  ||    ..|.:..:..|::.|...|||.|..||..||.:|:...::|
Zfish   165 PLIMTKH--DE----KECLINDETWYILSSCAVSFFAPGLIMITVYCKIYRVAKQR--------- 214

  Fly   309 LNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQ 373
                            ||.|..:.:|.:           |..:|..|..::.|:
Zfish   215 ----------------SSTVFVAKNGLE-----------RQPSQSETCFVRKDK----------- 241

  Fly   374 DSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSI-------KHGKTRGGRKSQSSSTCEPHGEQQ 431
             ..|..|..||.          :.::|.:..|.|       ...:.||.|.|:....   .||::
Zfish   242 -FEKESPSSNSS----------ESAQRQEELDDIDLEESAASDSRARGSRFSKRRRV---EGERR 292

  Fly   432 LLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSSTGVAA 496
                 |...||:              :|..:..:| |..|
Zfish   293 -----GPQRSCR--------------VSWAAHQEP-GSRQ------------------------- 312

  Fly   497 VSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQTCC-- 559
                          |.:..|.|::..:|:|....|.::|||||:||.|||..|.:...|...|
Zfish   313 --------------QQLASKSKVAQMREKRFTFVLAVVMGVFVLCWFPFFFTYSLQAVCGERCGP 363

  Fly   560 PTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            |...||.|. |:||.||.:||:||||||.|:|:|||:::
Zfish   364 PEALFKLFF-WIGYCNSSVNPIIYTIFNRDFRKAFKKVV 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	88/179 (49%)
		TM helix 1	111..137	CDD:320188	14/22 (64%)
		TM helix 2	144..170	CDD:320188	16/25 (64%)
		TM helix 3	182..212	CDD:320188	19/29 (66%)
		TM helix 4	224..247	CDD:320188	11/22 (50%)
		TM helix 5	266..294	CDD:320188	11/27 (41%)
		7tm_GPCRs	<519..594	CDD:475119	35/76 (46%)
		TM helix 6	528..550	CDD:410628	11/21 (52%)
		TM helix 7	562..587	CDD:410628	14/24 (58%)
adra2da	NP_919345.2	7tmA_alpha-2D_AR	44..397	CDD:320447	149/479 (31%)
		TM helix 2	65..91	CDD:320447	16/25 (64%)
		TM helix 3	103..133	CDD:320447	19/29 (66%)
		TM helix 4	145..168	CDD:320447	11/22 (50%)
		TM helix 5	181..210	CDD:320447	11/28 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	242..306		17/95 (18%)
		TM helix 6	324..354	CDD:320447	14/29 (48%)
		TM helix 7	365..390	CDD:320447	14/25 (56%)