Protein Alignment Oct-TyrR and adra2a

DIOPT Version :10

• Sequence 1: NP_524419.2
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_997520.4
• Gene: adra2a / 266750
• ZFINID: ZDB-GENE-021010-1
• Length: 388
• Species: Danio rerio
• Alignment Length: 497
• Identity: 162/497 - (32%)
• Similarity: 229/497 - (46%)
• Gaps: 144/497 - (28%)

  Fly   110 LLTALVLSV----IIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYS 170
            ||.||.|||    :|:|.|.||:|||::|||.:.||..||.|:||||.||:.||.||:||::|..
Zfish    19 LLVALPLSVAVGLLILLIIFGNVLVIIAVFTSRALRAPQNLFLVSLASADILVATLVMPFSLANE 83

  Fly   171 ILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQKRTVGRVLLLISGVWL 235
            ::|.|.||...|:::|..|||.||:||.:||||:|||||:||..|.|..|||..|:..:|..||:
Zfish    84 LMGMWTFGGVWCEIYLALDVLFCTASITHLCAISLDRYWSITQAIEYNLKRTPQRIKRIIFIVWI 148

  Fly   236 LSLLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRL 300
            ::.:||.||||....     :....|::..::.|::.|.:||||:|..||.:|||.|:...::|.
Zfish   149 IAAVISCPPLITMKK-----SEGDICDINKEKWYIVSSCIGSFFLPCIIMVLVYIRIYQIAKKRT 208

  Fly   301 RERARANKLNTIALKSTE----LEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQND 361
            |.....::.|.:..|..:    |..:.|:.|                                .|
Zfish   209 RAPPGDHRKNEVGKKENDPHEKLNGIQNAEP--------------------------------ED 241

  Fly   362 QESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEP 426
            ::.|:.   ...:.|.:..|..|:|     ..|.|||.:.|||.|
Zfish   242 KDEING---VDMEESSSSDHKVSNP-----CSLKKKSSKGKTKLS-------------------- 278

  Fly   427 HGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSS 491
                |:.|..||              |::| ..|...|..||
Zfish   279 ----QIKPGDGD--------------KTEA-CQTTKASRWKG----------------------- 301

  Fly   492 TGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQ 556
                                    :|    ::|:|....|.:::|||||||.|||..|....||.
Zfish   302 ------------------------RQ----NREKRFTFVLAVVIGVFVICWFPFFFTYTFTAFCD 338

  Fly   557 TCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            .|.|...|| |..|.||.||.|||:||||||.|:||:||::|
Zfish   339 CCVPETLFK-FFFWFGYCNSSLNPIIYTIFNNDFRRSFKKIL 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_524419.2	7tmA_tyramine_octopamine_R-like	110..>294	CDD:320188	89/187 (48%)
		TM helix 1	111..137	CDD:320188	16/29 (55%)
		TM helix 2	144..170	CDD:320188	16/25 (64%)
		TM helix 3	182..212	CDD:320188	18/29 (62%)
		TM helix 4	224..247	CDD:320188	9/22 (41%)
		TM helix 5	266..294	CDD:320188	13/27 (48%)
		7tm_GPCRs	<519..594	CDD:475119	38/74 (51%)
		TM helix 6	528..550	CDD:410628	11/21 (52%)
		TM helix 7	562..587	CDD:410628	15/24 (63%)
adra2a	NP_997520.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	208..291		26/161 (16%)