Protein Alignment Oct-TyrR and Drd2

DIOPT Version :8

• Sequence 1: NP_001163494.1
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_036679.1
• Gene: Drd2 / 24318
• RGDID: 2520
• Length: 444
• Species: Rattus norvegicus
• Alignment Length: 510
• Identity: 158/510 - (30%)
• Similarity: 246/510 - (48%)
• Gaps: 129/510 - (25%)

  Fly   113 ALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGRWEF 177
            |::|:::|.:.:.||:||.::|...|.|:...|:.|||||||||.||.||:|:.|...::|.|:|
  Rat    38 AMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKF 102

  Fly   178 G-IHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPI----NYAQKRTVGRVLLLISGVWLLS 237
            . || |.:::|.||:.||:||||||||::|||.|:..|:    .|:.||   ||.::|:.||:||
  Rat   103 SRIH-CDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKR---RVTVMIAIVWVLS 163

  Fly   238 LLISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRE 302
            ..||.|.|.|.|:     |....| :.:...:|:|||:.||::|..:..:|||:|::..|:| |:
  Rat   164 FTISCPLLFGLNN-----TDQNEC-IIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKR-RK 221

  Fly   303 RA---------RANKLNTIALKSTELEPMANSSPVAASNSG---SKSRLLASWLCCGRDRAQFAT 355
            |.         |||....:....|..|.|...:.:..||..   ::.|:.|:      .|||
  Rat   222 RVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAA------RRAQ--- 277

  Fly   356 PMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQS 420
               :.:.|.:||.:  |.:.::..|    .|...|.:.|...|..              |..|..
  Rat   278 ---ELEMEMLSSTS--PPERTRYSP----IPPSHHQLTLPDPSHH--------------GLHSNP 319

  Fly   421 SSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEIST-------ESGSDPKGCIQVCVTQAD 478
            .|..:|.                 ..||       |:|..       |..:.|.|         .
  Rat   320 DSPAKPE-----------------KNGH-------AKIVNPRIAKFFEIQTMPNG---------K 351

  Fly   479 EQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWL 543
            .:||||..                            .::|:|..||::|.:.|.|::|||:||||
  Rat   352 TRTSLKTM----------------------------SRRKLSQQKEKKATQMLAIVLGVFIICWL 388

  Fly   544 PFFLMYVILPFCQTCCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            |||:.:::...|....|...:..| |||||:||.:||:|||.||:::|:||.::|
  Rat   389 PFFITHILNIHCDCNIPPVLYSAF-TWLGYVNSAVNPIIYTTFNIEFRKAFMKIL 442

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	62/135 (46%)
		7tm_1	126..>293	CDD:278431	75/171 (44%)
Drd2	NP_036679.1	7tmA_D2_dopamine_R	35..438	CDD:320435	155/504 (31%)
		TM helix 1	36..62	CDD:320435	8/23 (35%)
		TM helix 2	69..92	CDD:320435	15/22 (68%)
		TM helix 3	107..137	CDD:320435	18/29 (62%)
		TM helix 4	152..170	CDD:320435	8/17 (47%)
		TM helix 5	186..211	CDD:320435	9/24 (38%)
		Agonist binding. {ECO:0000250}	190..197		4/6 (67%)
		Interaction with PPP1R9B. {ECO:0000269|PubMed:10391935}	211..374		47/256 (18%)
		TM helix 6	367..397	CDD:320435	15/29 (52%)
		Agonist binding. {ECO:0000250}	387..395		5/7 (71%)
		TM helix 7	406..431	CDD:320435	13/25 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0000677
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000