Protein Alignment Oct-TyrR and DRD3

DIOPT Version :8

• Sequence 1: NP_001163494.1
• Gene: Oct-TyrR / 42452
• FlyBaseID: FBgn0004514
• Length: 601
• Species: Drosophila melanogaster
• Sequence 2: NP_000787.2
• Gene: DRD3 / 1814
• HGNCID: 3024
• Length: 400
• Species: Homo sapiens
• Alignment Length: 496
• Identity: 147/497 (30%)
• Similarity: 223/497 (45%)
• Gaps: 140/497 (28%)

  Fly   113 ALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFFIVSLAVADLTVALLVLPFNVAYSILGR-WE 176
            ||....:|:..:.||.||.::|...:.|:...|:.:||||||||.||.||:|:.|...:.|. |.
Human    33 ALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWN 97

  Fly   177 FGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAITDPINYAQ---KRTVGRVLLLISGVWLLSL 238
            |....|.:::|.||:.||:||||||||::|||.|:..|::|..   :.:..||.|:|:.||:|:.
Human    98 FSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAF 162

  Fly   239 LISSPPLIGWNDWPDEFTSATPCELTSQRGYVIYSSLGSFFIPLAIMTIVYIEIFVATRRRLRER 303
            .:|.|.|.|:|...|    .|.|.: |...:|||||:.||::|..:..:||..|:|..::|.|:|
Human   163 AVSCPLLFGFNTTGD----PTVCSI-SNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKR 222

  Fly   304 ARANKLNTIALKSTELEPMANSSPVAASNSGSKSRLLASWLCCGRDRAQFATPMIQNDQESISSE 368
            ....:               ||.                   |...|..|....:..|...:..:
Human   223 ILTRQ---------------NSQ-------------------CNSVRPGFPQQTLSPDPAHLELK 253

  Fly   369 THQP--QDSSKAGP----HGNSDPQQQHVVVLVKKSRRAKTKDSIKHGKTRGGRKSQSSSTCEPH 427
            .:..  ||::..||    .|.            :..|..||::|:             |.|..|
Human   254 RYYSICQDTALGGPGFQERGG------------ELKREEKTRNSL-------------SPTIAP- 292

  Fly   428 GEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGSDPKGCIQVCVTQADEQTSLKLTPPQSST 492
                                         ::|.|......|.:         .|||||.|.| ..
Human   293 -----------------------------KLSLEVRKLSNGRL---------STSLKLGPLQ-PR 318

  Fly   493 GVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAARTLGIIMGVFVICWLPFFLMYVILPFCQT 557
            ||      ||                    :|::|.:.:.|::|.|::|||||||.:|:...|||
Human   319 GV------PL--------------------REKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQT 357

  Fly   558 CCPTNKFKNFITWLGYINSGLNPVIYTIFNLDYRRAFKRLL 598
            |..:.:..:..|||||:||.|||||||.||:::|:||.::|
Human   358 CHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKIL 398

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oct-TyrR	NP_001163494.1	Zinc_peptidase_like	<113..244	CDD:301362	56/135 (41%)
		7tm_1	126..>293	CDD:278431	71/171 (42%)
DRD3	NP_000787.2	7tm_4	44..>216	CDD:304433	72/177 (41%)
		7tm_1	46..383	CDD:278431	136/467 (29%)
		Agonist binding	189..196		5/7 (71%)
		Agonist binding	342..350		6/8 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000				FOG0000677
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000