DRSC/TRiP Functional Genomics Resources

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Protein Alignment Oct-TyrR and ADRA2C

DIOPT Version :10

Sequence 1:NP_524419.2 Gene:Oct-TyrR / 42452 FlyBaseID:FBgn0004514 Length:601 Species:Drosophila melanogaster
Sequence 2:NP_000674.2 Gene:ADRA2C / 152 HGNCID:283 Length:462 Species:Homo sapiens


Alignment Length:591 Identity:184/591 - (31%)
Similarity:270/591 - (45%) Gaps:155/591 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 AAALTAAAAVSTTKSGSGNAARGYTDSDDDAGMGTEAVANISGSLVEGLTTVTAALSTAQADKDS 82
            ||||..|||.....||:|.             .|:..|||.||:                    |
Human     7 AAALAVAAAAGPNASGAGE-------------RGSGGVANASGA--------------------S 38

  Fly    83 AGECEGAVEELHASILGLQLAVPEWEALLTALVLSVIIVLTIIGNILVILSVFTYKPLRIVQNFF 147
            .|...|....  .::.||            |.|:..:||.|::||:||:::|.|.:.||..||.|
Human    39 WGPPRGQYSA--GAVAGL------------AAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLF 89

  Fly   148 IVSLAVADLTVALLVLPFNVAYSILGRWEFGIHLCKLWLTCDVLCCTSSILNLCAIALDRYWAIT 212
            :||||.||:.||.||:||::|..::..|.||...|.::|..|||.|||||::||||:|||||::|
Human    90 LVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVT 154

  Fly   213 DPINYAQKRTVGRVLLLISGVWLLSLLISSPPLIGWNDWPDEFTSATP-CELTSQRGYVIYSSLG 276
            ..:.|..|||..||...|..|||:|.:||.|||:.....||  .:|.| |.|..:..|::.|.:|
Human   155 QAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPD--GAAYPQCGLNDETWYILSSCIG 217

  Fly   277 SFFIPLAIMTIVYIEIFVATRRRLRERARANKLNTIALKSTELEPMANSSPV------AASNSGS 335
            |||.|..||.:||..|:...:.|.|         |::.|...:.| ..:||.      ||:.:|.
Human   218 SFFAPCLIMGLVYARIYRVAKLRTR---------TLSEKRAPVGP-DGASPTTENGLGAAAGAGE 272

  Fly   336 KSRLLASWLCCGRDRAQFATPMIQNDQESISSETHQPQDSSKAGPHGNSDPQQQHVVVLVKKSRR 400
            ...       |....|.     ::.|:.|.::|                           ::.||
Human   273 NGH-------CAPPPAD-----VEPDESSAAAE---------------------------RRRRR 298

  Fly   401 AKTKDSIKHGKTRGGRKSQSSSTCEPHGEQQLLPAGGDGGSCQPGGGHSGGGKSDAEISTESGS- 464
            ...:        ||||:.                ||.:||:....|..:|.|.:::...|.|.| 
Human   299 GALR--------RGGRRR----------------AGAEGGAGGADGQGAGPGAAESGALTASRSP 339

  Fly   465 DPKGCIQVCVTQADEQTSLKLTPPQSSTGVAAVSVTPLQKKTSGVNQFIEEKQKISLSKERRAAR 529
            .|.|.:.                 ::|:......::..::..|.|.     ::|::.::|:|...
Human   340 GPGGRLS-----------------RASSRSVEFFLSRRRRARSSVC-----RRKVAQAREKRFTF 382

  Fly   530 TLGIIMGVFVICWLPFFLMYVILPFCQTCC--PTNKFKNFITWLGYINSGLNPVIYTIFNLDYRR 592
            .|.::|||||:||.|||..|.:...|:..|  |...|| |..|:||.||.|||||||:||.|:||
Human   383 VLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK-FFFWIGYCNSSLNPVIYTVFNQDFRR 446

  Fly   593 AFKRLL 598
            :||.:|
Human   447 SFKHIL 452

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Oct-TyrRNP_524419.2 7tmA_tyramine_octopamine_R-like 110..>294 CDD:320188 86/184 (47%)
TM helix 1 111..137 CDD:320188 10/25 (40%)
TM helix 2 144..170 CDD:320188 16/25 (64%)
TM helix 3 182..212 CDD:320188 19/29 (66%)
TM helix 4 224..247 CDD:320188 12/22 (55%)
TM helix 5 266..294 CDD:320188 12/27 (44%)
7tm_GPCRs <519..594 CDD:475119 37/76 (49%)
TM helix 6 528..550 CDD:410628 11/21 (52%)
TM helix 7 562..587 CDD:410628 15/24 (63%)
ADRA2CNP_000674.2 7tmA_alpha2C_AR 60..448 CDD:320446 158/485 (33%)
TM helix 2 86..112 CDD:320446 16/25 (64%)
TM helix 3 124..154 CDD:320446 19/29 (66%)
TM helix 4 166..189 CDD:320446 12/22 (55%)
TM helix 5 207..236 CDD:320446 12/28 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 246..347 30/181 (17%)
TM helix 6 375..405 CDD:320446 14/29 (48%)
TM helix 7 416..441 CDD:320446 15/25 (60%)

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