Protein Alignment Pi3K92E and pik3cg

DIOPT Version :10

• Sequence 1: NP_650902.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Sequence 2: XP_012814080.1
• Gene: pik3cg / 100158519
• XenbaseID: XB-GENE-1011009
• Length: 1126
• Species: Xenopus tropicalis
• Alignment Length: 1002
• Identity: 336/1002 - (33%)
• Similarity: 525/1002 - (52%)
• Gaps: 114/1002 - (11%)

  Fly   139 ELTKMVNGMIG-TTFDHNRTHGSPEIDDFRLYMTQ----TCDNIELERSAYTWQQRLLYEHPLRL 198
            |..|.:|.:|| ...|.:..|      |..|..|:    |...|||.|.    ..||....|...
 Frog   165 EYQKTLNYLIGYDVTDVSNVH------DDELEFTRRRLVTPRMIELSRR----DARLYSMDPWVT 219

  Fly   199 ANSTKMPELIRERHPTRTFLIVVKNENDQSTFTLSVNEQDTPFSLTESTLQKM--NRSQMKMNDR 261
            ..|  :||.:.:|..:.:..|::  ....::.|:.|:..|||..:..|...||  .:|.:.:::.
 Frog   220 CKS--LPEYLCQRIISNSIFIII--HKGMTSHTIRVSIDDTPDVILHSFFTKMAKKKSLLDISEE 280

  Fly   262 TS--DYILKVSGRDEYLLGDYPLIQFLYIQEMLSDSAVPNVVLQ-------SVYRLESY------ 311
            .|  |::|:|.|||||::|:.|:..|.:|::.:.:....::||:       ...:.|.:
 Frog   281 NSELDFVLRVCGRDEYIIGNAPIKDFHWIRQCIKNGQEIHLVLEKPPDPLMDEVQKEQWPLVDDC 345

  Fly   312 --INHHNEQAMVTKRPLPKKRTVHLHKSISSLWDMGNYFQLTLHSISNVNFDKTRALKVGVHVCL 374
              :..::||..:..:...|..|:       ||||....|::.:..|......|...|...|...:
 Frog   346 TGVTGYHEQLTIEGKDHEKIFTI-------SLWDCNRKFRVKIIGIDIPVLPKNTELIAFVEANI 403

  Fly   375 YHGDKKLCAQRSTDSPNGNF-DTFLFNDLVMDFDIQMRNLPRMTRLCIVIFEVTKMSRSKKS-SN 437
            .||.:.|..:|:|..|   | :..|:|.. ::|||::::||:...|.:.||.....:.|.|| ..
 Frog   404 QHGQQVLSQRRTTCKP---FTEEVLWNSW-LEFDIKIKDLPKGALLNLQIFCGKAPTASNKSIVQ 464

  Fly   438 NKDIALKDVPYNKNPLAWVNTTIFDHKDILRTGRHTLYTWTY-----------ADDIQSVEVFHP 491
            :.:....|.......|.:||..:.||:.:||.|.:.|:.|..           ||.:.|.
 Frog   465 SPESTASDSKCKNQLLYYVNLLLIDHRFLLRQGEYVLHMWKIPGKGEEQGSINADKLTSA----- 524

  Fly   492 LGTIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADR---EQVNRLQRQLAGPEKPIKE 553
                 .||.||....:.:: |......|..|..::|.....:|   |..|:|:          |:
 Frog   525 -----TNPDKETSMAISIS-LDKYCHPVALPKHKLVCDPELERPRTEMPNQLR----------KQ 573

  Fly   554 LKELMANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWYLLKQ- 617
            |:|::|.    |.::.:..:|:..:|..|::|::. ||....||..|.|.:::.||..:.||.:
 Frog   574 LEEIIAT----DPLHPLTPEDKELLWHFRSEIVKH-PEAYPKLLSSVKWGQQEMVAKTYQLLSKR 633

  Fly   618 --WPLISIE--RSLELLDYAYPDPAVRRFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLESDLVV 678
              |...|::  .:::|||..:.|..||..|::.|..|:|:|:|.||||||||:|.|.|.:|.|..
 Frog   634 EAWDDCSLDVGLTIQLLDCNFSDENVRAMAVQKLESLQDDDVLHYLLQLVQAVKFEPYHDSALSR 698

  Fly   679 FLLERALRNQRIGHYFFWHLRSEM-QTPSMQTRFGLLLEVYLKGC-KHHVAPLRKQLHVLEKLKQ 741
            |||:|||:::||||:.||.||||: |:...|.||.::||.||:|| |..:....:|:.|.|.|.:
 Frog   699 FLLKRALQSKRIGHFLFWFLRSEIAQSMHYQQRFAVILEAYLRGCGKAMLDDFTRQVQVTEILHK 763

  Fly   742 GSLIAKKGSKEK------VKTMLQDFLRDQRNSAVFQNIQN----PLNPSFRCSGVTPDRCKVMD 796
            .::..|..|.||      |.|.|:..|...:||.:...:.:    |.:|..|...:..::||||.
 Frog   764 VTMEIKSVSAEKYDVTSQVITQLRQKLEKLQNSKLPDKLPDSFRVPYDPGLRAGSLVVEKCKVMA 828

  Fly   797 SKMRPLWVVFENADVNA---SDVHIIFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCI 858
            ||.:|||:.|:.:|..|   ..:.||||:|||||||||.||:||:|..:|:.:.:|..:..|.||
 Frog   829 SKKKPLWLEFKCSDTTALSNETIGIIFKHGDDLRQDMLILQILRIMGSIWEAESLDLCLLPYGCI 893

  Fly   859 SMEKSLGMIEVVRHAETIANIQKEKGMFSATSPFKKGSLLSWLKEHNKPADKLNKAINEFTLSCA 923
            |....:||||:|:.|.|||.||  :.....|..||...|..||||.....:|.:.|:..|..|||
 Frog   894 STGNKIGMIEIVKDATTIAQIQ--QSTVGNTGAFKDEVLSQWLKEKCPIEEKFSAAVERFVYSCA 956

  Fly   924 GYCVATYVLGVADRHSDNIMVKRNGQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKG 988
            ||||||:|||:.|||:|||||..:|.|||||||||||::|..||:.:||||||||.||:||:...
 Frog   957 GYCVATFVLGIGDRHNDNIMVTESGNLFHIDFGHILGNYKSFLGINKERVPFVLTPDFLYVMGTS 1021

  Fly   989 FNDRESKEFCHFQELCERAFLVLRKHGCLILSLFSMMISTGLPELSSEKDLDYLRETLVLDYTEE 1053
             ..:.|:.|..||::|.:|:|.||.|..|::.|||||:.||:|:|:|::|::|:|::|.:...||
 Frog  1022 -GKKTSQYFNKFQDVCVKAYLALRHHTNLMIILFSMMLMTGMPQLTSKEDIEYIRDSLTVGKNEE 1085

  Fly  1054 KAREHFRAKFSEALANSWKTSLNWASH 1080
            .|::||..:........|....||..|
 Frog  1086 SAKKHFLDQIEVCRDKGWTVQFNWFLH 1112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pi3K92E	NP_650902.1	PI3K_p85B	56..132	CDD:470589
		PI3K_rbd	200..307	CDD:197540	29/117 (25%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	48/190 (25%)
		PI3Ka_I	552..723	CDD:238444	72/177 (41%)
		PI3Kc_I	727..1084	CDD:270709	156/367 (43%)
pik3cg	XP_012814080.1	PIK3CG_ABD	15..208	CDD:466155	15/52 (29%)
		PI3K_rbd	221..328	CDD:413336	29/110 (26%)
		C2_PI3K_class_I_gamma	366..546	CDD:176044	49/201 (24%)
		PI3Ka_I	568..744	CDD:238444	73/190 (38%)
		PI3Kc_IB_gamma	748..1118	CDD:270627	156/368 (42%)