Protein Alignment Septin2 and SEPTIN14

DIOPT Version :10

• Sequence 1: NP_524417.1
• Gene: Septin2 / 42438
• FlyBaseID: FBgn0014029
• Length: 419
• Species: Drosophila melanogaster
• Sequence 2: NP_997249.2
• Gene: SEPTIN14 / 346288
• HGNCID: 33280
• Length: 432
• Species: Homo sapiens
• Alignment Length: 417
• Identity: 246/417 - (58%)
• Similarity: 320/417 - (76%)
• Gaps: 0/417 - (0%)

  Fly     3 VEVDFVDKKEVHLRTLKQSGHVGFDSLPDQLVNKSVQNGFVFNVMCIGETGLGKSTLMDTLFNTS 67
            :..|...:||.::|.|...||.||:.||:|||::|::.||.||::|:||||:|||||:||||||:
Human    12 IPADGDTQKENNIRCLTTIGHFGFECLPNQLVSRSIRQGFTFNILCVGETGIGKSTLIDTLFNTN 76

  Fly    68 FESTPSPHTLPSVKLKAHTYELQESNVRLKLTICDTVGYGDQINKDDSFKAVVDYIDAQFENYLQ 132
            .:...|.|...:|.|:..|||||||||:||||:.:||||||||:|:.|::.:|||||||||.|||
Human    77 LKDNKSSHFYSNVGLQIQTYELQESNVQLKLTVVETVGYGDQIDKEASYQPIVDYIDAQFEAYLQ 141

  Fly   133 EELKIKRSLVTCHDSRIHICLYFICPTGHGLKSLDLVCMKKLDSKVNIIPVIAKADTISKVELQR 197
            |||||||||...||||:|:|||||.||||.||||||:.||.|||||||||:|||||||||.:||.
Human   142 EELKIKRSLFEYHDSRVHVCLYFISPTGHSLKSLDLLTMKNLDSKVNIIPLIAKADTISKNDLQT 206

  Fly   198 FKAKIIQELNANGVHIYQFPTDDETVAETNTSMNSHIPFAVVGSTEFIKVGNKLIRARQYPWGTV 262
            ||.||:.||.:||:.|||.|||:||.|:.|:|::..:||||||||:.:|||.:::|.|.||||.:
Human   207 FKNKIMSELISNGIQIYQLPTDEETAAQANSSVSGLLPFAVVGSTDEVKVGKRMVRGRHYPWGVL 271

  Fly   263 QVENETHCDFVKLREMLIRTNMEDMREKTHTRHYELYRQKRLEQMGFSDVDSDNKPISFQQTFEA 327
            |||||.||||||||:||:.||||:::|||||:|||.||.::|::|||:||..:|:|:|||:.|||
Human   272 QVENENHCDFVKLRDMLLCTNMENLKEKTHTQHYECYRYQKLQKMGFTDVGPNNQPVSFQEIFEA 336

  Fly   328 KRSNHLAELQSKEEEVRQMFVQRVKEKEAELKESEKDLHAKFEKLKRDHAEEKRKLEESRKALEE 392
            ||.....:.|.:|||::|.|:||||||||..||:||:|..|||.||....||.|||||.:|.||.
Human   337 KRQEFYDQCQREEEELKQRFMQRVKEKEATFKEAEKELQDKFEHLKMIQQEEIRKLEEEKKQLEG 401

  Fly   393 DYLDFQRRKQQLATAHHTLTLGKSKKK 419
            :.:||.:.|.........|:....|.|
Human   402 EIIDFYKMKAASEALQTQLSTDTKKDK 428

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Septin2	NP_524417.1	CDC_Septin	40..308	CDD:206649	176/267 (66%)
		PTZ00121	<285..393	CDD:173412	61/107 (57%)
SEPTIN14	NP_997249.2	CDC_Septin	49..317	CDD:206649	176/267 (66%)
		G1 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	59..66		5/6 (83%)
		G3 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	111..114		1/2 (50%)
		G4 motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU01056	194..197		2/2 (100%)
		PRK12704	335..>432	CDD:237177	44/94 (47%)
		Required for interaction with SEPTIN4. Required for migration of cortical neurons during corticogenesis. /evidence=ECO:0000250|UniProtKB:Q9DA97	369..432		25/60 (42%)