Protein Alignment Stat92E and Stat1

DIOPT Version :10

• Sequence 1: NP_001262760.1
• Gene: Stat92E / 42428
• FlyBaseID: FBgn0016917
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: NP_116001.2
• Gene: Stat1 / 25124
• RGDID: 3771
• Length: 749
• Species: Rattus norvegicus
• Alignment Length: 857
• Identity: 212/857 - (24%)
• Similarity: 354/857 - (41%)
• Gaps: 196/857 - (22%)

  Fly     1 MSLWKRISSHVDCE--QRMAAYYEEKGMLELRLCLAPWIEDR-------------IMSEQITPNT 50
            ||.|..: ..:|.:  :::...|::...:|:|..||.|:|.:             |....:....
  Rat     1 MSQWYEL-QQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAAYDVSFATIRFHDLLSQL 64

  Fly    51 TDQLERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVT 115
            .||..|.:|:.|..||..:..::.......:...|::..:|...                  |..
  Rat    65 DDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPVQMSMIIHNC------------------LKE 111

  Fly   116 EKSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQGIGPIHNVQNTGIASPA 180
            |:.:...|.:.......|:.||     .|:|....|.             ..:.||
  Rat   112 ERKILENAQRFNQAQEGNIQNT-----VMLDKQKELD-------------SKVRNV--------- 149

  Fly   181 LGMVTPKVELYEVQHQIMQSLNEFGNCANALKLLAQNYSYMLNSTSSPNAEAAYRSLIDEKAAIV 245
                  |.::..::|:|           ..|:.|...|.:...::.:..:||...:..|:|...:
  Rat   150 ------KDQVMCIEHEI-----------KTLEDLQDEYDFKCKTSQNRESEANGVAKSDQKQEQL 197

  Fly   246 LTMRRSFMYYESLHEMVIH-------------------ELKNWRHQQAQAGNGAPFNEGSLDDIQ 291
            | :.:.|:..::..:.:||                   ||..|:.:|..|..|.|.| ..||.:|
  Rat   198 L-LHKMFLMLDNKRKEIIHKIRELLNSIELTQNTLINDELVEWKRRQQSACIGGPPN-ACLDQLQ 260

  Fly   292 RCFEMLESFIAHMLAAVKELMRVRLVTEEPELTHLLEQ---VQNAQ----------KNLVCSAFI 343
            ..|.::...:..:...:|:|       ||.|.....||   .:|.|          :.|:.|:|:
  Rat   261 SWFTIVAESLQQVRQQLKKL-------EELEQKFTYEQDPITKNKQVLSDRTFVLFQQLIQSSFV 318

  Fly   344 VDKQP--------PQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMD 400
            |::||        |.|:||..:|...:|.|:..|...:|        :..::...:.|.     :
  Rat   319 VERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYN--------LKVKVSFDKDVN-----E 370

  Fly   401 NSSLSGQSSGEIQNASS---TMEYQQNNHVFSASFRNMQLKKIKRAEKKGTES---VMDEKFALF 459
            .:::.|.....|....:   .|| :..|...:|.||::|||:.|.|..:..|.   |.:|..:|.
  Rat   371 KNTVKGFRKFNILGTHTKVMNME-ESTNGSLAAEFRHLQLKEQKNAGNRTNEGPLIVTEELHSLS 434

  Fly   460 FYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDP-----FMITDRVTWA 519
            |.|........|.:.|.|||||||.:.:|.|..||:|.|.|.   :|.:|     |:......|:
  Rat   435 FETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNM---LVTEPRNLSFFLNPPCAWWS 496

  Fly   520 QLSVALNIKFGSCTGRSLTIDNLDFLYEKLQREERSE--YITWNQFCKEPMPDRSFTFWEWFFAI 582
            |||..|:.:|.|.|.|.|..|.|..|.|||.......  .|.|.:||||.:.|::|:||.|...|
  Rat   497 QLSEVLSWQFSSVTKRGLNADQLSMLGEKLLGPNAGPDGLIPWTRFCKENINDKNFSFWPWIDTI 561

  Fly   583 MKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSEL-GGVTIAYV--NENG- 643
            ::|.|.|:|.:|..|||||||:|.:.:. ||:.... ||||||||:|.. |.:|..:|  ::||
  Rat   562 LELIKKHLLCLWNDGCIMGFISKERERA-LLKDQQP-GTFLLRFSESSREGAITFTWVERSQNGG 624

  Fly   644 --LVTMLAPWTARDFQVLNLADRIRDLDVLC----------WLHPSDRNASPVKRDVAFGEFYSK 696
              ....:.|:|.::...:...|.||:..|:.          :|:|:      :.:|.|||::||:
  Rat   625 EPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPN------IDKDHAFGKYYSR 683

  Fly   697 RQE-PEPLVLDPV--TGYVKSTLHVHVCRNGENGSTSGTPHHAQESMQLGNISPQSGITFYSPAR 758
            .:| |||:.||..  |||:|:.|            .|.:..|........|:.|.|...|...::
  Rat   684 PKEAPEPMELDDPKRTGYIKTEL------------ISVSEVHPSRLQSTENLLPMSPEEFDEMSK 736

  Fly   759 LEESDSDASETA 770
            :..|:.|:..:|
  Rat   737 IVGSEFDSMMSA 748

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	22/131 (17%)
		STAT_CCD	191..338	CDD:341075	34/178 (19%)
		STAT_DBD	342..502	CDD:341082	49/173 (28%)
		SH2_STAT_family	578..696	CDD:198175	44/133 (33%)
Stat1	NP_116001.2	STAT_int	2..121	CDD:214942	23/137 (17%)
		STAT1_CCD	138..313	CDD:341076	38/222 (17%)
		STAT1_DBD	317..477	CDD:341083	49/176 (28%)
		SH2_STAT1	557..707	CDD:198235	56/169 (33%)
		STAT1_TAZ2bind	715..739	CDD:432372	4/23 (17%)