Protein Alignment Stat92E and stat3

DIOPT Version :10

• Sequence 1: NP_001262760.1
• Gene: Stat92E / 42428
• FlyBaseID: FBgn0016917
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: XP_031750540.1
• Gene: stat3 / 100498278
• XenbaseID: XB-GENE-481047
• Length: 769
• Species: Xenopus tropicalis
• Alignment Length: 872
• Identity: 203/872 - (23%)
• Similarity: 350/872 - (40%)
• Gaps: 210/872 - (24%)

  Fly     1 MSLWKRISSHVDCE--QRMAAYYEEKGMLELRLCLAPWIEDR-------------IMSEQITPNT 50
            |:.|.:: ..:|..  :::...|.:...:|||..||||||.:             ::...:....
 Frog     1 MAQWNQL-QQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAFAASKESHATLVFHNLLGEI 64

  Fly    51 TDQLERVALKFNEDLQQKLLSTRTASDQALKFRVVELCALIQRISAVELYTHLRSGLQKELQLVT 115
            ..|..|...:.|...|..|...:    |.|:.|.:|....|.||.|..|:        :|.:|:.
 Frog    65 DQQYSRFLQESNVLYQHNLRRIK----QFLQSRYLEKPMEIARIVARCLW--------EEGRLLQ 117

  Fly   116 EKSVAATAG--QSMPLNPYNMNNTPMVTGYMVD----PSDLLAVSNSCNPPVVQGIGPIHNVQNT 174
            ..:.||..|  .|.|..........|:..::.|    ..||           .|.:..:.|:|:.
 Frog   118 TAAAAAQQGGPASHPTAAVVTEKQQMLEQHLQDVRKKVQDL-----------EQKMKVVENLQDD 171

  Fly   175 GIASPALGMVTPKVELYEVQHQIMQSLNEF----GNCANALKLLAQNYSYMLNSTSSPNAEAAYR 235
                            ::..::.::|.::.    |:..:..:...|....||.:     .:...|
 Frog   172 ----------------FDFNYKTLKSQSDLSELNGSNQSVTRQKMQQLEQMLTA-----LDQLRR 215

  Fly   236 SLIDEKAAIVLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSLDDIQRCFEMLESF 300
            ::|.:.|:::..|.    |.:.  .:...||.:|:.:|..|..|.|.|        .|.:.||::
 Frog   216 TIISDLASLLSAME----YVQK--TLTDEELADWKRRQQIACIGGPPN--------ICLDRLENW 266

  Fly   301 IAHM----------LAAVKELMRVRLVTEEPELTH---LLEQVQNAQKNLVCSAFIVDKQP---- 348
            |..:          :..::||.:......:|.:.|   |.|::....:||:.|||:|::||
 Frog   267 ITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPM 331

  Fly   349 ----PQVMKTNTRFAASVRWLIGSQLGIHNNPPTVECIIMSEIQSQRFVTRNTQMDNSSLSGQSS 409
                |.|:||..:|...||.|:                        :|...|.|:.......:.|
 Frog   332 HPDRPLVIKTGVQFTTKVRLLV------------------------KFPELNYQLKIKVCIDKDS 372

  Fly   410 GEIQNASSTMEY-------------QQNNHVFSASFRNMQLKKIK-----RAEKKGTESVMDEKF 456
            |::.....:.::             :.||...||.|:::.|::.:     ||....:..|.:|..
 Frog   373 GDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELH 437

  Fly   457 ALFFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRV--TWA 519
            .:.|.|.......:|.:.|.|||||||.:..|.|.:||:|.|.|......::....|...  ||.
 Frog   438 LITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWD 502

  Fly   520 QLSVALNIKFGSCTGRSLTIDNLDFLYEKL----------QREERSEYITWNQFCKEPMPDRSFT 574
            |::..|:.:|.|.|.|.|:|:.|..|.|||          |       |||.:||||.|..:.|:
 Frog   503 QVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQ-------ITWAKFCKENMAGKGFS 560

  Fly   575 FWEWFFAIMKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSD-SELGGVTIAY 638
            ||.|...|:.|.|.::|.:|..|.|||||:|.:.:..|  |....||||||||: |:.||:|..:
 Frog   561 FWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAIL--STKPPGTFLLRFSESSKEGGITFTW 623

  Fly   639 VNEN----GLVTMLAPWTARDFQVLNLAD-----RIRD-----LDVLCWLHPSDRNASPVKRDVA 689
            |.::    ..:..:.|:|.:....::.|:     :|.|     :..|.:|:|.      :.::.|
 Frog   624 VEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPD------IPKEEA 682

  Fly   690 FGEF----YSKRQEPEPLVLDP--VTGYVKSTLHVHVCRNGENGSTS----GTPHHAQESMQLGN 744
            ||::    ..:.|||    .||  ...|:|:..   :|......|::    .:|......||.
 Frog   683 FGKYCRPESQEHQEP----TDPGSTAPYLKTKF---ICVTPTTCSSTLDLPMSPRTLDSLMQF-- 738

  Fly   745 ISPQSGITFYSPARLEESDSDASETAE 771
              |..|:...:..:.|....|...|:|
 Frog   739 --PGEGVESSAGNQFETLTFDMELTSE 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	28/131 (21%)
		STAT_CCD	191..338	CDD:341075	29/163 (18%)
		STAT_DBD	342..502	CDD:341082	45/185 (24%)
		SH2_STAT_family	578..696	CDD:198175	39/136 (29%)
stat3	XP_031750540.1	STAT_int	2..118	CDD:214942	28/128 (22%)
		STAT3_CCD	139..318	CDD:341078	37/224 (17%)
		STAT3_DBD	321..484	CDD:341085	45/186 (24%)
		SH2_STAT3	554..716	CDD:198237	51/176 (29%)