Protein Alignment Stat92E and stat4

DIOPT Version :10

• Sequence 1: NP_001262760.1
• Gene: Stat92E / 42428
• FlyBaseID: FBgn0016917
• Length: 818
• Species: Drosophila melanogaster
• Sequence 2: XP_031749081.1
• Gene: stat4 / 100496013
• XenbaseID: XB-GENE-478992
• Length: 761
• Species: Xenopus tropicalis
• Alignment Length: 870
• Identity: 219/870 - (25%)
• Similarity: 366/870 - (42%)
• Gaps: 200/870 - (22%)

  Fly     1 MSLWKRISSHVDCEQR----MAAYYEEKGMLELRLCLAPWIEDR-------------IMSEQITP 48
            ||.|.::..   .|||    :..:|::...:|:|..||.|||.:             ::...:..
 Frog     1 MSQWNQVQR---LEQRFLEQVDQFYDDTFPMEVRHLLASWIEGQDWDAASNSDSLATVLLHNLMI 62

  Fly    49 NTTDQLERVALKFN-------EDLQQKLLSTRTASDQALKFRVVELCALIQR--ISAVEL----- 99
            ...::|.||:.:.|       :.::|.||.....:...:.. :|..|...:|  ::|..:
 Frog    63 QIEEELNRVSQEKNLLLRHNLKRIKQHLLGKYHGNPMHMAM-IVSNCLREERRILAAASMPIQGP 126

  Fly   100 -YTHLRSGLQKELQLVTEKSVAATAGQSMPLNPYNMNNTPMVTGYMVDPSDLLAVSNSCNPPVVQ 163
             ...|::.|..|.|.|.|..|||            :.|:..||                    .|
 Frog   127 FEKSLQTNLISERQRVLENKVAA------------IKNSAQVT--------------------EQ 159

  Fly   164 GIGPIHNVQNTGIASPALGMVTPKVELYEVQHQIMQSLNEFGNCANALKLLAQNYSY----MLNS 224
            .:..:.::|:.                ::.:.:.:||    .:..:...:|.:...|    |||:
 Frog   160 DVKYLEDLQDE----------------FDFRFKTIQS----KDTTDKHNILIEQECYKLQEMLNA 204

  Fly   225 TSSPNAEAAYR--SLIDEKAAIVLTMRRSFMYYESLHEMVIHELKNWRHQQAQAGNGAPFNEGSL 287
            ......||..:  .:|||   |...|.:|          :..|||||:.:|..|..|.|.: |||
 Frog   205 LDQKRKEALRKMSQIIDE---IDTLMGKS----------LTEELKNWKRRQQIACIGGPLH-GSL 255

  Fly   288 DDIQRCFEMLESFIAHMLAAVKELMRV-RLVTEEPELTHLLEQVQNAQKNLVC-------SAFIV 344
            |.||..|.:|...:..:...:::|..: ..||.|.:...|  |.|.....::|       |:|||
 Frog   256 DQIQNWFTLLAESLFQLRRQIQKLDELWTKVTYEGDPIPL--QKQYLLDRVICLILSVFQSSFIV 318

  Fly   345 DKQP--------PQVMKTNTRFAASVRWLI-----GSQLGIHNNPPTVECIIMSEIQSQRFVTRN 396
            ::||        |.|:||..:|...:|.|:     ..||.:   ..|::......:.::|||...
 Frog   319 ERQPCMPTHPQRPLVLKTEIQFTVKLRLLVKLPELNYQLRV---KATIDKDPSFNLSNRRFVLFG 380

  Fly   397 TQMDNSSLSGQSSGEIQNASSTMEYQQNNHVFSASFRNMQLKKIK-RAEKKGTES---VMDEKFA 457
            |.:...|:...::|.:                |...|:::.|:.| .:..||.|.   |.:|..:
 Frog   381 TPVKVMSIEDSANGSL----------------SVEMRHLKPKESKSNSGNKGHEGVHMVTEELHS 429

  Fly   458 LFFYTTTTVNDFQIRVWTLSLPVVVIVHGNQEPQSWATITWDNAFAEIVRDPFMITDRVTWA--Q 520
            :.|.|...:....|.:.|.|||||:|.:.:|.|.:||::.|.|.|:...::.....:..|.:  |
 Frog   430 ISFETQVCLYGLAIDLETSSLPVVMISNVSQLPSAWASVIWYNLFSSEPQNHAFFANPPTASLNQ 494

  Fly   521 LSVALNIKFGSCTGRSLTIDNLDFLYEKL---QREERSEYITWNQFCKEPMPDRSFTFWEWFFAI 582
            |...|:.:|.|..||.|..:.|:.|.:||   ...:...:|:|.:||||.:|.:.|:||.|...|
 Frog   495 LLEVLSWQFSSYVGRGLNSEQLNMLGDKLIGVPVNQGDNHISWVKFCKEHLPGKPFSFWAWIEGI 559

  Fly   583 MKLTKDHMLGMWKAGCIMGFINKTKAQTDLLRSVYGIGTFLLRFSDSELGGVTIAYV--NENGLV 645
            ::|.|.::|.:|..||||||::|.|.:..|...:  .||||||||:|.||.:|..:|  ::.|.|
 Frog   560 LELIKKYLLSIWIDGCIMGFVSKEKERALLKDKI--PGTFLLRFSESHLGSITFTWVDLSDTGEV 622

  Fly   646 TM--LAPWTARDFQVLNLADRIRDLDV----------LCWLHPSDRNASPVKRDVAFGEFYSKRQ 698
            ..  :.|:.......|...|.:|...|          |.:|:|.      |.:|.|||:.|:..|
 Frog   623 RFHSVEPYNKGRLNALPFPDILRTYKVIEAENAPENPLLYLYPD------VPKDKAFGKHYNSHQ 681

  Fly   699 EPEPLVLDPVTGYVKSTLHVHVCRNGENGSTSGTPHHAQESMQLGNISPQSGITFYSPARLEESD 763
            .......:.|.|||.| :.:.:.:...|||:|.:|      |.|    |.|...|   |.|.|..
 Frog   682 NEVSQPTENVKGYVPS-VFIPMSKLPTNGSSSPSP------MDL----PMSPSIF---AALREQL 732

  Fly   764 SDASETAEALERIVIGAQPNDPVIS 788
            :......:||.:.|     |.||::
 Frog   733 TYTEIENDALPKTV-----NRPVVA 752

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Stat92E	NP_001262760.1	STAT_int	2..119	CDD:214942	30/148 (20%)
		STAT_CCD	191..338	CDD:341075	39/153 (25%)
		STAT_DBD	342..502	CDD:341082	46/176 (26%)
		SH2_STAT_family	578..696	CDD:198175	44/131 (34%)
stat4	XP_031749081.1	STAT_int	2..121	CDD:214942	24/122 (20%)
		STAT4_CCD	140..312	CDD:341079	51/239 (21%)
		STAT_DBD	316..473	CDD:355796	45/175 (26%)
		SH2_STAT4	555..702	CDD:198238	50/155 (32%)