DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4360 and ZNF48

DIOPT Version :9

Sequence 1:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster
Sequence 2:	NP_001201835.1	Gene:	ZNF48 / 197407	HGNCID:	13114	Length:	618	Species:	Homo sapiens

Alignment Length:	512	Identity:	133/512 - (25%)
Similarity:	187/512 - (36%)	Gaps:	159/512 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   144 CHVCKNKFRQLTTLRNHMKIHTDERPYKC--------------KH-------------------- 174
            |..|...|||::.|..|.:.||.|:||||              ||
Human   114 CGECGKSFRQMSDLVKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQRTHSGEKPYRARPPAQGPP 178

  Fly   175 ------------------CDKAFRQISTLTNHVKIHTGEKPFTCNICAKDFRQQSTLINHIKTHK 221
                              |.|:|||.|.|..|.:.||||||:.|.||.|.|...|..|.|.:||:
Human   179 KIPRSRIPAGERPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCGICGKGFGDSSARIKHQRTHR 243

  Fly   222 AAESSTPTSLLNYQPQTGSGKHRKSQMHQAYQQQHQRVQISKTLYSGSYSSPAAEELVKPFQCSV 286
            ..:...|.                     ..::|..|...:.|      ..|.|::  ||:.|:.
Human   244 GEQPPRPV---------------------VPRRQPSRAATAAT------QGPKAQD--KPYICTD 279

  Fly   287 CKRRFPQLSTLHNHERTHIDPKPYKCETCDKSFSQLATLANHKKIHTGDKPYTCSYCHMQFRQQS 351
            |.:||....:|.:|:|:|:.|||:.|:.|.|.|::.:.|..|.::|||:|||.|..|...|...|
Human   280 CGKRFVLSCSLLSHQRSHLGPKPFGCDVCGKEFARGSDLVKHLRVHTGEKPYLCPECGKGFADSS 344

  Fly   352 TLTNHLKTHTHQIAPGGVGGAGGGGGAVTATVDHSMPAPLAPGTQQLTSGLLPNNLHGSTANIIQ 416
            ....||:||:.: .|                  |:.|.  ...|..|:|.||.:.|.........
Human   345 ARVKHLRTHSGE-RP------------------HACPE--CDRTFSLSSTLLRHRLTHMEPQDFS 388

  Fly   417 LDHHPLLHFLDGSTT----VSSVVATAAANTKVEHFQAGG---SPSGRMTVVGTINMLKGDNP-- 472
            ...:||...:.....    .|..:...:.:...|.|...|   .|.|...         |:.|
Human   389 FPGYPLPALIPSPPPPPLGTSPPLTPRSPSHSGEPFGLPGLEPEPGGPQA---------GEPPPP 444

  Fly   473 ---DRPFGCSVCQRFFSQQSTLVNHIKTHTGEKPYKCKICEVNFRQVATLNNHMKIHTGEK---- 530
               |:|..|..|.:.|.:.|.||.|.:.|||||||.|..|...|...:....|::.|.||:
Human   445 LAGDKPHKCPECGKGFRRSSDLVKHHRVHTGEKPYLCPECGKGFADSSARVKHLRTHRGERARPP 509

  Fly   531 --------------------------------PYNCSFCPKQFRQKSTLQNHLRVHT 555
                                            |:.|.||.|:|.:.|.|..|.|.||
Human   510 PPSTLLRPHNPPGPVPMAPRPRVRAQPSGPSQPHVCGFCGKEFPRSSDLVKHRRTHT 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	7/19 (37%)
		zf-H2C2_2	157..181	CDD:290200	14/75 (19%)
		C2H2 Zn finger	172..192	CDD:275368	11/71 (15%)
		zf-H2C2_2	185..209	CDD:290200	13/23 (57%)
		C2H2 Zn finger	200..220	CDD:275368	8/19 (42%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-C2H2_8	287..363	CDD:292531	30/75 (40%)
		C2H2 Zn finger	312..332	CDD:275368	6/19 (32%)
		C2H2 Zn finger	340..360	CDD:275368	6/19 (32%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	491..515	CDD:290200	13/23 (57%)
		C2H2 Zn finger	506..526	CDD:275368	4/19 (21%)
		zf-H2C2_2	519..543	CDD:290200	10/59 (17%)
		C2H2 Zn finger	534..554	CDD:275368	9/19 (47%)
ZNF48	NP_001201835.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..109
		zf-C2H2	113..134	CDD:278523	7/19 (37%)
		COG5048	114..499	CDD:227381	118/443 (27%)
		C2H2 Zn finger	114..134	CDD:275368	7/19 (37%)
		zf-H2C2_2	126..149	CDD:290200	9/22 (41%)
		C2H2 Zn finger	142..162	CDD:275368	3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..189		2/31 (6%)
		C2H2 Zn finger	194..214	CDD:275368	8/19 (42%)
		zf-C2H2	194..214	CDD:278523	8/19 (42%)
		zf-H2C2_2	206..229	CDD:290200	12/22 (55%)
		C2H2 Zn finger	222..242	CDD:275368	8/19 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..271		9/62 (15%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..325	CDD:275368	6/19 (32%)
		zf-H2C2_2	317..341	CDD:290200	10/23 (43%)
		C2H2 Zn finger	333..353	CDD:275368	6/19 (32%)
		zf-H2C2_2	348..369	CDD:290200	8/41 (20%)
		C2H2 Zn finger	361..381	CDD:275368	7/21 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..457		13/73 (18%)
		zf-C2H2	451..473	CDD:278523	7/21 (33%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..489	CDD:290200	12/23 (52%)
		C2H2 Zn finger	481..501	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..540		3/39 (8%)
		COG5048	524..>591	CDD:227381	12/43 (28%)
		zf-C2H2	543..565	CDD:278523	9/21 (43%)
		C2H2 Zn finger	545..565	CDD:275368	9/19 (47%)
		zf-H2C2_2	557..580	CDD:290200	5/10 (50%)
		C2H2 Zn finger	573..593	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3714
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950