Protein Alignment Orp8 and KES1

DIOPT Version :10

• Sequence 1: NP_001189250.2
• Gene: Orp8 / 42412
• FlyBaseID: FBgn0261550
• Length: 990
• Species: Drosophila melanogaster
• Sequence 2: NP_015180.1
• Gene: KES1 / 855958
• SGDID: S000006066
• Length: 434
• Species: Saccharomyces cerevisiae
• Alignment Length: 344
• Identity: 105/344 - (30%)
• Similarity: 155/344 - (45%)
• Gaps: 61/344 - (17%)

  Fly   483 DLSKVVLPTFILEPRS--------------FLDK--LSDSYYHADLLSKAVQEDDAFTRMKLVVQ 531
            |||.:..|.|||.|.|              ||:.  ::|..|....|.....|.....||..|.:
Yeast    23 DLSSLSAPPFILSPISLTEFSQYWAEHPELFLEPSFINDDNYKEHCLIDPEVESPELARMLAVTK 87

  Fly   532 WYLSS----FYKKPKGL---KKPYNPILGERFRCYW---QHPSGSRTFYIAEQVSHHPPVSAFYV 586
            |::|:    :..:.:.|   |||.||.|||.|...|   :||....|..::|||||||||:||.:
Yeast    88 WFISTLKSQYCSRNESLGSEKKPLNPFLGELFVGKWENKEHPEFGETVLLSEQVSHHPPVTAFSI 152

  Fly   587 TNRED-----GF-----SITCSILAKSKFYGNSTSAVLEGAATMTLLP-RGECYTATTPYAHCKG 640
            .|.::     |:     |.|.|::...|.:|:            |:|. :.|.|..|.|..|.:|
Yeast   153 FNDKNKVKLQGYNQIKASFTKSLMLTVKQFGH------------TMLDIKDESYLVTPPPLHIEG 205

  Fly   641 ILMGTLSMELGGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKI-------KLGKETLATI 698
            ||:.:..:||.||..|: .:||....:||..:.:..|  ..|....:|       |..::.|.||
Yeast   206 ILVASPFVELEGKSYIQ-SSTGLLCVIEFSGRGYFSG--KKNSFKARIYKDSKDSKDKEKALYTI 267

  Fly   699 NGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIANEDQV 763
            :|.|....::..:...||:.||...|...::.|.  :.||:.|...||::.|..|:.||...|..
Yeast   268 SGQWSGSSKIIKANKKEESRLFYDAARIPAEHLN--VKPLEEQHPLESRKAWYDVAGAIKLGDFN 330

  Fly   764 AATEEKTVLEERQRADAKE 782
            ...:.||.|||.||...||
Yeast   331 LIAKTKTELEETQRELRKE 349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orp8	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103
		Oxysterol_BP	471..817	CDD:460126	105/344 (31%)
KES1	NP_015180.1	Oxysterol_BP	12..363	CDD:460126	105/344 (31%)