Protein Alignment Orp8 and Osbpl5

DIOPT Version :10

• Sequence 1: NP_001189250.2
• Gene: Orp8 / 42412
• FlyBaseID: FBgn0261550
• Length: 990
• Species: Drosophila melanogaster
• Sequence 2: NP_001015024.2
• Gene: Osbpl5 / 361686
• RGDID: 1308402
• Length: 898
• Species: Rattus norvegicus
• Alignment Length: 870
• Identity: 391/870 - (44%)
• Similarity: 532/870 - (61%)
• Gaps: 84/870 - (9%)

  Fly   165 PSTDSLSNSPA------PSSPGIANWA--SDNRDGNVADKS-AADAAKLNRKESYKAQRKNYRRE 220
            |..|..||.|:      |.:||.|...  ::.|..|.:||. .:...::::|::.|||::|||:|
  Rat    69 PGRDMESNGPSQPRDEEPLTPGSATKVPLAEYRLCNGSDKECTSPTTRVSKKDTLKAQKENYRQE 133

  Fly   221 KKRVASELMNSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSSHWVGTVMLT 285
            |||...:|.::|.||:|:::||.||:|||||||||||||||||:|||||:.|.  ..|||||:|.
  Rat   134 KKRATKQLFSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKV--GQWVGTVLLH 196

  Fly   286 SCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDA 350
            .|::||||||||||||||||||:||:||.:||..||:|::.||||::||||||.|::.|:||:||
  Rat   197 CCELIERPSKKDGFCFKLFHPLDQSVWAVKGPKGETVGSITQPLPSSYLIFRAASESDGRCWLDA 261

  Fly   351 LELSLRCSALLLRS----------NSSTGTAPTSSYIGEP----------LPVSHETQWSEA--D 393
            |||:||||:||..|          .||...:|:|.| |.|          .|::.....::|  |
  Rat   262 LELALRCSSLLRLSTCKQGRDGEQGSSPDASPSSLY-GLPTSATIPDQDLFPLNGSALENDAFSD 325

  Fly   394 YEKHFNDHDLDADSQNEAPNAVMSGLESESESDPAEPAQDDVVDQQCVETSYVPFTEEEFGEQGE 458
            ..:..|..|.||::|:.:.....||  |:....|..|.:.         |:||...:||.||..|
  Rat   326 KSERENADDSDAETQDHSRKTNESG--SDLLDSPGGPRRG---------TTYVEQVQEELGELDE 379

  Fly   459 --QVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDD 521
              |||.::||||||:|.:::|:|||||||:||||||:|||||||.||||.|||.||||:|..|||
  Rat   380 TSQVETVSEENKSLMWVLLRQLRPGMDLSRVVLPTFVLEPRSFLSKLSDYYYHGDLLSRAAAEDD 444

  Fly   522 AFTRMKLVVQWYLSSFYKKPKGLKKPYNPILGERFRCYWQHP-SGSRTFYIAEQVSHHPPVSAFY 585
            .:.|:|||::||||.|||||||:||||||||||.|||.|.|| :.|.||||||||||||||||||
  Rat   445 PYCRIKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWLHPQTNSHTFYIAEQVSHHPPVSAFY 509

  Fly   586 VTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGECYTATTPYAHCKGILMGTLSMEL 650
            |:||:|||.::.||.|||||||||.||:|:|.|.:|.|.|.|.||.|.|||||:|:|.||::|||
  Rat   510 VSNRKDGFCMSGSITAKSKFYGNSLSALLDGKAKLTFLNRKEEYTLTMPYAHCRGLLYGTMTMEL 574

  Fly   651 GGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGE 715
            |||:.|:||....:.||:||||||.|.:.:.|.:.|||..|:|.||.:.||||::..:|:..:|.
  Rat   575 GGKVTIQCEKNNLQAELDFKLKPFFGSSTSINQISGKITSGEEVLARLTGHWDRDVFIKEEASGG 639

  Fly   716 ETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADA 780
            ..:.:....|.|.:||.|:.|.|:.|...||:||||.|:.||...||..||:||:||||.||..|
  Rat   640 TKLFWTPSEEVRRQRLKRHTVLLEEQSELESERLWQHVTRAIHEGDQHKATQEKSVLEEAQRQRA 704

  Fly   781 KERLSSDSVHMPDLFELDSYGQ-WLYKYADLRPWDSRNDVRQYECQFKVL----TQTRHKSVPIV 840
            :|...|.:...|.||.||...| |.|:|.|..|||...|:.||| |..:|    .:|.......:
  Rat   705 REHQQSLTPWKPQLFTLDPLTQEWRYQYEDYSPWDPLKDIAQYE-QDGILHTLQRETMSGQTAFL 768

  Fly   841 HGAEMIHPLRSSIETLSRTQRQSPAGQPLPPGGSAVPKAKNKSLVLAPRDTNSD---SSQSPQGA 902
            ...|..|...||...|.:...|       |.|.|.|.::...:....|..::.|   .::||...
  Rat   769 GSPESRHKRPSSDRRLRKASDQ-------PSGHSQVTESSGSTPESCPDLSDEDFVPGNESPCPR 826

  Fly   903 VKRS--SSSAIKQLALAVDQVNRVLEQHTRQLNEISQRLERMQYSPPPSSMSAHSLHMLGGGVSQ 965
            .:|.  ....:::..|::.:..:.|.:|   |:.:.:...|...:|.|             |:.|
  Rat   827 CRREVHRLRMLQEAVLSIQEAQQELHRH---LSAMLRSTVRAGQAPAP-------------GLLQ 875

  Fly   966 STVIKSLIYALIGLAFSLILRWLFK 990
            :.  :|.....|.|...|.:.::.|
  Rat   876 NP--RSWFLLCIFLTCQLFINYILK 898

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orp8	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	88/129 (68%)
		Oxysterol_BP	471..817	CDD:460126	202/347 (58%)
Osbpl5	NP_001015024.2	PH_OPR5_ORP8	144..272	CDD:270103	88/129 (68%)
		Oxysterol_BP	394..740	CDD:460126	201/345 (58%)