Protein Alignment Orp8 and Osbpl10

DIOPT Version :10

• Sequence 1: NP_001189250.2
• Gene: Orp8 / 42412
• FlyBaseID: FBgn0261550
• Length: 990
• Species: Drosophila melanogaster
• Sequence 2: NP_001414621.1
• Gene: Osbpl10 / 316039
• RGDID: 1561652
• Length: 766
• Species: Rattus norvegicus
• Alignment Length: 845
• Identity: 232/845 - (27%)
• Similarity: 340/845 - (40%)
• Gaps: 226/845 - (26%)

  Fly    94 SAGGGTGAGA---------VTPSGLSMGASNQSLGVSV----------GAASSVSGISITPPNSA 139
            ||.||.|.|:         .|.:|.|...|....||:.          |:.||...::.:|....
  Rat     7 SADGGGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVASRSGAAGLGGGGSRSSPGSVAASPSGGG 71

  Fly   140 GLRQSTVFDFKFKRRPSLKVLMTKLPSTDSLSNSPAPSSPGIANWASDNRDGNVADKSAADAAKL 204
            |.|          |.|:|:.:::|..:.             :..|  .|| ..|.|..|......
  Rat    72 GRR----------REPALEGVLSKYTNL-------------LQGW--QNR-YFVLDFEAGLLQYF 110

  Fly   205 NRKESYKAQRKNYRREKKRVASELMN---SLQD--PAVIVL----ADWLKVRGTLKSWTKLW--- 257
            ..::|        :.:|.|....|..   ||.|  |.::|:    .:..|:|.......:||
  Rat   111 VNEQS--------KHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMYKLRAADSREKQLWVTQ 167

  Fly   258 ---CV---------LKPG-----LLLIYK---------SQKTKSSHWVGTVMLT---SCQVIERP 293
               |.         ..||     |.|:..         ||:..|:...|.|.:|   |.....|
  Rat   168 LRACAKYHMETSSKTTPGSRSRSLTLLPHGTPSSASPCSQRHLSAGAPGVVSVTRHKSPAAARR- 231

  Fly   294 SKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDALELSLRCS 358
             .|..:..:| |.:.:.:....|..|..:.| ::.||             |...:.||:..|
  Rat   232 -AKSQYSGQL-HEVREMMNQVEGQQKNLVHA-IESLP-------------GSGPLTALDQDL--- 277

  Fly   359 ALLLRSNSSTGTAPTSSYIGEPL-----------PVSHETQWSEADYEKHFNDHDLDADSQNEAP 412
             |||::.|    |.|.|.:||.|           |.||:...||:    ....|...:.|.::..
  Rat   278 -LLLKATS----AATLSCLGECLTLLQQSVRQAGPPSHKPGASES----ILGWHGPTSQSTDQLK 333

  Fly   413 NAVMSGLES---------------ESESDPAEPAQDDVVDQQCVETSYVPFTEEE---FGEQGEQ 459
            |..:..|.|               |..|...||..|...:        :..:|||   ..::||.
  Rat   334 NGTLGSLPSASANITWAILPNSAEEEHSSQPEPEPDSGPE--------LVLSEEEQSDHEDKGEV 390

  Fly   460 VEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLL----SKAVQED 520
            .....|:..|:|..::.|::.||||:||||||||||.||.|:..:|...|.|||    :.|..|:
  Rat   391 EPGTVEDQHSVILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEE 455

  Fly   521 DAFTRMKLVVQWYLSSFYKKPKG--LKKPYNPILGERFRCYW---------------------QH 562
                |:...|::||::|::..||  .|||||||:||.|.|.|                     :|
  Rat   456 ----RVISFVEYYLTAFHEGRKGTLAKKPYNPIIGETFHCSWEVPKDRVKSKWTSPHPPISCHEH 516

  Fly   563 PSG---SRTF---YIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMT 621
            |..   |:::   ::|||||||||:|.||...:|....:...:..||||.|.|....:.|...:.
  Rat   517 PMADDPSKSYKLRFVAEQVSHHPPISCFYCECKEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLR 581

  Fly   622 LLPRGECYTATTPYAHCKGILMGTLS-MELGGKINIECENTGYRTELEFKLKPFLGGA------- 678
            ||..||.|..|.|.|:.:.||  |:. :|||||:||.|..|||...:.|..|||.||.
  Rat   582 LLDHGEEYVFTLPSAYARSIL--TVPWVELGGKVNISCAKTGYSATVTFHTKPFYGGKVHRVTAE 644

  Fly   679 ---DATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDL 740
               :.||.:|.|          .:|.|:.......| .||..|:.........|:|.    ||:.
  Rat   645 VKHNPTNTIVCK----------AHGEWNGTLEFTYS-NGETKVIDTTTLPVYPKKLR----PLEK 694

  Fly   741 QEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSYGQWLY 805
            |...||:.|||.|:..:...|..||||:|..|||:||.:.::|.:..:...|..|..:..| |:|
  Rat   695 QGPMESRNLWQEVTHYLRLGDIDAATEQKRRLEEKQRTEERKRETLRTPWRPKYFIPEGDG-WVY 758

  Fly   806  805
              Rat   759  758

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orp8	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	34/167 (20%)
		Oxysterol_BP	471..817	CDD:460126	134/379 (35%)
Osbpl10	NP_001414621.1	None