Protein Alignment Orp8 and Osbpl8

DIOPT Version :10

• Sequence 1: NP_001189250.2
• Gene: Orp8 / 42412
• FlyBaseID: FBgn0261550
• Length: 990
• Species: Drosophila melanogaster
• Sequence 2: NP_001296384.1
• Gene: Osbpl8 / 314824
• RGDID: 1561474
• Length: 888
• Species: Rattus norvegicus
• Alignment Length: 927
• Identity: 414/927 - (44%)
• Similarity: 573/927 - (61%)
• Gaps: 101/927 - (10%)

  Fly   111 MGASNQSLGVSVGAASSVSGISITPPNSAGLRQSTVFDFKFKR-RPSLKVLMTKLPST------- 167
            :|.|...||.|...|:|.....:||...:..:....:....:. :|||.      |::
  Rat    16 LGDSKDVLGPSTVVANSEEPQHLTPGKMSQRQGKDAYPTPTRELQPSLS------PASLHSQGFE 74

  Fly   168 ---DSLSNSPAPSSPGIANWASDNRDGNVADKSAADAAKLNRKESYKAQRKNYRREKKRVASELM 229
               :.:|.:...||..::...|:::..|.::|.::.::||.:|||.|.|:||||.||||...||:
  Rat    75 RGKEDISQNKDDSSLSMSKSKSESKLYNGSEKDSSTSSKLTKKESLKVQKKNYREEKKRATKELL 139

  Fly   230 NSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSSHWVGTVMLTSCQVIERPS 294
            :::.||:|||:|||||:|||||||||||||||||:|||||:|  |:..|||||:|.:|::|||||
  Rat   140 STITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKTQ--KNGQWVGTVLLNACEIIERPS 202

  Fly   295 KKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWMDALELSLRCSA 359
            |||||||||||||||||||.:||..|.:|::.||||::|||.||.|::.|:||||||||:|:||.
  Rat   203 KKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIRATSESDGRCWMDALELALKCSG 267

  Fly   360 LLLRSNSSTGTAPTSSYIGEPLPVSHET----------------QWSEADYEK-HFNDHDLDAD- 406
            ||.|:....|.....|...:.   :|.|                |.::::.|: ||.|.|:.:|
  Rat   268 LLKRTMMRDGKEHDLSISSDS---THVTLYGLLRANNLHSGDNFQLNDSEIERQHFKDQDMYSDK 329

  Fly   407 -------SQNEAPNAVMSGLESESESDPAEPAQDDVVDQQCV----ETSYVPFTEEEFGEQGE-- 458
                   ..:|:.|.|: |...||::|.:|...|..:|.:.|    ||:|:..:.||.||.||
  Rat   330 SDKENDQEHDESDNEVL-GKSEESDTDTSERQDDSYIDPEPVEPLKETTYMEQSHEELGEAGEAS 393

  Fly   459 QVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDDAF 523
            |.|.::||||||||.::||||||||||:|||||||||||||||||||.|||||.||:|..|::.:
  Rat   394 QTETVSEENKSLIWTLLKQVRPGMDLSRVVLPTFILEPRSFLDKLSDYYYHADFLSEAALEENPY 458

  Fly   524 TRMKLVVQWYLSSFYKKPKGLKKPYNPILGERFRCYWQHP-SGSRTFYIAEQVSHHPPVSAFYVT 587
            .|:|.||:||||.||||||||||||||||||.|||.|.|| :.|:|||||||||||||:|||||:
  Rat   459 FRLKRVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPRTNSKTFYIAEQVSHHPPISAFYVS 523

  Fly   588 NREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGECYTATTPYAHCKGILMGTLSMELGG 652
            ||:|||.::.||||||||||||.||:|||.|.:|.|.|||.|..|.|||||||||.||:::||||
  Rat   524 NRKDGFCLSGSILAKSKFYGNSLSAILEGEARLTFLNRGEDYVMTMPYAHCKGILYGTMTLELGG 588

  Fly   653 KINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEET 717
            .:||.|:.|||...||||||||||.:|..|.:.||:|||||.|||:.||||.|..:.|.||....
  Rat   589 TVNITCQKTGYSAILEFKLKPFLGSSDYVNQISGKLKLGKEVLATLEGHWDSEVFINDKKTDNSE 653

  Fly   718 VLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKE 782
            :.:....:.:..||.|:.|..:.|:..||::|||||::||..:||..||:||.||||.||..|::
  Rat   654 IFWNPTPDIKQWRLIRHTVKFEEQDDFESEKLWQRVTKAINAKDQTEATQEKYVLEEAQRQAARD 718

  Fly   783 RLSSDSVHMPDLFELDSY-GQWLYKYADLRPWDSRNDVRQYECQFKVLTQTRHKSVPIVHGAEMI 846
            |.:.:......|||||.. |:|.||::|.||||..||:.|:|....:.|:.:|:: |:|...:|.
  Rat   719 RKTKNEEWACKLFELDPLTGEWHYKFSDTRPWDPLNDMIQFEKDGVIQTKVKHRT-PMVSVPKMK 782

  Fly   847 H-PLRSSIETLSRTQRQSPAGQPLPPGGSAVPKAKNKSLVLAPRDTNSDSSQSPQGAVKRSSSSA 910
            | |        :|.|::...|...|.     |..         :|::...:||.:.:.:|.....
  Rat   783 HKP--------TRQQKKVAKGYSSPE-----PDV---------QDSSGSEAQSVKPSTRRKKGID 825

  Fly   911 IKQLALAVDQVNRVLEQHTRQLNEISQRLERMQYSPPPSSMSAHSLHMLGGGVSQSTVIKSLIYA 975
            :..:..:::.:.:..|:..|.:..:..                   |:|....:....::...|.
  Rat   826 LGDIQSSIESIKQTQEEIKRNIMALRN-------------------HLLSSTPATDYFLQQKDYF 871

  Fly   976 LIGLAFSL--ILRWLFK 990
            :|.|...|  |:.::||
  Rat   872 VIFLLILLQVIINFIFK 888

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orp8	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	91/129 (71%)
		Oxysterol_BP	471..817	CDD:460126	214/347 (62%)
Osbpl8	NP_001296384.1	PH_OPR5_ORP8	141..270	CDD:270103	92/130 (71%)
		Oxysterol_BP	406..752	CDD:460126	213/345 (62%)