Protein Alignment Orp8 and obr-4

DIOPT Version :10

• Sequence 1: NP_001189250.2
• Gene: Orp8 / 42412
• FlyBaseID: FBgn0261550
• Length: 990
• Species: Drosophila melanogaster
• Sequence 2: NP_491691.1
• Gene: obr-4 / 172253
• WormBaseID: WBGene00016331
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 700
• Identity: 210/700 - (30%)
• Similarity: 294/700 - (42%)
• Gaps: 172/700 - (24%)

  Fly   246 VRGTLKSWTKL-------WCVLKPGLLLIYKS-QKTKSSHWVGTVMLTSCQV-IERPSKK----- 296
            :.|.|..||.:       |..::...||.|.| :|.......|.:.||...| |:..:..
 Worm     1 MEGPLSKWTNMVHGWQYRWFKIENDTLLYYTSREKMLKGQQRGQIRLTGAVVGIDGENNSLFTIT 65

  Fly   297 -DGFCFKLFHP--------------LEQSIWAPRG------------------------------ 316
             :|   |.||.              ||.||.|..|
 Worm    66 VEG---KTFHMQGRDLRERNQWVRILENSIRASSGYAKNVSVGTTPSQHFKQRTEEANEFLKTLV 127

  Fly   317 ----------------PDKETIGAVVQPLPTA------YLIFRAPSQAAGKCWMDALELSLRCSA 359
                            .:|:||.:::......      .:|:...:||       .|:.:::...
 Worm   128 EKVKALEQLKSGERAVDEKKTIDSLIAASNNLTNNVKHAIIYLQMAQA-------RLDPNMKTEK 185

  Fly   360 LLL---------RSNSSTGTAPTSSYIGEPLPVS-----------HETQWSEADYEKHFNDHD-- 402
            |:.         .|..:.||...|:......|:|           ....::.:| |:.|.|.|
 Worm   186 LMFTHPDLNEKPSSRETPGTVSDSTQTSTDKPISGIQHLDHLKPQRAESYASSD-EEEFYDADEE 249

  Fly   403 -LDADSQNEAPNAVMSGLESESESDPAEPAQDDVVDQQCVETSYVPFTEEEFGEQGEQVEEL--- 463
             :|.|:.....:...|| :|...||.|..:.|        |..|      :||:..|..:|:
 Worm   250 LIDLDNFESEKSGQESG-DSNRTSDAAIMSSD--------EDGY------DFGDSNEDFDEIYNN 299

  Fly   464 AEENK---------SLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQE 519
            |||:.         |::..::.||..||||:||.|||||||.||.|:..:|.:.|.||.......
 Worm   300 AEEHDIGNVQQDHGSVLMHLLSQVSVGMDLTKVTLPTFILERRSLLEMYADFFAHPDLFIATNGN 364

  Fly   520 DDAFTRMKLVVQWYLSSFY--KKPKGLKKPYNPILGERFRCYWQHP----SGSRT---------- 568
            |.|..||..||::||:|||  :|....|||||.||||.|||.:..|    ||.:|
 Worm   365 DSAEKRMIAVVRYYLNSFYAARKSGVAKKPYNAILGETFRCRYSVPNSSLSGKKTESGPWPGSDE 429

  Fly   569 ---FYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRG-ECY 629
               .:||||||||||:||||.....:|.|....|..||.|.|.|......|...:||...| |.|
 Worm   430 KQLTFIAEQVSHHPPISAFYAEMPSEGISFNAHIYTKSSFLGLSIGVASIGEGILTLHNYGDEQY 494

  Fly   630 TATTPYAHCKGILMGTLSMELGGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKI--KLGK 692
            |.|.|..:.:.| |.|...|.|||:.:|||.||||.::||..|||.||  ..:.:.|.|  ...|
 Worm   495 TITFPSGYGRSI-MSTPWFEFGGKVKVECEKTGYRADIEFLTKPFFGG--KPHRIQGSICRDGAK 556

  Fly   693 ETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAI 757
            :.:.|:.|.|:.....| ::.|||.|...|.|:...|   :..||:..|...||:|||:.|:.|:
 Worm   557 KPVLTLRGEWNGTMYAK-TQNGEEYVFVDVKAKPEVK---KECVPVMQQGKRESRRLWRHVTAAL 617

  Fly   758 ANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFE-LDSYGQWLYK 806
            .......||..|..:|:|||.:|||||.|.....|.||: .|..|:|:||
 Worm   618 LRNRIQTATTSKRFIEQRQRKEAKERLESGEKWTPLLFDTTDKDGEWMYK 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orp8	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	32/195 (16%)
		Oxysterol_BP	471..817	CDD:460126	146/358 (41%)
obr-4	NP_491691.1	PH_ORP9	1..100	CDD:241444	25/101 (25%)
		Oxysterol_BP	318..669	CDD:460126	146/356 (41%)