Protein Alignment Orp8 and Orp8

DIOPT Version :10

• Sequence 1: NP_001189250.2
• Gene: Orp8 / 42412
• FlyBaseID: FBgn0261550
• Length: 990
• Species: Drosophila melanogaster
• Sequence 2: XP_061497346.1
• Gene: Orp8 / 1270948
• VectorBaseID: AGAMI1_013364
• Length: 1078
• Species: Anopheles gambiae
• Alignment Length: 1164
• Identity: 576/1164 - (49%)
• Similarity: 680/1164 - (58%)
• Gaps: 317/1164 - (27%)

  Fly    20 SAASGPAASAPAVASSTPIRINSAKQQGAAGGGDTLAHPATPHSHSMPGTPHQQPQSSSVPTGGH 84
            |::.||:||..||  ||||
Mosquito     4 SSSHGPSASVSAV--STPI---------------------------------------------- 20

  Fly    85 LLQLQAPLPSAGGGTGAGAVTPSGLSMGASNQSLGVSVGAASSVSGISITPPNSAGLRQSTVFDF 149
                           .||....|..:.|:|:|               :.|||||.|.......:.
Mosquito    21 ---------------NAGTRPDSAPAFGSSHQ---------------ASTPPNSGGKFLDVKTEE 55

  Fly   150 KFKRRPSLKVLMTKLPSTDSLSNSPAPSSPGIANWASDNR---DGNVADKSAADAAKLNRKESYK 211
            |..||.||::|:.||||.||...||.||||||..| :||.   :....||:  |:||||||||||
Mosquito    56 KKNRRTSLQMLLPKLPSNDSAGPSPGPSSPGITGW-NDNSPKIESGFPDKN--DSAKLNRKESYK 117

  Fly   212 AQRKNYRREKKRVASELMNSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSS 276
            |||||||||||||||||:||||||||||||||||:|||||||||||||||||||.||||.|||||
Mosquito   118 AQRKNYRREKKRVASELLNSLQDPAVIVLADWLKIRGTLKSWTKLWCVLKPGLLFIYKSPKTKSS 182

  Fly   277 HWVGTVMLTSCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQ 341
            ||||||:||||||||||||||||||||||||:|:|||||||||||:|||||||||:|||||||||
Mosquito   183 HWVGTVLLTSCQVIERPSKKDGFCFKLFHPLDQTIWAPRGPDKETMGAVVQPLPTSYLIFRAPSQ 247

  Fly   342 AAGKCWMDALELSLRCSALLLRS------NSSTGTAPTSSYIGEPLPVSHETQWSEADYEKHFND 400
            ||||||||||||||||||||:||      |.|.|...|          :||||||||||||||::
Mosquito   248 AAGKCWMDALELSLRCSALLVRSVPNIDTNLSEGATST----------THETQWSEADYEKHFDE 302

  Fly   401 HD--------------------------------------------------------------- 402
            |.
Mosquito   303 HAPRLKEHLNYLLKYLPPSPPEKKNLRVEPIEKSLPRSACPSPTPIFQQLYLAVAHWERYLRDSP 367

  Fly   403 ----------------------------------------------------------------- 402
                                                                             
Mosquito   368 DFFRCRSVDVGGPLRRRMPSSSGTVSPAGADGDEEEDEEVFRCGGRDDGTMLMAGGRRRNSYQVG 432

  Fly   403 ---------------------------------------------LDADSQNEAPNAVMSGLESE 422
                                                         ||.|||.:....|.:| ||:
Mosquito   433 TVAETSDTGKLMAVNGSEKLRRRSSPADFSQGHHGITIRISDDQYLDIDSQLDQGTMVSAG-ESD 496

  Fly   423 SESDPAEPAQDDVVDQQCVETSYVPFTEEEFGEQGEQVEELAEENKSLIWCIVKQVRPGMDLSKV 487
            ||||..|..  ||  ::..||.||...|||||..|||||||.||:|||||.:|||||||||||||
Mosquito   497 SESDLGEGM--DV--EEFPETPYVHSPEEEFGAAGEQVEELPEEHKSLIWFLVKQVRPGMDLSKV 557

  Fly   488 VLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDDAFTRMKLVVQWYLSSFYKKPKGLKKPYNPIL 552
            ||||||||||||||||:|||||||:|||||.|||.|||||.|||||||.||||||||||||||||
Mosquito   558 VLPTFILEPRSFLDKLADSYYHADILSKAVLEDDPFTRMKTVVQWYLSGFYKKPKGLKKPYNPIL 622

  Fly   553 GERFRCYWQHPSGSRTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGA 617
            ||.|||||||.:||||||||||||||||||.||||||:|||.|:||||||||||||||||:|||.
Mosquito   623 GETFRCYWQHENGSRTFYIAEQVSHHPPVSVFYVTNRQDGFCISCSILAKSKFYGNSTSAILEGV 687

  Fly   618 ATMTLLPRGECYTATTPYAHCKGILMGTLSMELGGKINIECENTGYRTELEFKLKPFLGGADATN 682
            ||:|||||||.||...||||||||||||||||||||::||||||||:|||||||||||||.:.||
Mosquito   688 ATLTLLPRGESYTLAVPYAHCKGILMGTLSMELGGKVSIECENTGYKTELEFKLKPFLGGNEYTN 752

  Fly   683 VVVGKIKLGKETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQ 747
            :||||:||||||:||||||||.|.|:|||:|.||||||....:.|::||.|:.||::.|..|||:
Mosquito   753 LVVGKLKLGKETMATINGHWDSEIRIKDSRTNEETVLFNPTPDIRNRRLKRFTVPMESQGMNESE 817

  Fly   748 RLWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSY-GQWLYKYADLR 811
            ||||.||.||..:|||.||||||.|||.||..||||.::.:..:|.||:.|.. |||.||:||||
Mosquito   818 RLWQHVSAAIHRDDQVGATEEKTALEEAQRISAKERKATCTEWVPLLFQQDFVTGQWHYKFADLR 882

  Fly   812 PWDSRNDVRQYECQFKVLTQTRHKSVPIVHGAEMIHPLRSSIETLSRTQRQSPAGQPLPPGGSAV 876
            |||.|||:||||..:::.|:|||:: |:|..|.::     |.:.|:..|..|        .||.
Mosquito   883 PWDPRNDLRQYESNYRIQTKTRHQA-PMVRTASVV-----STDPLNILQVDS--------RGSL- 932

  Fly   877 PKAKNKSLVLAPR------------DTNSDSSQSPQGAVKRSSSSAIKQLALAVDQVNRVLEQHT 929
              .||:|.|:..|            |.|||||.|.......||:..::.|    |.:|:.||:|:
Mosquito   933 --RKNRSGVMKSRKISSNTSTPDLNDPNSDSSHSNDHDTVLSSTRIMQTL----DDINKKLEEHS 991

  Fly   930 RQLNEISQRLERMQYSPPPSSMSAHSLHMLGGGVSQSTV-IKSLIYALIGLAFSLILRW 987
            ::|.::...::::.::||    ....::..|.....|:: :|:|:..::||...|:|.|
Mosquito   992 KKLVKLQLDMDKIHWAPP----RRQQINADGPLAFLSSINVKTLVLIIVGLLVQLLLSW 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orp8	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	121/129 (94%)
		Oxysterol_BP	471..817	CDD:460126	266/346 (77%)
Orp8	XP_061497346.1	None