Protein Alignment Orp8 and osbpl8

DIOPT Version :10

• Sequence 1: NP_001189250.2
• Gene: Orp8 / 42412
• FlyBaseID: FBgn0261550
• Length: 990
• Species: Drosophila melanogaster
• Sequence 2: XP_073802961.1
• Gene: osbpl8 / 101883298
• ZFINID: ZDB-GENE-110309-1
• Length: 907
• Species: Danio rerio
• Alignment Length: 937
• Identity: 439/937 - (46%)
• Similarity: 576/937 - (61%)
• Gaps: 94/937 - (10%)

  Fly    90 APLPSAGGGTGAGAVTPSGLSMGASNQSLGVSVGAASSVSGISITPPNSAGLRQSTVFDFKFKRR 154
            |.:||    ..|..:||:  .|....:..|:.......::..|::|    |:..|..||     |
Zfish    29 ALMPS----DDAAFLTPA--KMSQKGKEAGLHTPNKDQLTSPSLSP----GISYSHGFD-----R 78

  Fly   155 PSLKVLMTKLPSTDSLSNSPAPSSPGIANWASDNRDGNVADKS-AADAAKLNRKESYKAQRKNYR 218
            ...::|..|..||.|:|.|           .|:.:..|.:||. :....||.:|||.|.|:||||
Zfish    79 GKEEILPLKEDSTHSISKS-----------KSETKLYNGSDKDVSVSGNKLTKKESLKVQKKNYR 132

  Fly   219 REKKRVASELMNSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSSHWVGTVM 283
            .||||...||::::.||:|||:|||||:|||||||||||||||||:|||||:  .|:..|||||:
Zfish   133 EEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKT--NKNGQWVGTVL 195

  Fly   284 LTSCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQAAGKCWM 348
            |.:|::||||||||||||||||||||||||.:||..|.:|::.||||:::|||||.|::.|:|||
Zfish   196 LNACELIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSHLIFRAASESDGRCWM 260

  Fly   349 DALELSLRCSALLLRSNSSTG------TAPTSSYIGEPLPVSHETQWSEADYEKHFNDHDLDAD- 406
            |||||:|:||:||.|:....|      ||..|......|..:|..|..:.:....|.|.||.:|
Zfish   261 DALELALKCSSLLKRTMIREGKEDPPQTAEHSHINFYSLLRAHNMQGFQFNDSDQFKDPDLYSDK 325

  Fly   407 -------SQNEAPNAVMSGLESESESDPAEPAQDDVVD----QQCVETSYVPFTEEEFGEQGE-- 458
                   .|.|..|.||...| ||:||.:|..:|..:|    :...||.|:..:.||.||.||
Zfish   326 SDRENEPEQEEWENEVMEKSE-ESDSDTSERQEDSYIDLDPNETLRETMYIEQSHEELGEAGEAS 389

  Fly   459 QVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDDAF 523
            |.|.::||||||||.::||||||||||||||||||||||||||||||.|||||.||:|..|::|:
Zfish   390 QTETVSEENKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSFLDKLSDYYYHADFLSEAAVEENAY 454

  Fly   524 TRMKLVVQWYLSSFYKKPKGLKKPYNPILGERFRCYWQHP-SGSRTFYIAEQVSHHPPVSAFYVT 587
            .|||.||:||:|.|||||||||||||||:||.:||.|.|. :.|:|||||||||||||||||||:
Zfish   455 NRMKKVVKWYISGFYKKPKGLKKPYNPIIGEMYRCLWIHSRTNSKTFYIAEQVSHHPPVSAFYVS 519

  Fly   588 NREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGECYTATTPYAHCKGILMGTLSMELGG 652
            ||:|||.::.||||||||||||.||:|:|.|.:|.|.|||.|....|||||||||.||:::||||
Zfish   520 NRKDGFCLSGSILAKSKFYGNSLSAILDGEARLTFLNRGEDYVMNMPYAHCKGILYGTMTLELGG 584

  Fly   653 KINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEET 717
            ::.|.||.|||..:||||||||||.:|:.|.:.||||||||.|||:.||||.|..:.|.||||..
Zfish   585 QVCIACEKTGYSAQLEFKLKPFLGSSDSVNQISGKIKLGKEVLATLEGHWDSEVFINDKKTGELE 649

  Fly   718 VLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKE 782
            ..:....|.|.:||||..||.:.|...||:||||.|:.||.|:||..||.||.:|||.||..|:|
Zfish   650 TFWNPTPELRQQRLTRCTVPPEEQAEFESERLWQHVTRAINNKDQTEATNEKFILEEAQRKAARE 714

  Fly   783 RLSSDSVHMPDLFELD-SYGQWLYKYADLRPWDSRNDVRQYECQFKVLTQTRHKSVPIVHGAEMI 846
            |.:......|.|||.| :.|:|.|:|||.||||..||:.|.|....:.|:.||:: |:|..|.::
Zfish   715 RKAKCEEWTPALFEQDPTTGEWHYRYADTRPWDPLNDLIQLEKDGCIQTKVRHRT-PMVRSASVV 778

  Fly   847 HPLRSSIETLSRTQRQSPAGQPLPPGGSAVPKAKNK--------SLVLAPRDTNSDSSQSPQGAV 903
                 |:.|....:|.:...|      ...||.|:|        |...:|.....|||.|.:...
Zfish   779 -----SLSTQQGPRRDNYLSQ------VTGPKRKHKTDKPKSPESGCSSPEPDRQDSSGSERHKS 832

  Fly   904 KRSS-----SSAIKQLALAVDQVNRVLEQHTRQLNEISQRLERMQYSPPPSSMSAHSLHMLGGGV 963
            |.||     .:.:.::..|::.:.:..|...|.::.:..|:     :...|:.|:...|
Zfish   833 KHSSRHRKKGTDLSEIQSAIESIRQTQEDINRSVSALRSRM-----ASQTSTESSFLTH------ 886

  Fly   964 SQSTVIKSLIYALIGLAFSLILRWLFK 990
            ....:|..||:      ..::|.::||
Zfish   887 RDIAIILFLIF------LQVLLNFIFK 907

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orp8	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	90/129 (70%)
		Oxysterol_BP	471..817	CDD:460126	221/347 (64%)
osbpl8	XP_073802961.1	None