Protein Alignment Orp8 and osbpl10

DIOPT Version :10

• Sequence 1: NP_001189250.2
• Gene: Orp8 / 42412
• FlyBaseID: FBgn0261550
• Length: 990
• Species: Drosophila melanogaster
• Sequence 2: XP_002941862.1
• Gene: osbpl10 / 100496082
• XenbaseID: XB-GENE-995970
• Length: 768
• Species: Xenopus tropicalis
• Alignment Length: 841
• Identity: 229/841 - (27%)
• Similarity: 355/841 - (42%)
• Gaps: 161/841 - (19%)

  Fly    42 SAKQQGAAGGGDTLAHPATPHSHSMPGTPHQQPQSSSVPTGGHLLQLQAPLPSAGGGTGAG---- 102
            :|:||.:.||....:..::..:.|...:|....:...|..|      ...|| ||.|:|:|
 Frog     4 AAQQQHSGGGSSNSSSRSSSRATSAGSSPSSAGRGLPVGCG------SGGLP-AGSGSGSGRALQ 61

  Fly   103 -----AVTPSGLSMGASNQSLG------VSVGAASSVSGISITPPN-------SAGLRQSTVFDF 149
                 |:....:..||:..|.|      |..|..|..:.:.....|       .:|:.|..|.:.
 Frog    62 QAQAVALAAGKVDGGAAQASKGGREHKQVIEGVLSKYTNLIQGWQNRYFILDFDSGILQYYVTEA 126

  Fly   150 KFKRRPSLKVLMTKLPSTDSLSNSPAPSSPGIANWASDNRDGNVADKSAADAAKLNRKESYKAQR 214
            ...::|...:.::  .|..|||.    .:|.:....|.|  |.:....||||   ..::.:..|.
 Frog   127 SKNQKPRGSLSLS--GSVISLSE----EAPNVIIVYSTN--GEMYKLRAADA---KERQFWMTQL 180

  Fly   215 K---NYRREKKRVASELMNSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQKTKSS 276
            :   .:..|.|...|:...|..          |...||..|.:.           ..:.|.|.|.
 Frog   181 QACAKFHSESKSAVSQRARSYS----------LLPHGTSNSPSP-----------ASQRQMTHSG 224

  Fly   277 HWVGTVMLTSCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFRAPSQ 341
            ..:.||.........|.||.....  ..|.:::.:....|..|..:.|:              ..
 Frog   225 PSIVTVTHHKSPAAARRSKNQNPA--QLHEVKEVMAQVEGQQKNLVHAI--------------ES 273

  Fly   342 AAGKCWMDALELSLRCSALLLRSNSSTGTAPTSSYIGEPLPVSHETQWSEADYEKHFND------ 400
            .:|...:.||:..|    |||::.|    |.|.|.:||.|.:..::.:......|:.:.
 Frog   274 LSGSGPLSALDQDL----LLLKATS----AATLSCLGECLHLLQQSVYQSGQNNKNISTDSILSW 330

  Fly   401 HDLDADSQNEAPNAVMSGLESESESD------PAEPAQDDVVDQQCVETSYVPFTEEEFGEQGEQ 459
            |...:.|.....|..:|.|.| |:::      |:.| ||..|.::..||. .|..|||..:..:.
 Frog   331 HGPKSHSTENLKNGHLSSLPS-SDTNLTWPIIPSMP-QDYKVLERDTETG-PPEAEEELTDTEDN 392

  Fly   460 VEE---LAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSFLDKLSDSYYHADLLSKAVQEDD 521
            .||   :.::.:|:|..::.|::.||||:||||||||||.||.|:..::...|.||.........
 Frog   393 EEEDLGVMDDQRSVILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYANFMAHPDLFLSIAAGAT 457

  Fly   522 AFTRMKLVVQWYLSSFYKKPKG--LKKPYNPILGERFRCYWQHP--------------------- 563
            ...|:...|::||::|::..||  .||||||:|||.|.|.|..|
 Frog   458 PEERIICFVEYYLTAFHEGRKGAVAKKPYNPVLGETFHCSWDVPKENVKSFRTQSASKETVPPPS 522

  Fly   564 -SGS--RTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPR 625
             ||.  :..::|||||||||||.||...:|....:...:..||||.|.|....:.|...:.|:..
 Frog   523 SSGEAYKLRFVAEQVSHHPPVSCFYCECKEKKMCVNAHVWTKSKFLGMSVGVSMVGEGILRLMEH 587

  Fly   626 GECYTATTPYAHCKGILMGTLS-MELGGKINIECENTGYRTELEFKLKPFLGGA----------D 679
            ||.|..|.|.|:.:.||  |:. :|||||:||.|..|||...:.|..|||.||.          :
 Frog   588 GEEYVFTLPSAYARSIL--TVPWVELGGKVNISCAKTGYVATVIFHTKPFYGGKVHRVTAEVKHN 650

  Fly   680 ATNVVVGKIKLGKETLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEAN 744
            .||.:|.|.:          |.|:.......| |||.    |:...|:...:.:.:.||:.|...
 Frog   651 PTNTMVCKAQ----------GEWNGTLEFTYS-TGET----KLIDTTKLLNIKKKIRPLEKQGQC 700

  Fly   745 ESQRLWQRVSEAIANEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSYGQWLY 805
            ||:|:|:.|:.|:.:.:..||:|:|..|||||||::::|.|.::...|..|..:..| |.|
 Frog   701 ESRRVWENVTNALKSGNIEAASEQKHQLEERQRAESRQRASLNTTWKPKYFIKEGEG-WAY 760

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orp8	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	21/129 (16%)
		Oxysterol_BP	471..817	CDD:460126	131/372 (35%)
osbpl10	XP_002941862.1	PH_ORP10_ORP11	91..197	CDD:270106	23/116 (20%)
		Oxysterol_BP	409..766	CDD:460126	130/370 (35%)