Protein Alignment Orp8 and osbpl8

DIOPT Version :10

• Sequence 1: NP_001189250.2
• Gene: Orp8 / 42412
• FlyBaseID: FBgn0261550
• Length: 990
• Species: Drosophila melanogaster
• Sequence 2: XP_012814032.1
• Gene: osbpl8 / 100145444
• XenbaseID: XB-GENE-5961068
• Length: 988
• Species: Xenopus tropicalis
• Alignment Length: 1044
• Identity: 456/1044 - (43%)
• Similarity: 593/1044 - (56%)
• Gaps: 161/1044 - (15%)

  Fly    28 SAPAVASSTPIRINSAKQQGAAGGGDTLA----------HPATPHSHSMPGTPHQQPQSSSVPTG 82
            |:..||:|....|..||.....|....|:          .|...|||:.    |.:    :|...
 Frog    25 SSHLVANSESPLILPAKMSQRQGKDAYLSPTKDLVQATLSPGIIHSHAF----HLR----TVTLN 81

  Fly    83 GHL-LQLQAPL---PSAGGGTGAGAVTPSGLSMGASNQSLGVSVGAASSVSGISITPPNSAGLRQ 143
            .|| ::.:.||   ..||...|.....|.|..: ..|.|.|          |.:...|...|
 Frog    82 KHLAMKEEGPLRRRSCAGVSPGTFLPRPDGRKL-VRNASFG----------GYNELSPALPG--- 132

  Fly   144 STVFDFKFKRRPSLKVLMTKLPSTDSLSNSPAPSSPGIANWASDNRDGNVADKSAADA-AKLNRK 207
               ||     :...:||.:|..::.|:|.|           .|:::..|.:::..|.| :||.:|
 Frog   133 ---FD-----KGKDEVLQSKEDTSISMSKS-----------KSESKLYNGSERDIASASSKLTKK 178

  Fly   208 ESYKAQRKNYRREKKRVASELMNSLQDPAVIVLADWLKVRGTLKSWTKLWCVLKPGLLLIYKSQK 272
            ||.|.|:||||.||||...||::::.||:|||:|||||:|||||||||||||||||:|||||:
 Frog   179 ESLKVQKKNYREEKKRATKELLSTITDPSVIVMADWLKIRGTLKSWTKLWCVLKPGVLLIYKT-- 241

  Fly   273 TKSSHWVGTVMLTSCQVIERPSKKDGFCFKLFHPLEQSIWAPRGPDKETIGAVVQPLPTAYLIFR 337
            .|:..|||||:|.:|::||||||||||||||||||||||||.:||..|.:|::.||||::|||.|
 Frog   242 PKNGQWVGTVLLNACEIIERPSKKDGFCFKLFHPLEQSIWAVKGPKGEAVGSITQPLPSSYLIIR 306

  Fly   338 APSQAAGKCWMDALELSLRCSALLLRSNSSTG------TAPTSSYIG-------EPLPVSHETQW 389
            |.|::.|:||||||||:|:||:||.|:....|      ::..:|::|       ..|..:...|.
 Frog   307 AASESDGRCWMDALELALKCSSLLKRTMIREGKEHDLNSSADNSHVGFYGLLRVNNLHSNENFQL 371

  Fly   390 SEADYEKHF--------------NDHDLDADSQNEAPNAVMSGLESESESDPAEPAQDDVVD--- 437
            ::::.|:|.              ||||.| :|.|:.     .|...||:||.:|...|..||
 Frog   372 NDSEIERHHFKDQDTYSDKSDKDNDHDHD-ESDNDG-----LGKSEESDSDTSERQDDSFVDPDP 430

  Fly   438 -QQCVETSYVPFTEEEFGEQGE--QVEELAEENKSLIWCIVKQVRPGMDLSKVVLPTFILEPRSF 499
             :...||:||....||.||.||  |.|.::||:|||||.::||||||||||||||||||||||||
 Frog   431 PELIKETTYVEEAHEELGEAGEASQTETVSEEHKSLIWTLLKQVRPGMDLSKVVLPTFILEPRSF 495

  Fly   500 LDKLSDSYYHADLLSKAVQEDDAFTRMKLVVQWYLSSFYKKPKGLKKPYNPILGERFRCYWQHP- 563
            ||||||.|||||.||:|..|::.::|||.||:||||.||||||||||||||||||.|||.|.||
 Frog   496 LDKLSDYYYHADFLSEAALEENPYSRMKKVVKWYLSGFYKKPKGLKKPYNPILGETFRCLWIHPR 560

  Fly   564 SGSRTFYIAEQVSHHPPVSAFYVTNREDGFSITCSILAKSKFYGNSTSAVLEGAATMTLLPRGEC 628
            :.|:||||:||||||||||||||:||:|||.::.||||||||||||.||:|||...:|.|.|||.
 Frog   561 TSSKTFYISEQVSHHPPVSAFYVSNRKDGFCLSGSILAKSKFYGNSLSALLEGEGRLTFLNRGED 625

  Fly   629 YTATTPYAHCKGILMGTLSMELGGKINIECENTGYRTELEFKLKPFLGGADATNVVVGKIKLGKE 693
            |..|.|||||||||.||:::||||.:.|.||.|.|...|:||||||||..|:.|.:.||||||||
 Frog   626 YLMTMPYAHCKGILYGTMTLELGGSVTITCEKTSYSATLDFKLKPFLGSDDSVNQISGKIKLGKE 690

  Fly   694 TLATINGHWDKECRVKDSKTGEETVLFKVDAETRSKRLTRYMVPLDLQEANESQRLWQRVSEAIA 758
            .|||:.||||.|..:.|.||......:....|.|..||.|..|..:.|...||:|||:.|:.||.
 Frog   691 VLATLEGHWDSEVFIHDKKTDVFETFWNPTLEIRHHRLIRCTVNQEEQGEFESERLWRLVTLAIN 755

  Fly   759 NEDQVAATEEKTVLEERQRADAKERLSSDSVHMPDLFELDSY-GQWLYKYADLRPWDSRNDVRQY 822
            |:||..||:||.||||.||..||||.:........|||.|.. |:|.|||||.||||..||:.|:
 Frog   756 NKDQTEATQEKFVLEEAQRKAAKERKAKGEEWTCKLFEQDPLTGEWHYKYADTRPWDPLNDLIQF 820

  Fly   823 ECQFKVLTQTRHKSVPIVHGAEMIHPLRSSIETLSR--TQRQSPAGQPLPPGGSAVPKAKNK--- 882
            |....:.|:.||:: |:|....:|:        ||.  .:|:..:.|      ..|||.|:|
 Frog   821 ENDGVIQTKVRHRT-PMVRSGSVIN--------LSNQGAKREKCSYQ------VCVPKLKHKASG 870

  Fly   883 ------SLVLAPRDTNSDSSQSPQGAVKRSSSSAIKQLA--------------------LAVDQV 921
                  |...:|...|.|||.|..||......:.:|.||                    .|:|.:
 Frog   871 QQKKGESGCSSPELDNQDSSGSEAGASDEEQMNVLKPLAHLLSHNNRVRKKGADHGELQSAIDSI 935

  Fly   922 NRVLEQHTRQLNEISQRLERMQYSPPPSSMSAHSLHMLGGGVSQSTVIKSLIYALIGLAFSLILR 986
            .:..|:..|.:..:..|:.....|...|.:......              :|:.||.|  .:.:.
 Frog   936 KKTQEEINRNIIALRNRVSVNTSSTENSFLQQRDYF--------------IIFFLITL--QIAVS 984

  Fly   987 WLFK 990
            :|||
 Frog   985 YLFK 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orp8	NP_001189250.2	PH_OPR5_ORP8	231..361	CDD:270103	90/129 (70%)
		Oxysterol_BP	471..817	CDD:460126	219/347 (63%)
osbpl8	XP_012814032.1	PH_OPR5_ORP8	202..331	CDD:270103	91/130 (70%)
		Oxysterol_BP	467..813	CDD:460126	218/345 (63%)